Browse studies, page 1222

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• Multicentre, Randomised, Comparative, Open, Three Armed Parallel Group Study on the Use of Metformin, Repaglinide or the Combination of Both in Type 2 Diabetic Patients After Failure of Dietary Measures ClinicalTrials.gov · COMPLETED, 2004
• A Relative Bioavailability Study of 5 mg Glyburide/500 mg Metformin HCl Tablets Under Non-Fasting Conditions ClinicalTrials.gov · COMPLETED, 2002
• Diazoxide-mediated Insulin Suppression in Hyperinsulinemic Obese Men, Part III ClinicalTrials.gov · COMPLETED, 2011
• A Open-label, Single Sequence Clinical Trial to Investigate the Pharmacokinetic/Pharmacodynamic Drug-drug Interaction of Pyrimethamine and Metformin IR After Oral Administration in Healthy Male Volunteers ClinicalTrials.gov · COMPLETED
• A Multi-national, Open-labelled, Randomised, Parallel Group, 4 Week run-in and 26 Weeks Treat-to-target Comparison of Biphasic Insulin Aspart 30 Once Daily Versus Insulin Glargine Once Daily Both in Combination With Metformin and Glimepiride in Insulin naïve Subjects With Type 2 Diabetes ClinicalTrials.gov · COMPLETED, 2008
• Comparison of Two Therapeutic Strategies for Treating Type 2 Diabetic Patients Poorly Controlled With Basal Insulin Associated With Oral Antidiabetic Drugs : 6-month Proof of Concept Study ClinicalTrials.gov · COMPLETED, 2008
• Research of Intensive Lifestyle Intervention for Overweight PCOS Patients With Impaired Glucose Tolerance in Their Metabolic and Reproductive Abnormalities Treatment ClinicalTrials.gov · COMPLETED, 2018
• A Clinical Trial to Compare the Pharmacokinetic and Pharmacodynamic Characteristics and Safety After Oral Administration of Glucophage With Those After Oral Administration of HL-018 in Healthy Male Volunteers ClinicalTrials.gov · COMPLETED, 2010
• The Effect of Remote Self-monitoring of Blood Glucose (SMBG) Combined With the Promotion and Application of Internet Mobile Terminal (APP) on the Improvement of the Staged Type 2 Diabetes Mellitus (T2DM) Management and the Success Rate of Blood Glucose in the Community ClinicalTrials.gov · COMPLETED, 2021
• A Multicenter, Open-Label, Randomised Trial to Compare the Efficacy and Safety of NovoLog Mix 70/30 BID in Combination With Metformin and Pioglitazone to Metformin and Pioglitazone Alone in Insulin Naïve Subjects With Type 2 Diabetes ClinicalTrials.gov · COMPLETED, 2005
• A Randomised Controlled Trial for People With Established Type 2 Diabetes During Ramadan: Liraglutide vs. a Sulphonylurea ClinicalTrials.gov · COMPLETED, 2012
• Randomized Clinical Trial Evaluating the Impact of Pretreatment With Metformin on Colorectal Cancer Stem Cells (CCSC) and Related Pharmacodynamic Markers ClinicalTrials.gov · TERMINATED, 2012
• A Randomized, Open Label, Cross-over Clinical Trial to Investigate Pharmacokinetics and Drug Interaction of Crestor and Glucodown OR SR in Healthy Volunteers ClinicalTrials.gov · COMPLETED, 2012
• A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group, Phase 3 Trial to Evaluate the Safety and Efficacy of Once Weekly Exenatide Therapy Added to Titrated Basal Insulin Glargine Compared to Placebo Added to Titrated Basal Insulin Glargine in Patients With Type 2 Diabetes Who Have Inadequate Glycemic Control on Basal Insulin Glargine With or Without Metformin ClinicalTrials.gov · COMPLETED, 2016
• A 56-week, Multicenter, Open-label, Active-controlled, Randomized Study to Evaluate the Efficacy and Safety of Efpeglenatide Once Weekly Compared to Dulaglutide Once Weekly in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin ClinicalTrials.gov · TERMINATED, 2020
• Metformin for the Treatment of Endometrial Hyperplasia ClinicalTrials.gov · COMPLETED, 2015
• A Randomized, Phase 3, Open-label Trial Comparing the Effect of the Addition of Tirzepatide Once Weekly Versus Insulin Lispro (U100) Three Times Daily in Participants With Type 2 Diabetes Inadequately Controlled on Insulin Glargine (U100) With or Without Metformin (SURPASS-6) ClinicalTrials.gov · COMPLETED, 2022
