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Effectiveness of a stepped‐care programme of WHO psychological interventions in a population of migrants: results from the RESPOND randomized controlled trial

M. Purgato, Federico Tedeschi, G. Turrini, C. Cadorin, Beatrice Compri, G. Muriago, G. Ostuzzi, I. Pinucci et al.

World Psychiatry, 2025

17 citations

Abstract

Migrant populations – including labour migrants, undocumented migrants, asylum seekers, refugees, internationally displaced persons, and other populations on the move – are exposed to a variety of stressors that affect their mental health. We designed and tested the effectiveness of a stepped‐care programme consisting of two scalable psychological interventions developed by the World Health Organization (WHO) and locally adapted for migrant populations. A parallel‐group randomized controlled trial was conducted in Italy. We recruited migrant adults (≥18 years) with psychological distress (score of at least 16 on the Kessler Psychological Distress Scale, K10). The experimental arm received psychological first aid (PFA) and a stepped‐care programme consisting of two WHO interventions adapted for this population group: first, Doing What Matters in Times of Stress (DWM) and, for participants who still reported significant levels of psychological distress after DWM, Problem Management Plus (PM+). Each intervention lasted 5‐6 weeks and was delivered remotely by lay facilitators. The control arm received PFA and care as usual (CAU). The primary outcome was the change in symptoms of depression and anxiety from baseline to week 21 after randomization, measured by the Patient Health Questionnaire Anxiety and Depression Scale (PHQ‐ADS). Between December 14, 2021 and April 18, 2023, 108 migrants were randomized to the stepped‐care intervention and 109 to CAU. Analysis of the primary…

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Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.

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