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Advancing iris melanoma brachytherapy: Eye plaque models for Monte Carlo simulations and 3D dosimetric datasets

Djedouani M, Viner A, Fletcher EM, Thomson RM

Medical physics, 2026

Abstract

Purpose: To develop and benchmark eye plaque models for Monte Carlo (MC) simulation of iris melanoma brachytherapy and to develop a database of 3D dose distributions for the iris plaques containing 103Pd${}^{103}{\rm Pd}$ , 125I${}^{125}{\rm I}$ , and 131Cs${}^{131}{\rm Cs}$ seeds.

Acquisition and validation methods: Five iris plaque models are developed with egs_brachy using published dimensions and material data; previously benchmarked seed models are used. Three plaque models are based on those used by the Mayo Clinic, consisting of a modification of the COMS 22 mm plaque design with a 10 mm void in the center surrounded by an inner collimating lip; plaques span 180∘$180^\circ$ , 270∘$270^\circ$ , and 360∘$360^\circ$ arcs. Two additional plaques are modeled: a modified Iris-270 plaque with no collimating lips; a partially-loaded COMS 22 mm plaque with no insert. Plaques are simulated in a water phantom with dose scored in (0.05 cm)3${\rm cm})^3$ voxels. Simulations under TG-43 conditions are also carried out. Doses are compared to previously published data for validation.

Data format and usage notes: The eye plaque models will be distributed with egs_brachy on GitHub (https://github.com/clrp-code/egs_brachy), along with an input file to facilitate custom simulations. The dosimetric database (https://doi.org/10.5281/zenodo.14776641) is comprised of 3D dose distributions for each plaque type, simulation condition, and radionuclides.

Potential applications: The iris plaque…

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