LB1053 Dysregulation of antioxidant enzyme PRDX5 in alopecia areata
Abstract
LB1052 Characterization of the B cell infiltrate in discoid lupus 1 2 3 4 5 4,5 MB Rapp , N Babkowski , F Esaa , T Curran , JH Anolik and CT Richardson 1 University of Buffalo, Buffalo, New York, United States, 2 University of Rochester, Rochester, New York, United States, 3 School of Medicine and Dentistry, University of Rochester, Rochester, New York, United States, 4 Dermatology, University of Rochester, Rochester, New York, United States and 5 Allergy, Immunology, and Rheumatology, University of Rochester, Rochester, New York, United States Discoid lupus erythematosus (DLE) is a severely disfiguring and difficult to treat autoimmune skin disease for which no new therapies have been FDA-approved in over 60 years. One potential therapeutic target is cutaneous B cells. Though rare in healthy skin, B cells are prevalent in DLE lesions, comprising 10-20% of the robust lymphocytic infiltrate. However, the phenotype and function of this expanded B cell population have not been evaluated in detail and it is unknown whether cutaneous B cells play a role in DLE pathogenesis. We analyzed T cells (CD3), B cells (CD20), and plasma cells (CD138) by immunohistochemistry in skin biopsies from seventeen patients with a clinical and pathologic diagnosis of discoid lupus. Consistent with known literature, T cells predominated the infiltrate (180.3 cells/hpf, range 88-299). However, the number of B cells was not insignificant and comprised an average of 21% of the total lymphocytic…
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