Browse studies, page 1223

Page 1223 of 1,286, newest first. Search them all at once, ranked by relevance, in Evidence Hub.

• Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: A systematic review, meta-analysis and meta-regression of randomized controlled trials Frontiers in Endocrinology, 2022
• Mechanism of metformin regulation in central nervous system: Progression and future perspectives Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022
• Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study Frontiers in Medicine, 2021
• Metformin activates AMPK/SIRT1/NF-κB pathway and induces mitochondrial dysfunction to drive caspase3/GSDME-mediated cancer cell pyroptosis Cell Cycle, 2020
• Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain Biochemical Journal, 2000
• Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK. Cell Reports, 2019
• Metformin prevents age-associated ovarian fibrosis by modulating the immune landscape in female mice Science Advances, 2022
• Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin Nature Communications, 2018
• Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway Redox Biology, 2020
• Metformin protects against myocardial ischemia-reperfusion injury and cell pyroptosis via AMPK/NLRP3 inflammasome pathway Aging, 2020
• Metformin limits osteoarthritis development and progression through activation of AMPK signalling Annals of the Rheumatic Diseases, 2020
• Metformin Treatment Was Associated with Decreased Mortality in COVID-19 Patients with Diabetes in a Retrospective Analysis American Journal of Tropical Medicine and Hygiene, 2020
• Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group Journal of the American Medical Association (JAMA), 1999
• Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota Nature, 2015
• Metformin alleviates oxidative stress and enhances autophagy in diabetic kidney disease via AMPK/SIRT1-FoxO1 pathway Molecular and Cellular Endocrinology, 2020
• Metformin Affects Gut Microbiome Composition and Function and Circulating Short-Chain Fatty Acids: A Randomized Trial Diabetes Care, 2021
• Effects of Long-term Metformin and Lifestyle Interventions on Cardiovascular Events in the Diabetes Prevention Program and its Outcome Study Circulation, 2022
• Metformin reverses established lung fibrosis in a bleomycin model Nature Medicine, 2018
• A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan Frontiers in Endocrinology, 2021
• Metformin and reduced risk of cancer in diabetic patients British medical journal, 2005
• The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin Science, 2005
• Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1 Molecules and Cells, 2018
• Long-term metformin therapy and vitamin B12 deficiency: An association to bear in mind World Journal of Diabetes, 2021
• Metformin attenuated sepsis-related liver injury by modulating gut microbiota Emerging Microbes and Infections, 2022
• Metformin: historical overview Diabetologia, 2017
• Mitochondria as an important target of metformin: the mechanism of action, toxic and side effects, and new therapeutic applications Pharmacological Research, 2022
• Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy International Journal on Biological Sciences, 2019
• Metformin and Insulin Resistance: A Review of the Underlying Mechanisms behind Changes in GLUT4-Mediated Glucose Transport International Journal of Molecular Sciences, 2022
• GDF15 mediates the effects of metformin on body weight and energy balance Nature, 2019
• Metformin: Is it a drug for all reasons and diseases? Metabolism: Clinical and Experimental, 2022
• Gut microbiota and intestinal FXR mediate the clinical benefits of metformin Nature Medicine, 2018
• Metformin and Its Benefits for Various Diseases Frontiers in Endocrinology, 2020
• Is it still worth pursuing the repurposing of metformin as a cancer therapeutic? British Journal of Cancer, 2023
• Benefits of Metformin in Attenuating the Hallmarks of Aging Cell Metabolism, 2020
• Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer Journal of experimental & clinical cancer research : CR, 2021
• Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation Immunity, 2021
• Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug Nature Medicine, 2017
• Cellular and Molecular Mechanisms of Metformin Action Endocrine reviews, 2020
• Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing Journal of Translational Medicine, 2023
• Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes Drug Design, Development and Therapy, 2023
• Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy New England Journal of Medicine, 2006
• pH/Glucose Dual Responsive Metformin Release Hydrogel Dressings with Adhesion and Self-Healing via Dual-Dynamic Bonding for Athletic Diabetic Foot Wound Healing ACS Nano, 2022
• Low-dose metformin targets the lysosomal AMPK pathway through PEN2 Nature, 2022
• The mechanisms of action of metformin Diabetologia, 2017
• Metformin: update on mechanisms of action and repurposing potential Nature Reviews Endocrinology, 2023
• Metformin decelerates aging clock in male monkeys Cell, 2024
• Role of AMP-activated protein kinase in mechanism of metformin action Journal of Clinical Investigation, 2001
• Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin New England Journal of Medicine, 2002
• Neuroprotective effects of empagliflozin and metformin combined therapy on rotenone induced Parkinsonism in Wistar rats via PI3K and PPARγ modulation Scientific reports, 2026
• Metformin Stabilizes the Abdominal Aorta in Aneurysm by Restoring VSMC Mitochondrial Homeostasis via the AMPK–SIRT1–PGC-1α Axis 2026
• Metformin potentiates arsenic disulfide in diffuse large B-cell lymphoma: modulation of BAX/BCL-2 apoptotic pathway and hedgehog pathway Frontiers in oncology, 2026
• Rate and Characteristics of Metformin Use in Gestational Diabetes Obstetrics and gynecology international, 2026
• Severe Metformin Intoxication Resulting in Extreme Lactic Acidosis Journal of medical cases, 2026
• Comparison between metformin and intermittent fasting for renoprotective effects through mitophagy modulation in a rat cisplatin-induced acute kidney injury model 2026
• Same Result, Different Price: Compounded versus Branded Tirzepatide 2026
• Oleanolic Acid as an Adjunct in Type 2 Diabetes 2026
• Exploring the therapeutic applications of metformin in articular cartilage repair: mechanistic insights and translational perspectives Frontiers in immunology, 2026
• Maternal metformin treatment in obese pregnant dams normalizes neonatal sensory-motor reflexes Molecular and cellular pediatrics, 2026
• Combination Therapy Potential of HTD1801 (Berbe-rine Ursodeoxycholate) in MASLD/MASH and Cardiovascular-Kidney-Metabolic Disease 2026
• Evaluating Metformin Efficacy in ALS Using Real-World Data: A Causal Inference Approach 2026
• Oral Wegovy Broadens Care Continuum Across First-Time GLP-Starters, High Cardiometabolic Burden GLP-Switchers, and Medicare-Age Patients 2026
• Metformin Suppresses Metastatic Potential and Sensitizes Ovarian Cancer Cells to Chemotherapeutics International journal of molecular sciences, 2026
• Off-Trial: Real-World Weight Loss on Tirzepatide and Semaglutide 2026
• Effectiveness of an educational intervention in the integral care of patients with diabetes mellitus 2026
• BSCL2-Associated Congenital Generalized Lipodystrophy: Real-World Data on Phenotype, Genotype, and Therapeutic Management 2026
• Therapeutic Potential of Anti-Obesity Drugs in Obesity-Associated Female Reproductive Dysfunction 2026
• Inter-organ communication shapes human metabolic tissue states and resolves anti-diabetic drug response modes in a six-tissue microphysiological system bioRxiv : the preprint server for biology, 2026
• Intracapsular metformin bioactivity and its role in posterior capsule opacification The British journal of ophthalmology, 2026
• Incident Frailty and Mortality Risk with Significant Tirzepatide-Associated Weight Loss in Medicare-Age Patients 2026
• Baicalin restores metformin responsiveness by inhibiting ceramide biosynthesis via SPT and pPP2A/pAMPK axis 2026
