Browse studies, page 1221

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• Investigating Metformin for Cancer Prevention and Treatment: The End of the Beginning Cancer Discovery, 2012
• The Anti-diabetic Drugs Rosiglitazone and Metformin Stimulate AMP-activated Protein Kinase through Distinct Signaling Pathways Journal of Biological Chemistry, 2002
• Metformin kinetics in healthy subjects and in patients with diabetes mellitus British Journal of Clinical Pharmacology, 1981
• Metformin inhibits the senescence‐associated secretory phenotype by interfering with IKK / NF ‐κ B activation Aging Cell, 2013
• Metformin in cancer: translational challenges Journal of Molecular Endocrinology, 2012
• Molecular mechanism of action of metformin: old or new insights? Diabetologia, 2013
• Metformin: an old but still the best treatment for type 2 diabetes Diabetology & Metabolic Syndrome, 2013
• Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes: A Systematic Review and Meta-analysis Annals of Internal Medicine, 2016
• Thiazolidinediones, Like Metformin, Inhibit Respiratory Complex I Diabetes, 2004
• Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects With Type 2 Diabetes Diabetes, 2002
• Effects of Exenatide (Exendin-4) on Glycemic Control Over 30 Weeks in Patients With Type 2 Diabetes Treated With Metformin and a Sulfonylurea Diabetes Care, 2005
• Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin Nature Medicine, 2013
• Metformin: new understandings, new uses Drugs, 2003
• Metformin: clinical use in type 2 diabetes Diabetologia, 2017
• Metformin in patients with type 2 diabetes and kidney disease: a systematic review JAMA, 2014
• Metformin action: concentrations matter Cell Metabolism, 2015
• Efficacy of metformin in type II diabetes: results of a double-blind, placebo-controlled, dose-response trial The American Journal of Medicine, 1997
• Metformin as adjunct antituberculosis therapy Science Translational Medicine, 2014
• The Effect of Metformin and Intensive Lifestyle Intervention on the Metabolic Syndrome: The Diabetes Prevention Program Randomized Trial Annals of Internal Medicine, 2005
• Prevention of Diabetes in Women with a History of Gestational Diabetes: Effects of Metformin and Lifestyle Interventions The Journal of Clinical Endocrinology & Metabolism, 2008
• Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus Cochrane Database of Systematic Reviews, 2010
• Effects of Metformin on Spontaneous and Clomiphene-Induced Ovulation in the Polycystic Ovary Syndrome New England Journal of Medicine, 1998
• Efficacy and Safety of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin Added to Ongoing Metformin Therapy in Patients With Type 2 Diabetes Inadequately Controlled With Metformin Alone Diabetes Care, 2006
• Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth Cancer Research, 2007
• Metformin in Cancer Treatment and Prevention Annual Review of Medicine, 2014
• Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria Biochemical Journal, 2014
• Efficacy and Metabolic Effects of Metformin and Troglitazone in Type II Diabetes Mellitus New England Journal of Medicine, 1998
• Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission Cancer Research, 2009
• Metformin Inhibits Mammalian Target of Rapamycin–Dependent Translation Initiation in Breast Cancer Cells Cancer Research, 2007
• Metformin and Pathologic Complete Responses to Neoadjuvant Chemotherapy in Diabetic Patients With Breast Cancer Journal of Clinical Oncology, 2009
• Metformin. A review of its pharmacological properties and therapeutic use in non-insulin-dependent diabetes mellitus Drugs, 1995
• Efficacy and Safety Comparison of Liraglutide, Glimepiride, and Placebo, All in Combination With Metformin, in Type 2 Diabetes Diabetes Care, 2008
• Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes Diabetes Care, 2005
• Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis Cancer Prevention Research, 2010
• Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status Circulation Research, 2016
• Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state Journal of Clinical Investigation, 2010
• Metformin and the risk of cancer: time-related biases in observational studies Diabetes Care, 2012
