A Nebulizer System For Positron Emission Tomography Imaging of Aerosols and Nanoparticles for Use in Preclinical Pulmonary Drug Delivery Studies
Abstract
This research project proposes to develop, integrate and characterize a nebulizer system for the nasal pulmonary delivery of radiopharmaceuticals in the form of aerosols containing nanoparticles for dynamic imaging studies using positron emission tomography (PET) in small animal models of disease. PET imaging of inhaled radiolabeled drugs in the form of aerosols containing nanoparticles can provide an in vivo measurement of drug distribution using the drug itself as the tracer. The system will be composed of 1) a nebulizer generator, 2) an anesthesia system, 3) a gas exhaust system, 4) a physiological monitoring system for respiratory synchronization and nebulizer triggering, and 5) a cylindrical bed to house in isolation the rodent. The proposed nebulizer system will be integrated into the Albira Si micro-PET/SPECT/CT imaging unit and it will help carry out translational imaging studies of novel PET radiolabeled drugs in small animal models of lung disease, such as lung cancer. The nebulizer system will be integrated and characterized for activity median aerodynamic diameter (AMAD) particle size distribution, aerosol mass distribution, nebulizer triggering using the respiratory cycle, drug and activity pulmonary distribution, and inhalation fraction and particle distribution in a normal and diseased rodent’s lung model.
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