Comparative study of assay and dissolution of different manufacturer's levocetirizine dihydrochloride tablets by hplc
Abstract
Levocetirizine dihydrochloride is commonly used to treat allergic conditions, and its quality plays an important role in patient safety and effectiveness. In this study, a comparative evaluation was carried out on Levocetirizine dihydrochloride tablets from different manufacturers to assess their quality and performance. Four marketed tablet brands were selected and evaluated for physical parameters such as weight variation, hardness, friability, and disintegration according to Indian Pharmacopoeia guidelines. The drug content (assay) and dissolution behaviour of the tablets were analysed using High Performance Liquid Chromatography (HPLC). The results showed that all tablet formulations complied with pharmacopeial limits and exhibited acceptable drug content and release profiles. Although minor differences were observed among the brands, all formulations met the required quality standards. The study confirms that the selected marketed Levocetirizine dihydrochloride tablets are of good quality and suitable for therapeutic use.
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