• Metformin in polycystic ovary syndrome: systematic review and meta-analysis BMJ, 2003
• Effect of Vitamin E or Metformin for Treatment of Nonalcoholic Fatty Liver Disease in Children and Adolescents JAMA, 2011
• Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action Journal of Clinical Investigation, 2007
• Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism Cell, 2013
• Metformin: An Old Drug for the Treatment of Diabetes but a New Drug for the Protection of the Endothelium Medical Principles and Practice, 2015
• Mechanism by which metformin reduces glucose production in type 2 diabetes Diabetes, 2000
• Clinical pharmacokinetics of metformin Clinical Pharmacokinetics, 1996
• Metformin Is an AMP Kinase–Dependent Growth Inhibitor for Breast Cancer Cells Cancer Research, 2006
• Metabolic Effects of Metformin in Non-Insulin-Dependent Diabetes Mellitus New England Journal of Medicine, 1995
• Loss of metabolic plasticity underlies metformin toxicity in aged Caenorhabditis elegans eLife, 2014
• New Users of Metformin Are at Low Risk of Incident Cancer Diabetes Care, 2009
• Clomiphene, Metformin, or Both for Infertility in the Polycystic Ovary Syndrome New England Journal of Medicine, 2007
• Efficacy of Metformin in Patients with Non-Insulin-Dependent Diabetes Mellitus New England Journal of Medicine, 1995
• Metformin versus insulin for the treatment of gestational diabetes New England Journal of Medicine, 2008
• Metformin--mode of action and clinical implications for diabetes and cancer Nature Reviews Endocrinology, 2014
• Metformin: an update Annals of Internal Medicine, 2002
• Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group PubMed, 1998
• Clinical pharmacokinetics of metformin Clinical Pharmacokinetics, 2011
• ELMI - Prospective, Randomized, Controlled, Parallel-arm Study to Assess the Effects of the Combined Therapy of Empagliflozin and Linagliptin Compared to Metformin and Insulin Glargine on Renal and Vascular Changes in Type 2 Diabetes ClinicalTrials.gov · COMPLETED, 2019
• Comparison of Efficacy and Safety of Biphasic Insulin Aspart 30 Plus Metformin With Insulin Glargine Plus Glimepiride in Type 2 Diabetes ClinicalTrials.gov · COMPLETED, 2005
• A Phase III, Multicenter, Double-Blind, Randomized Study to Evaluate the Safety and Efficacy of the Addition of MK-3102 Compared With the Addition of Glimepiride in Subjects With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin ClinicalTrials.gov · COMPLETED, 2015
• COOrdinating CaRDIology CliNics RAndomized Trial of Interventions to Improve OutcomEs (COORDINATE) - Diabetes ClinicalTrials.gov · COMPLETED, 2022
• A Drug-drug Interaction Study Between the Novel Anti-hepatitis c Virus (HCV) Agent Daclatasvir and The Antidiabetic Agent Metformin in Healthy Volunteers ClinicalTrials.gov · COMPLETED, 2016
• Evaluation of the Role of Pyridoxine Adjuvant Therapy on the Blood Glucose Level in Type 2 Diabetic Patients ClinicalTrials.gov · COMPLETED, 2023
• A Prospective, Randomized, Double-blind, Multi-centre Study, Where the Possible Effect of Metformin to Prevent Late Miscarriage and Preterm Delivery is Studied in Women With Polycystic Ovary Syndrome (PCOS) ClinicalTrials.gov · COMPLETED, 2017
• Long Term Comparative Effectiveness of Once Weekly Semaglutide Versus Standard of Care in a Real World Adult US Population With Type 2 Diabetes - a Randomized Pragmatic Clinical Trial ClinicalTrials.gov · COMPLETED, 2023
• Continuous Glucose Monitoring System (CGMS) in Type 2 Diabetic Patients Inadequately Controlled by Metformine Monotherapy; Analyze of Glycemic Profile Before and After Association of Glimepiride ClinicalTrials.gov · COMPLETED, 2003
• A 26-week, Randomised, Open-labelled, Two-arm, Parallel-group, Treat-to-target Trial Comparing Efficacy and Safety of Soluble Insulin Analogue Combination (SIAC) Twice Daily (BID) With Biphasic Insulin Aspart (BIAsp) 30 BID, With or Without Metformin, With or Without DPP-4 Inhibitor, With or Without Pioglitazone in Subjects With Type 2 Diabetes in Inadequate Glycaemic Control on Once or Twice Daily Premixed or Self-mixed Insulin Regimen With or Without OADs (BOOST™: Intensify Premix 1) ClinicalTrials.gov · COMPLETED, 2010
