Cytogenetic aspects of neutron -induced cellular response
Abstract
The RBE values for neutrons vary to a wide range and the influencing factors have been discussed. The relevance of cytogenetic end points as signature of the past neutron exposure, and the importance of cosmic component of neutron have been explored. The neutron-induced multiple damage sites are understood as more mutagenic, carcinogenic and lead to complex chromosome aberrations. Low energy neutrons (0.2- 2 MeV) are the principal concern in biodosimetry. They exhibit little or no β component and also independent of dose-rate effect. The review also emphasizes the wide range of RBE need to be considered for neutrons. Such knowledge may be helpful to draw guidelines to set dose limit for radiation workers under specific field and to devise effective neutron therapy. Also to make high-altitude travels and space voyages safer for human beings. Key words: Neutrons, RBE, adaptive response, dsb, radiation, chromosomal aberrations
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