Iron deficiency without anaemia in patients with inflammatory bowel disease
Abstract
The significance of iron deficiency without anaemia (IDWA) in patients with inflammatory bowel disease (IBD) is uncertain. In healthy populations IDWA is associated with fatigue. Screening for IDWA in IBD in clinical practice may be reduced given this lack of certainty, so IDWA may be undiagnosed. This thesis aims to understand the current testing and treatment of iron deficiency in IBD, in addition to the number of patients affected. To determine the importance of detecting and treating iron deficiency, the association of iron deficiency and fatigue in patients with IBD was investigated. This thesis comprised of three studies. In the first study, pathology results for iron status and prescription records from patients with IBD under the care of University Hospitals Southampton (UHS) were analysed for the monitoring, detection and treatment of iron deficiency in IBD. A systematic review was undertaken regarding the association of iron deficiency with fatigue in patients with IBD. The third study assessed multiple biochemical measurements of iron status in comparison to patient-reported outcome measures (PROMs) for fatigue, along with grip strength in patients with Crohn’s disease in remission. These were analysed with other variables for determinants of iron status and fatigue as part of the INTICO2 study. Blood tests from patients with IBD at UHS showed that many patients are not screened for iron deficiency, including those who are anaemic. The detected prevalence of iron…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
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