END Organ Disease in the Context of Human Herpes VIRUS 6 Viremia in Pediatric Allogeneic Hematopoietic STEM CELL Transplant Patients: A Case Series
Abstract
s / Biol Blood Marrow Transplant 20 (2014) S211eS256 S255 hours later. Because avoidance of stem cell exposure to CY occurs only in the 2 step approach, we compared engraftment rates and IR between the 2 groups. All 92 patients had good risk disease. In the 1 step vs the 2 step study, median time to ANC > 500/ul was 19(range 15-28 days) vs 11[range 9-16 days (p1⁄40.000-Mann-Whitney)], and for platelets > 20,000/ul, 29(range 18-52 days) vs 17(range 12-173 days) respectively (ns). The significant difference in time to ANC recovery in the 1 step group was possibly from the exposure of the donor PBSC’s to CY. When we accounted for the later occurrence of day 0 in the 2 step group, the median time to ANC recovery was still 3 days longer in the 1 step group even though this group received a higher median CD 34 dose. Possibly due to the earlier count recovery in the 2-step group, the median CD3/4 count at day 28 was 20(range 5-50/ul) in the 1 step group vs 54(range 11-299/ul) in the 2 step group. By day 90, differences between the groups resolved, with a median CD3/4 count of 157(range 29-397/ul) vs 147(range 10-814/ul) in the 1 and 2 step groups respectively. Median CD3/8 count at day 28 was 40 (range 3-157/ul) vs 57 (range 4-2682/ul) and at day 90 was 239(range 12-1439/ul) vs 204(range 2-2379/ul) in the 1 and 2 step groups respectively. The percentages of patients on steroids for GVHD at day 28 (13% in the 1 step group vs 31%) and 90 (18% vs 33%) was not significantly different…
How strong is the evidence?
Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health. Reported size: 92 participants or records.
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