• Targeting Cancer Metabolism: Modulation of Metformin Antitumor Effects by Caffeine with Involvement of p53 Signaling 2026
• In-silico design of Phosphorus-doped endohedral fullerenes (Sc3P@C80) as sensors for anticancer drug: A DFT study of Metformin (MFM) adsorption Research Square, 2026
• Circulating microRNAs as Putative Causal Regulators of Peripheral Arterial Disease in Diabetic Foot: An Integrative Multi-Omics and Drug Repurposing Study 2026
• Metformin and Tirzepatide in Lipedema: Targeting Fibrosis and Inflammation Through Complementary Pathways. A Mechanistic, Translational and Therapeutic Perspective 2026
• Clinician awareness and implementation of MHRA guidance on vitamin B12 monitoring in metformin users: a reflexive thematic analysis of primary care practice 2026
• Transcriptome-Wide Identification of Hub Genes and Therapeutic Targets in Type 2 Diabetes Mellitus Through Integrated Bioinformatics and Molecular Docking-Based Drug Repurposing 2026
• Cytolethal distending toxin promotes epithelial-to-mesenchymal transition by modulating AKT-Dependent β-catenin Ser552 phosphorylation 2026
• Neurosensory Risk After Semaglutide or Tirzepatide Is Lower Than Matched Antidiabetic and Bariatric Surgery Cohorts and Tracks Glycemic Burden 2026
• Feasibility of Managing Diabetes Patients Identified Through Community Screening in Rural Ethiopia 2026
• Metformin as a Chemopreventive Agent for Colorectal Adenoma Recurrence: Evidence from Randomized Controlled Trials 2026
• Is Routine Metformin Discontinuation Necessary Before Elective Coronary Angiography? A Randomized Clinical Trial 2026
• Molecular Insights into the Interaction Between Metformin and Caffeine: Time-Dependent Antagonism and Modulation of p53 Signaling in Cancer Cells 2026
• Evidence for reduced migraine reporting with GLP-1 receptor agonists 2026
• Engineered trophoblast organoids recapitulate molecular and functional features of preeclampsia 2026
• Metformin Attenuates Behavioral Deficits and Oxidative Stress in a Preclinical Model of Autism Developmental neurobiology, 2026
• Can a Large Language Model Serve as the Missing Second Reviewer? Prominence Bias, Retrieval Effects, and a Confidence-Fabrication Gap in an Empirical Evaluation of Two Published Meta-Analyses 2026
• Comparative Effectiveness of Metformin versus GLP-1 Receptor Agonists in Treating Antipsychotic-Induced Metabolic Disturbances: A Systematic Review and Network Meta-Analysis 2026
• Effect of Metformin on Sleep Architecture in Patients with Comorbid Diabetes and Sleep Apnea 2026
• DrugSet: A validated R Shiny application for reproducible drug codelist construction from ATC classification to CPRD Aurum prodcodes 2026
• Enhanced Radio-sensitization of Glioblastoma using a Dendrimer-Based Metformin Nano-formulation through Direct Tumor Suppression and Indirect Immune Modulation bioRxiv : the preprint server for biology, 2026
• Machine Learning Modeling of D-Optimal Design Data for Metformin Hydrochloride Orally Disintegrating Tablets 2026
• Adjuvant S-1 Plus Metformin after Pancreatic Cancer Resection: A Multicenter Randomized Phase II Trial 2026
• Vitamin D Supplementation on Metabolic and Endocrine Profiles in Women with polyendocrine metabolic ovarian syndrome: An Updated Systematic Review and Meta-Regression of Randomized Controlled Trials 2026
• Additional effects of bariatric surgery and metformin on glucose regulation in non-obese insulin-deficient diabetic rats 2026
• Itaconate delays type 2 diabetes progression by alkylating RIPK3 to inhibit pancreatic β‑cell failure 2026
• Cancer Cell Line Heterogeneity Imposes a Primary Bottleneck for Virtual Perturbation Screening at Scale 2026
• Lower respiratory infections in diabetes: which hypoglycemic agents help and which harm? A drug-target Mendelian randomization study 2026
• Metformin Use, Inflammatory Markers, and Mortality in U.S. Adults with Type 2 Diabetes: A Nationally Representative Cohort Study Using NHANES 2013–2018 2026
• Twelve Hallmarks, One Target: The Metadichol® Approach to Systems-Level Aging 2026
• Preparation and use of activated carbon based on Pinus nigra cones 2026