Role of Chondrocytes in the Development of Rheumatoid Arthritis Via Transmembrane Protein 147–Mediated NF‐κB Activation
Abstract
We have previously reported that the coactivation of NF‐κB and STAT3 in nonimmune cells, including synovial fibroblasts, enhances the expression of NF‐κB target genes and plays a role in chronic inflammation and rheumatoid arthritis (RA). This study was undertaken to examine the role of NF‐κB activation in chondrocytes and better understand the pathogenesis of RA. Furthermore, transmembrane protein 147 (TMEM147) was investigated as a representative NF‐κB activator in chondrocytes.
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