P2‐147: polygenic composite scores in alzheimer's disease: a systematic review
Abstract
hypothesis-driven search for protective variants in APOE4+ (n1⁄46) and causal variants in APOE4(n1⁄48) groups. Four SNPs displayed significant associations with CSF-Tau/Aß ratios, of which three in the APOE4+ groups were concordant with the hypothesis (Fig.3-5): rs13133064, near GUF1 and GNPDA2, rs675080, on an intron of NTM, and rs9598666, near NFYAP1 and LINC00355. These SNPs did not affect brain cis gene expression. Conclusions: Stratification of subjects into ethnic groups, at the sub-European ancestral level, may help elucidate the APOE4-specific genetic architecture in LOAD. Replication in another large LOAD dataset and additional functional validation is required to confirm the putative protective loci identified here.
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