Association of the dietary patterns with the risk of non-alcoholic fatty liver disease among Iranian population: a case-control study
Abstract
Background Diet-based recommendations can be developed for preventing and treating non-alcoholic fatty liver disease (NAFLD) after investigating the effects of whole diets on NAFLD. The aim of this study was to identify major dietary patterns and their association with the risk of NAFLD. Methods A total of 244 individuals (122 NAFLD patients and 122 controls) participated in this case-control study. The patients with NAFLD were diagnosed by a gastroenterologist. The participants’ dietary intake data were collected using a 147-item semi-quantitive food frequency questionnaire and major dietary patterns were identified by principal component analysis. Adherence to dietary patterns was divided into tertiles and its association with odds of NAFLD was investigated by multivariate logistic regression. Results The results showed four major dietary patterns, among which adherence to the “ordinary pattern” was positively associated with NAFLD risk. After adjusting for all confounding factors, individuals in the highest tertile of “ordinary pattern” exhibited a significantly elevated risk of NAFLD compared to the lowest tertile (OR = 3.74, 95%CI = 1.23–11.42, P trend< 0.001). As well as, Individuals in the second and third tertiles of the “traditional pattern” were associated with the risk of NAFLD compared to the lowest tertile (medium vs. lowest tertile OR = 2.37, 95%CI = 1.02–5.53; highest vs. lowest tertile OR = 3.58, 95% CI = 1.48–8.68, P trend< 0.001). The highest tertile of…
How strong is the evidence?
Evidence Hub reads this as a case-control, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 244 participants or records.
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