• A Randomized, Open-Label, Two-Period, Crossover Study to Evaluate the Effect of CIN-107 on the Pharmacokinetics of the MATE Substrate, Metformin, in Healthy Subjects ClinicalTrials.gov · COMPLETED, 2020
• Efficacy and Long-Term Safety of Vildagliptin as Add-on Therapy to Metformin in Patients With Type 2 Diabetes ClinicalTrials.gov · COMPLETED, 2011
• A Phase 1, Open-Label, Two-Cohort Study to Assess the Effect of a Strong CYP3A4 Inducer on the Pharmacokinetics of Atumelnant and the Effect of Atumelnant on the Pharmacokinetics of CYP3A4, P-gp, and MATE1/2-K Substrates in Healthy Participants ClinicalTrials.gov · COMPLETED, 2026
• The Role of Adding Metformin in Insulin-Resistant Diabetic Pregnant Women - a Randomized Controlled Trial ClinicalTrials.gov · COMPLETED, 2013
• A Phase 3, Randomized, Double-blind, Placebo Controlled, Multicenter Trial to Evaluate the Safety and Efficacy of BMS-298585 in Combination With Metformin Therapy in Subjects With Type 2 Diabetes Who Have Inadequate Glycemic Control on Metformin Therapy Alone ClinicalTrials.gov · COMPLETED, 2004
• Open, Comparative, Randomized, Crossover, Single Dose Bioequivalence Study of Metformin 1000 mg Prolonged Release Tablets (JSC Farmak, Ukraine) vs Glucophage® XR 1000 mg Prolonged Release Tablets in Healthy Subjects Under Fed Conditions ClinicalTrials.gov · COMPLETED, 2019
• A Multicenter, Double-Blind, Randomized, Parallel-Group Study to Compare the Effect of 12 Weeks Treatment With LAF237 50 mg Bid to Placebo as Add-On Therapy in Patients With Type 2 Diabetes Inadequately Controlled With Metformin Monotherapy ClinicalTrials.gov · COMPLETED, 2013
• A Randomized, Double-blind, Double-dummy, 2-arm Parallel-group, Multicenter 24-week Study Comparing the Efficacy and Safety of AVE0010 to Sitagliptin as add-on to Metformin in Obese Type 2 Diabetic Patients Younger Than 50 and Not Adequately Controlled With Metformin ClinicalTrials.gov · COMPLETED, 2011
• A Phase 1 Clinical Trial to Compare and Evaluate the Safety and Pharmacokinetic Characteristics After Administration of Fixed-dose Combination of DW6014 and Loose Combination of Each Component in Healthy Adult Volunteers in Fasted Condition ClinicalTrials.gov · COMPLETED, 2023
• A Multicenter, Open-label Sub-study to LMF237A2302 to Assess the Effect of 24 Weeks Treatment With Initial Combination of Vildagliptin 100mg qd Plus Metformin 1000mg Bid in Drug Naive Patients With Type 2 Diabetes With Very Poor Glycemic Control ClinicalTrials.gov · COMPLETED, 2008
• Bioequivalence Study of the Fixed Dose Combination of 2.5 mg Saxagliptin and 500 mg Metformin Immediate Release (IR) Tablet Relative to 2.5 mg Saxagliptin Tablet and 500 mg Metformin IR Tablet Co-administered to Healthy Subjects in a Fasted and in a Fed State ClinicalTrials.gov · COMPLETED, 2009
• A 32-week Randomised, Multinational, Treat-to-target, Open Label, Parallel Group Comparison of Stepwise Insulin Intensification of Biphasic Insulin Aspart (BIAsp) 30 and Basal-bolus Therapy With Insulin Glargine and Insulin Aspart in Insulin naïve Type 2 Diabetic Patients Inadequately Controlled on Oral Anti-diabetic Therapy ClinicalTrials.gov · COMPLETED, 2016
• Insulin Glargine [rDNA Origin] Injection vs Pioglitazone as add-on Therapy in Patients Failing Monotherapy With Sulfonylurea or Metformin: a Randomized, Open, Parallel Study ClinicalTrials.gov · COMPLETED, 2005
• The Effect of Metformin on Clinical Course of Ischemic Etiology Chronic Heart Failure in Patients With Prediabetes: the Open-label Randomized Clinical Trial ClinicalTrials.gov · COMPLETED, 2019
• A Randomized, Double-Blind Trial Comparing the Effect of the Addition of Dulaglutide 1.5 mg Versus the Addition of Placebo to Titrated Basal Insulin on Glycemic Control in Chinese Patients With Type 2 Diabetes ClinicalTrials.gov · COMPLETED, 2022
• The Effect of DPP4 Inhibitor on Glycemic Variability in Patients With Type 2 Diabetes Treated With Twice Daily Premixed Human Insulin ClinicalTrials.gov · COMPLETED, 2019
• Effects of Metformin on Mood and Cognition During Nicotine Withdrawal ClinicalTrials.gov · COMPLETED, 2020
