Folate (methylenetetrahydrofolate reductase C677T and MTRR A66G) gene polymorphisms and risk of prostate cancer: A case–control study with an updated meta-analysis
Abstract
Methylenetetrahydrofolate reductase (MTHFR) and Methionine synthase reductase (MTRR) are the key enzymes of the folate pathway, which involved in DNA methylation. DNA methylation may affect the stability and integrity of DNA, that supposed to play a pivotal role in carcinogenesis. Hence, we aimed to investigate the association of
MTHFR
C677T and
MTRR
A66G gene polymorphisms with susceptibility to prostate cancer in North Indian population. We also performed meta-analyses of published literature on these polymorphisms to evaluate their association with prostate cancer.
We genotyped
MTHFR
C677T and
MTRR
A66G gene polymorphisms in 147 prostate cancer cases and 147 healthy controls using polymerase chain reaction-restriction fragment length polymorphism methods. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated for risk estimation. For meta-analysis, different databases were searched, and all statistical analyses were performed using Open Meta-Analyst software.
The present case–control study revealed that the T allele (OR = 1.67; 95% CI: 0.99–2.84,
P
= 0.05), CT genotype (OR = 1.92; 95% CI: 1.06–3.48,
P
= 0.02), dominant (TT + CT) model (OR = 1.85; 95% CI: 1.05–3.30,
P
= 0.03) of
MTHFR
C677T gene polymorphism, and G allele (OR = 1.92; 95% CI: 1.35–2.73,
P
= 0.0002) of
MTRR
A66G gene polymorphism were significantly associated with prostate cancer susceptibility. Meta-analyses of
MTHFR
C677T and
MTRR
A66G gene polymorphisms showed no significant association…
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Evidence Hub reads this as a meta-analysis. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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