147. Effect of fentanyl on glutamate release from nucleus accumbens to a rat model of postoperative pain
Abstract
Background & Aims: Injection of formalin into the hind paw of the rat induces a nociceptive behavioural response, which is considered to be an animal model of postoperative pain in humans. The aim of the present study is to evaluate the glutamate release from nucleus accumbens, as it is critically involved in the development of tolerance to opioids, with continuous fentanyl i.v. infusion after strong nociceptive stimulation with formalin injection.
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