147 Cutaneous Manifestations on Covid-19 Patients: A Systematic Review
Abstract
University Therapeutic drug monitoring (TDM) of biologics - encompassing the measurement of (trough) concentrations and anti-drug antibodies - is emerging as a valuable tool for clinical decision-making. While this strategy needs further validation, attention for its implementation into the clinic is warranted. Rapid testing and easy sampling are key to its implementation. Here, we aimed to evaluate the feasibility and volunteers’ perception of home microsampling for quantification of adalimumab (ADM) concentrations in psoriasis patients. In addition, we compared lateral flow testing (LFT) with enzyme-linked immunosorbent assay (ELISA). Pa- tients participating in the SUPRA-A study (clinicaltrials. gov NCT04028713) were asked to participate in a substudy where volumetric absorptive microsampling (VAMS) was performed at home. At 3 time points, whole blood and corresponding serum samples were collected for ADM measurement using an in-house ELISA. In addition, the patients’ perspective on microsampling was evaluated via a questionnaire. LFT-obtained ADM concentrations agreed very well with ELISA results (Pearson’s correlation ¼ 0.95 and R 2 ¼ 0.89). ADM concen-trationsdeterminedinbothcapillary(viafingerprick)andcorrespondingvenousbloodVAMSsamplescorrelatedstronglywithserumconcentrations(Pearson’scorrelation ¼ 0.87). Our preliminary data (n ¼ 7) on rapid testing and home-based microsampling are considered promising with regard to TDM implementation for adalimumab, warranting…
How strong is the evidence?
Evidence Hub reads this as a systematic review, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 42 participants or records.
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