Perioperative Vitamin D Insufficiency Impacts Postoperative Outcomes in Abdominally Based Breast Reconstruction
Abstract
BACKGROUND
Hypovitaminosis D has been associated with wound healing complications in animal models as well as increased morbidity, infection, and hospital length of stay in clinical studies of surgical patients. This study aims to evaluate the association between perioperative Vitamin D (25-OHD) levels and postoperative outcomes in patients undergoing autologous breast reconstruction.
METHODS
We performed a retrospective review of patients undergoing autologous breast reconstruction at an academic institution. Patients with 25-OHD levels measured within three months of reconstruction were included. Variables of interest included patient demographics, comorbidities, perioperative 25-OHD levels, and postoperative surgical and medical complications. Standard statistical analysis was performed with significance set to p<0.05.
RESULTS
147 patients who underwent abdominally based breast reconstruction had undergone 25-OHD testing within three months of reconstruction and were included in analysis. 25-OHD insufficiency (<30 ng/mL) was found to be significantly associated with surgical site infections (OR 2.8, p=0.04), donor site seromas (OR 13.2, p=0.01), and medical complications (OR 4.0, p=0.02) on univariate and multivariable analysis.
CONCLUSION
Our data suggests that 25-OHD insufficiency impacts surgical and medical complications in patients undergoing autologous breast reconstruction. Enhanced understanding of perioperative 25-OHD status may help inform clinical decisions and…
Read the paper
Related studies
- Global, regional, and national burden of hepatitis B, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
- A meta‐analysis of anal cancer incidence by risk group: Toward a unified anal cancer risk scale
- Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021
- Exercise interventions in Alzheimer's disease: A systematic review and meta-analysis of randomized controlled trials
- Prognostic Significance of Carbonic Anhydrase IX Expression in Cancer Patients: A Meta-Analysis
- Glucocorticoid Resistance: Is It a Requisite for Increased Cytokine Production in Depression? A Systematic Review and Meta-Analysis
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.