Initial Subjective Response to Nicotine Vaping Predicts Subsequent E-Cigarette Use in Early Adolescence: An ABCD Investigation
Abstract
Abstract Introduction Differences in sensitivity to substances are important for understanding variability in addiction propensity. The value of modeling subjective response to nicotine, particularly e-cigarettes, at first use as a predictor of future use remains largely untested. Methods This secondary analysis of the Adolescent Brain Cognitive Development (ABCD) Study data included 147 youth (51% female; mean age = 13 at first assessment) who reported vaping of an e-cigarette and provided their subjective response to that experience during the 4 years of baseline and annual follow-up data currently available. Analyses evaluated the longitudinal relationships between subjective response to vaping and subsequent annual e-cigarette episodes (ie, quantity) and use days (ie, frequency) using semi-parametric Bayesian mixture models. Effects were estimated at quantiles (25th, 50th, and 75th) of the e-cigarette use outcomes, representing lower, average (ie, median), and higher use. Results Greater pleasurable sensations to vaping at first use predicted greater past-year e-cigarette use for all participants, with youth endorsing higher use exhibiting stronger relationships (bLower use = 0.07–0.10; bMedian use = 0.37–0.75; bHigher use = 22.3–61.4). Greater initial unpleasant sensations to vaping also predicted greater subsequent use (bLower use = 0.16–0.19; bMedian use = 0.54–0.74). Among youth endorsing higher use, unpleasant subjective response was associated with future use…
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