• A Single-Dose, Open-Label, Randomized, 4-Way Crossover Pivotal Study to Assess the Bioequivalence of the Metformin Component of the Fixed Dose Combination Tablet of Canagliflozin and Metformin Extended Release (XR) 1 x (50 mg/1000 mg) With Respect to the Metformin XR Tablet (Locally Sourced From Canada [GLUMETZA, 2 x 500 mg]) Coadministered With Canagliflozin (1 x 50 mg) in Healthy Fed and Fasted Subjects ClinicalTrials.gov · COMPLETED, 2016
• A Phase 1, Open-Label, Sequential Design Study to Evaluate the Potential Effect of Multiple Oral Doses of Extended-Release Combination of Naltrexone and Bupropion on the Pharmacokinetics of a Single Oral Dose of Metformin in Healthy Subjects ClinicalTrials.gov · COMPLETED, 2016
• Medical Optimization of Management of Type 2 Diabetes Complicating Pregnancy ClinicalTrials.gov · TERMINATED, 2022
• A Randomized, Open-label, Single-dose, 2-Way Cross-over Study to Compare the Safety and the Pharmacokinetic Characteristics of the Co-administration of Rosuvastatin and Metformin SR and YH14755 and to Investigate the Effect of Food on the Pharmacokinetics of YH14755 ClinicalTrials.gov · COMPLETED, 2014
• Inkretineffekten Hos Patienter Med Polycystisk Ovariesyndrom før og Efter Behandling af Insulinresistens (Incretin Effect in Patients With Polycystic Ovary Syndrome Before and After Treatment of Insulin Resistance) ClinicalTrials.gov · COMPLETED, 2017
• Effect of Treatment With Insulin Sensitizer on Arterial Properties, Metabolic Parameters and Liver Function in Patients With Nonalcoholic Fatty Liver Disease ClinicalTrials.gov · COMPLETED
• An Open-label, Randomized Two-Part, Two-Period Crossover Study to Demonstrate the Definitive Bioequivalence After Administration of Final Market Image (FMI) Sitagliptin /Metformin 50/500 mg and 50/1000 mg Fixed Dose Combination (FDC) and Concomitant Administration of 50 mg Doses of Sitagliptin and 500 or 1000 mg Doses of Metformin as Individual Tablets ClinicalTrials.gov · COMPLETED, 2006
• A Randomized, Parallel Group, Open-Label, Active-Controlled Study Comparing Acarbose With Voglibose in Patients Who Are Inadequately Controlled With Insulin Glargine Alone or in Combination With Metformin Based on Glycemic Control ClinicalTrials.gov · COMPLETED, 2012
• Implementation and Evaluation of a Diabetes Prevention Clinical Pathway in Primary Care ClinicalTrials.gov · COMPLETED, 2023
• A Double Blind, Placebo-controlled, Dose-ranging Study to Investigate the Effect on Glycemic Control, Safety, Pharmacokinetics and Pharmacodynamics of GLP-1 in Patients With Type 2 Diabetes Mellitus Treated With a Stable Dose of Metformin ClinicalTrials.gov · COMPLETED, 2007
• A 12 Week Multi Center, Open Label, Single Arm Study to Assess the Safety and Efficacy of Vildagliptin 50 mg Twice Daily in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin ClinicalTrials.gov · COMPLETED, 2011
• A Randomized, Double-blind Study of the Effect of the DPP-IV Inhibitor on HbA1c and Safety in Patients With Type 2 Diabetes Treated With a Stable Dose of Metformin ClinicalTrials.gov · COMPLETED, 2006
• A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Phase 3 Trial to Evaluate the Safety and Efficacy of Dapagliflozin as Monotherapy in Subjects With Type 2 Diabetes Who Have Inadequate Glycemic Control With Diet and Exercise ClinicalTrials.gov · COMPLETED, 2010
• Effects of Metformin on Body Weight, Composition and Metabolic Derangements in Obese Children. A Randomized Clinical Trial ClinicalTrials.gov · COMPLETED, 2016
• MK-0431/ONO-5435 Phase III Clinical Study - Metformin Add-On Study for Patients With Type 2 Diabetes Mellitus ClinicalTrials.gov · COMPLETED
• A Pilot Study: Metformin as an Inflammatory Modulating Therapy in Older Adults Without Diabetes ClinicalTrials.gov · COMPLETED, 2020
• The Effect of Metformin in Pregnant Women Who Received Antenatal Corticosteroids on Glycemic Control and the Rate of Neonatal Hypoglycemia - Multicenter Prospective Randomized, Controlled Trial ClinicalTrials.gov · COMPLETED, 2025
• Does Metformin Improve Pregnancy Outcomes (Incidence of LGA (≥90% Birth Weight Centile) Babies, Onset of Maternal GDM, Hypertension, PET, Macrosomia, Shoulder Dystocia, Admission to SCBU) in Obese Non-diabetic Women? ClinicalTrials.gov · COMPLETED, 2015