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The effects of physical activity on mental health in adolescents with attention-deficit hyperactivity disorder: a randomized controlled trial

Chang Liu, Yi-Jian Yang, Stephen Heung-sang Wong, Andes Leung, C. Sit

International Journal of Behavioral Nutrition and Physical Activity, 2025

88 participants · 17 citations

Abstract

Adolescents with attention-deficit hyperactivity disorder (ADHD) represent a high-risk population with an elevated likelihood of developing mental health disorders. Physical activity (PA) has emerged as a promising intervention to enhance mental health in youth. However, no studies to date have comprehensively examined the immediate and sustained effects of PA, especially aerobic exercise-based PA, on mental ill-being—including internalizing problems (e.g., depression, anxiety, and stress) and externalizing problems (e.g., aggression)—as well as on two other critical indicators of mental health: psychological well-being (e.g., resilience) and cognitive function (e.g., inhibitory control) in adolescents with ADHD. Therefore, this study aimed to investigate whether an aerobic exercise-based PA intervention could elicit immediate and sustained benefits for mental health outcomes, including internalizing problems, externalizing problems, psychological well-being, and cognitive function, in adolescents with ADHD. This study was an assessor-masked, multicenter, randomized clinical trial. A total of 88 adolescents with ADHD were enrolled. Eligible participants were randomized in a 1:1 ratio to either the exercise group or the control group. Participants in the exercise group attended a 60-min session of aerobic exercise once a week for 12 weeks. Depression, anxiety, stress, aggression, and resilience were assessed using self-report questionnaires, and inhibitory control was…

How strong is the evidence?

Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 88 participants or records.

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