• An Open, Comparative, Randomized, Crossover Bioequivalence Study of Single Doses of Metformin, Prolonged-release Tablets 500 mg (JSC Farmak, Ukraine) vs Glucophage® XR 500 mg in Healthy, Adult Male and Female Subjects Under Fed Conditions ClinicalTrials.gov · COMPLETED, 2019
• A Multicenter, Randomized, Double-blind, Double Dummy, Active-controlled, Therapeutic Confirmatory Trial(Phase 3) to Evaluate the Efficacy and Safety of CWP-0403 Compared With Sitagliptin Added to Ongoing Metformin Therapy in Patients With Type 2 DM Insufficiently Controlled With Metformin Alone ClinicalTrials.gov · COMPLETED, 2013
• Study to Evaluate the Effect of Metformin in the Prevention of Hyperglycemia in HR[+]/HER2[-] PIK3CA-mutation Advanced Breast Cancer Patients Treated With Alpelisib Plus Endocrine Therapy. Study Metallica ClinicalTrials.gov · COMPLETED, 2025
• The Effect of Januvia (Sitagliptin) on Oxidative Stress in Obese Type 2 Diabetic Subjects ClinicalTrials.gov · COMPLETED, 2013
• Comparison of the Efficacy on Glycaemic Control and Safety Profile of Biphasic Insulin Aspart 30 and Biphasic Human Insulin 30 Both in Combination With Metformin in Insulin-naïve Subjects With Type 2 Diabetes Mellitus Inadequately Controlled on Oral Antidiabetic Drugs (OADs) Therapy ClinicalTrials.gov · COMPLETED, 2009
• Multicenter Prospective Cohort Study of the Hypoglycemic Efficacy, Weight Control, and Safety in Newly-diagnosed Type 2 Diabetes: Triple Combination Therapy Using Metformin, Saxagliptin Plus Dapagliflozin Versus Premixed Insulin ClinicalTrials.gov · COMPLETED, 2019
• A Randomized, Placebo-controlled, Double-blind Multicenter Phase II Study to Investigate the Protectivity and Efficacy of Metformin Against Steatosis in Combination With FOLFIRI and Cetuximab in Subjects With First-line Palliative Treated, KRAS-Wild-Type, Metastatic Colorectal Cancer ClinicalTrials.gov · TERMINATED, 2014
• A Multicenter, Randomized, Double-Blind, Placebo- and Active-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of TAK-875 25 mg and 50 mg Compared to Placebo and Sitagliptin 100 mg When Used in Combination With Metformin in Subjects With Type 2 Diabetes ClinicalTrials.gov · TERMINATED, 2014
• Cross-over Study to Assess the Difference in Fasting Plasma Glucose (FPG) Between Vildagliptin (Galvus®/Eucreas®) and Sitagliptin (Januvia®/Janumet®) After Two Weeks ClinicalTrials.gov · COMPLETED, 2012
• A Phase II, Double Blind, Randomized, Placebo-Controlled Study of the Safety, Tolerance and Activity of HE3286 When Administered Orally for 12 Weeks to Adult Patients With Type 2 Diabetes Mellitus ClinicalTrials.gov · COMPLETED, 2010
• Randomized Clinical Trial to Evaluate Safety, Tolerability and PK-PD Profile of Metformin Glycinate 620 mg,1240 mg, 2480 mg and Metformin Chlorhydrate 1000 mg of One Single Dose, Multiple Dose and After Food Intake ClinicalTrials.gov · COMPLETED, 2013
• A Phase 3, Multicenter, Randomized, Double-Blind, Active-Controlled (Dapagliflozin), Parallel Group Efficacy and Safety Study of HTD1801 in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin Alone ClinicalTrials.gov · COMPLETED, 2025
• Effect of Metformin and Probiotics on Gut Microbiome in Healthy Subjects: a Randomized, Double-blind Study ClinicalTrials.gov · COMPLETED, 2019
• Effect of White Mulberry Leaf Extract Supplementation on Metabolic Markers in Overweight Adults With Early Metabolic Dysregulation Receiving Metformin ClinicalTrials.gov · COMPLETED, 2024
• Bedtime Insulin Glargine or Bedtime Neutral Protamine Lispro Combined With Sulfonylurea and Metformin in Type 2 Diabetes. A Randomized, Controlled Trial ClinicalTrials.gov · COMPLETED, 2008
• Phase 4 Study of Metformin on Obesity and Metabolic Disturbance in Patients Taking Clozapine ClinicalTrials.gov · TERMINATED, 2015
• Clinical Investigation of Herbal Formulation and Its Efficacy in Polycystic Ovarian Syndrome ClinicalTrials.gov · COMPLETED, 2026
• Comparison of Switching to Premixed Insulin With Add-on Rapid-acting Insulin in Poorly Controlled Type 2 Diabetes Treated With Basal Insulin ClinicalTrials.gov · COMPLETED, 2016
