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Safety profile of semaglutide versus placebo in the SELECT study: a randomized controlled trial

Robert F. Kushner, D. Ryan, J. Deanfield, A. Kokkinos, Cintia Cercato, John P. H. Wilding, B. Burguera, Chau-Chung Wu et al.

Obesity, 2025

23 citations

Abstract

The objective of this study was to assess safety of once‐weekly subcutaneous semaglutide 2.4 mg versus placebo, beyond reduction in major adverse cardiovascular events, in patients with established cardiovascular disease and overweight or obesity.

How strong is the evidence?

Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.

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