Clinical Presentation, Grading, and Treatment Outcomes of Temporal Arteriovenous Malformations: A Systematic Review and Meta-Analysis
Abstract
Temporal arteriovenous malformations (AVMs) represent a specific subset of intracranial AVMs often linked to eloquent cortical regions and seizure risk. Their clinical features and treatment results are not fully understood, especially regarding location-specific factors. This systematic review and meta-analysis followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, involving a comprehensive search of PubMed and Scopus for studies on temporal AVMs with available clinical and outcome data. Only studies focusing on lesions within the temporal lobe were included. Data collected encompassed patient demographics, clinical presentation, Spetzler-Martin grades, treatment methods, and outcomes, with pooled estimates computed via a random-effects model. Seventeen studies with 319 patients were analyzed. The average age was 38.0 years, with sex distribution being relatively balanced, with males representing 147/319 patients (46.1%) and a pooled male proportion of 51.5%. The most common presentations were hemorrhage (147/319, 46.1%) and seizures (115/319, 36.1%). Low-grade lesions (Spetzler-Martin I-II) were most frequent, followed by intermediate and high-grade types. Surgical resection was the primary treatment approach. Favorable functional outcomes (modified Rankin Scale ≤ 2 or good Glasgow Outcome Scale) occurred in 235 patients (73.7%), while 65 (20.4%) had poor outcomes. Mortality was low, at 10 patients (3.1%). Visual deficits were…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 319 participants or records.
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