• Multi-Centre Randomised Controlled Trial of the Effectiveness of Metformin and Clomiphene Citrate for Treating Anovulatory Infertility in Women With Polycystic Ovary Syndrome ClinicalTrials.gov · COMPLETED, 2008
• Phase I Study of TAK-228 (MLN0128) in Combination With Metformin in Patients With Advanced Cancers ClinicalTrials.gov · COMPLETED, 2022
• A Phase III Randomized, Double-blind, Parallel Group Study to Evaluate the Efficacy and Safety of Once Daily Oral Administration of BI 10773 25 mg/Linagliptin 5 mg and BI 10773 10 mg/Linagliptin 5 mg Fixed Dose Combination Tablets Compared With the Individual Components (BI 10773 25 mg, BI 10773 10 mg, and Linagliptin 5 mg) for 52 Weeks in Treatment naïve and Metformin Treated Patients With Type 2 Diabetes Mellitus With Insufficient Glycaemic Control ClinicalTrials.gov · COMPLETED, 2013
• Efficacity and Safety of Metformin XR in CKD Stage 1 to 3 ClinicalTrials.gov · COMPLETED, 2022
• A Phase 1, Single-Center, Repeat-Dose, Open-Label, Fixed-Sequence Drug-Drug Interaction Study of ZX008 in Healthy Male Or Female Study Participants 18 To 55 Years Of Age ClinicalTrials.gov · COMPLETED, 2025
• Drug-Drug Interaction Study of Multiple Doses of Pacritinib and CYP450 And, Transporter Substrates, and CYP450 3A4 Inducers and Inhibitors ClinicalTrials.gov · COMPLETED, 2023
• Differences in Endothelial Function Amongst Sitagliptin and Liraglutide Users: A Randomized, Open-label, Parallel-group and Active Controlled Trial ClinicalTrials.gov · COMPLETED, 2014
• Monitoring Parameters Beyond Glycemic Control: Impact of Sitagliptin on Quality of Life in Type 2 Diabetes Patients ClinicalTrials.gov · COMPLETED, 2022
• Effect of Metformin With or Without Folate Addiction on Uterine Blood Flow and Trophoblastic Invasion in Pregnant Patients With Polycystic Ovary Syndrome ClinicalTrials.gov · COMPLETED, 2011
• Randomized, Open Label, Two Parallel Arms, Intervention Trial Comparing the Effect of DPP-IV Inhibitor Vildagliptin vs. Glibenclamide on Circulating Endothelial Progenitor Cell Number in Patients With Type 2 Diabetes in Metformin Failure ClinicalTrials.gov · COMPLETED, 2015
• Vildagliptin Compared to Glimepiride in Combination With Metformin in Patients With Type 2 Diabetes ClinicalTrials.gov · COMPLETED, 2008
• A Multicenter, Double-Blind, Randomized, Parallel-Group Study to Compare the Effect of 14 Weeks Treatment With LMF237 Bid to Placebo in Patients With Type 2 Diabetes Inadequately Controlled With Vildagliptin 50 mg Bid Monotherapy ClinicalTrials.gov · COMPLETED, 2014
• A 26-week Randomised, Confirmatory, Controlled, Open Label, Multicentre, Multinational Treat-to-target Trial Comparing the Efficacy and Safety of SIBA 200 U/ml Three Times Weekly Injected in the Evening and Insulin Glargine Once Daily in a Population of Insulin naïve Subjects With Type 2 Diabetes Mellitus Currently Treated With OADs Qualifying for Intensified Treatment (BEGIN™: EASY™) ClinicalTrials.gov · COMPLETED, 2010
• A Trial Comparing the Efficacy and Safety of Insulin Degludec Once Daily in Insulin naïve Subjects With Type 2 Diabetes Mellitus When Titrated Using Two Different Titration Algorithms (BEGIN™: ONCE SIMPLE USE) ClinicalTrials.gov · COMPLETED, 2011
• Effects of Combined Resveratrol and Myo-inositol on Altered Metabolic, Endocrine Parameters and Perceived Stress in Patients With Polycystic Ovarian Syndrome ClinicalTrials.gov · COMPLETED, 2021
• An Open Label, Multicenter Trial Assessing the Acceptability of a New Fixed Combination of Fenofibrate 80 mg BID and Metformin 1000 mg BID in Patients With Type 2 Diabetes and Dyslipidemia ClinicalTrials.gov · COMPLETED
• Pilot Trial of Chromium-Metformin Combination in Type 2 Diabetes: Impact on Blood Sugar Control and Insulin Resistance ClinicalTrials.gov · TERMINATED, 2007
• Myo-inositol Versus Metformin: Effects of Six Months Treatment on Clinical, Endocrine and Metabolic Features in Obese Women With Polycystic Ovary Syndrome ClinicalTrials.gov · COMPLETED, 2012
