A-147 Using the Immature Granulocytes (IG) of White Blood Cells as a Reference for Sepsis Diagnosis
Abstract
Sepsis is a systemic inflammatory response syndrome (SIRS) caused by bacterial infection. It progresses rapidly and has a high mortality rate. Early and accurate diagnosis is crucial for reducing sepsis mortality. Common clinical diagnostic methods, such as blood culture or procalcitonin (PCT), have limitations in terms of time and sensitivity, posing significant challenges for clinical diagnosis and treatment. Immature Granulocytes (IG) include early immature cells of neutrophils, such as promyelocytes, metamyelocytes, and myelocytes, which increase significantly during acute inflammatory responses like infection or sepsis. Using the Sysmex XN series hematology analyzer, IG% (relative white blood cell percentage) and IG# (absolute count) can be quickly and automatically quantified, providing a potential tool for early sepsis diagnosis. This study not only investigates the correlation between IG and sepsis but also defines reference ranges for IG% and IG# in the Taiwanese population, providing a basis for sepsis diagnosis and application.
1.Equipment: Sysmex XN series hematology analyzer.
2.Sample Source: Blood samples from 420 emergency patients suspected of sepsis and 317 health patients.
3.Sample Preparation: Purple-top tubes containing K2EDTA anticoagulant.
4.Sepsis Determination Standard: Positive blood culture.
5.Analysis Methods: Microsoft Excel and SPSS software.
The biological reference range for healthy individuals was established using samples from health…
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