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Levocetirizine: A Superior Option for Managing Allergic Syndromes in Comparative Perspective

Partha Pratim Das, Ananya Chanda, Shaibal Chandra, Trisha Chatterjee, Soma Das

2026

Abstract

Allergic conditions are commonly treated with a wide range of drugs; however, antihistamines remain one of the most effective and preferred therapeutic options, particularly for the management of allergic rhinitis. This review focuses on the superiority of antihistaminic agents in the treatment of allergic disorders, especially allergic rhinitis (AR), a chronic inflammatory disease affecting the nasal mucosa. AR is characterized by symptoms such as nasal congestion, sneezing, rhinorrhea, nasal itching, pruritus, redness, tearing and itching of the eyes. The prevalence of AR has increased significantly worldwide and continues to rise due to various environmental and lifestyle-related factors. Although AR is not a life-threatening disease, it considerably affects the quality of life and interferes with daily activities and productivity. In recent years, particularly after the COVID-19 pandemic, allergic reactions, breathing difficulties, and nasal irritation have become increasingly common. Environmental pollution, dietary habits, climatic changes, and exposure to allergens are major triggering factors contributing to the growing incidence of allergic disorders. Therefore, effective management of AR using safe and potent medications has become increasingly important. Understanding the pathogenesis of allergic rhinitis is essential before initiating appropriate treatment. Accordingly, this review discusses the introduction, pathogenesis, diagnosis, classification and…

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