SAT-147 The Effect of Glucagon-Like Peptide-1 Receptor Agonists on Erectile Dysfunction and Testosterone Levels: A Systematic Review and Meta-Analysis
Abstract
Abstract Disclosure: A. Ezici: None. S. Ramadan: None. A. Bardak: None. Z. He: None. Background: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used for type 2 diabetes mellitus (T2DM) and obesity, but their impact on male reproductive health remains unclear. Previous studies have reported conflicting effects on erectile dysfunction (ED) and testosterone levels, ranging from potential improvements to no benefit or even adverse effects. Given the rising prevalence of T2DM, obesity, and sexual dysfunction, as well as the growing use of GLP-1RAs, we conducted this meta-analysis to evaluate their effects on ED and testosterone levels. Methods: We systematically searched PubMed, Embase, and Cochrane databases (up to January 19, 2025) for studies comparing GLP-1RA therapy to placebo or other antidiabetic agents in adults with T2DM and/or obesity. The measured outcomes were the International Index of Erectile Function-5 (IIEF-5) score and total testosterone levels, along with sex hormone-binding globulin (SHBG) levels, which help determine testosterone bioavailability. This study was registered in PROSPERO (CRD42025640594). We used a random-effects model to analyze all outcomes. Heterogeneity was assessed using the I² statistic. Review Manager 5.4 (Cochrane Foundation) was used for statistical analysis. Results: Of 1,319 screened studies, 71 underwent full-text review, and four met inclusion criteria. These included one randomized controlled trial, one prospective…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 396 participants or records.
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