Evolving management strategies in head and neck paragangliomas: A single‐centre experience with 147 patients over a 60‐year period
Abstract
•Paragangliomas of the head and neck (HNPGLs) are rare, slow-growing and usually benign tumours that arise in the paraganglion tissue associated with the autonomic nervous system. •Management strategies and outcome of 147 patients with a total of 289 HNPGLs in a 60-year period were evaluated. •In HNPGLs patients, the clinician should be aware of variable clinical manifestations, such as the risk of multifocality, associated sympathetic PGL, concurrent pheochromocytoma, catecholamine excess and risk of metastatic disease. •A decreasing number of HNPGLs were surgically resected. Increasingly, an active surveillance strategy has become the treatment of choice. •The genetic predisposition, a key factor in the clinical risk profile (phenotype) of HNPGL patient subgroups, in combination with a better understanding of the natural course of HNPGLs, has resulted in a more conservative management of HNPGL patients. This article is protected by copyright. All rights reserved.
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