• A Single-Dose, Open-Label, Randomized, 3-Way Crossover Pivotal Study to Assess the Bioequivalence of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) (2 x 50 mg/500 mg) With Respect to the Individual Components of Canagliflozin (1 x 100 mg) and Metformin XR Tablet (2 x 500 mg) in Healthy Fed Subjects ClinicalTrials.gov · COMPLETED, 2014
• Improving Metabolic Parameters of Antipsychotic Child Treatment (IMPACT) ClinicalTrials.gov · COMPLETED, 2014
• Structural Alteration of Gut Microbiota during the Amelioration of Human Type 2 Diabetes with Hyperlipidemia by Metformin and a Traditional Chinese Herbal Formula: a Multicenter, Randomized, Open Label Clinical Trial mBio, 2018
• Metformin Enhances the Antitumor Activity of CD8+ T Lymphocytes via the AMPK–miR-107–Eomes–PD-1 Pathway Journal of Immunology, 2020
• Metformin induces human esophageal carcinoma cell pyroptosis by targeting the miR-497/PELP1 axis Cancer Letters, 2019
• Effects of Metformin on the Gut Microbiota in Obesity and Type 2 Diabetes Mellitus Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy, 2020
• Neonatal, infant, and childhood growth following metformin versus insulin treatment for gestational diabetes: A systematic review and meta-analysis PLoS Medicine, 2019
• Observational Study of Metformin and Risk of Mortality in Patients Hospitalized with Covid-19 medRxiv, 2020
• Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells Cell Reports, 2018
• Metformin as Anti-Aging Therapy: Is It for Everyone? Trends in endocrinology and metabolism, 2019
• Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase Nature, 2014
• Metformin and the gastrointestinal tract Diabetologia, 2016
• The Metformin Mechanism on Gluconeogenesis and AMPK Activation: The Metabolite Perspective International Journal of Molecular Sciences, 2020
• An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice Gut, 2013
• Metformin-associated lactic acidosis: Current perspectives on causes and risk Metabolism: Clinical and Experimental, 2016
• Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation Cell Metabolism, 2020
• Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy Cell, 2019
• COVID-19 and Risk of Acute Ischemic Stroke and Acute Lung Injury in Patients With Type II Diabetes Mellitus: The Anti-inflammatory Role of Metformin Frontiers in Medicine, 2021
• Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes Cell Metabolism, 2020
• Metformin induces cell cycle arrest, apoptosis and autophagy through ROS/JNK signaling pathway in human osteosarcoma International Journal on Biological Sciences, 2020
• Phase II clinical trial of metformin as a cancer stem cell-targeting agent in ovarian cancer JCI Insight, 2020
• Mechanism and application of metformin in kidney diseases: An update Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021
• Metformin attenuates silica-induced pulmonary fibrosis via AMPK signaling Journal of Translational Medicine, 2021
• The Intersection of Metformin and Inflammation American Journal of Physiology - Cell Physiology, 2021
• Metformin facilitates mesenchymal stem cell-derived extracellular nanovesicles release and optimizes therapeutic efficacy in intervertebral disc degeneration Biomaterials, 2021
• Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus Aging Cell, 2021
• Metformin, Macrophage Dysfunction and Atherosclerosis Frontiers in Immunology, 2021
• Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome Cochrane Database of Systematic Reviews, 2020
• Metformin: A Novel Weapon Against Inflammation Frontiers in Pharmacology, 2021
• Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis Cancer Cell, 2019
• Metformin: from mechanisms of action to therapies Cell Metabolism, 2014
• Metformin Use Is Associated With Slowed Cognitive Decline and Reduced Incident Dementia in Older Adults With Type 2 Diabetes: The Sydney Memory and Ageing Study Diabetes Care, 2020
• Effect of metformin on all-cause and cardiovascular mortality in patients with coronary artery diseases: a systematic review and an updated meta-analysis Cardiovascular Diabetology, 2019
• The Current and Potential Therapeutic Use of Metformin—The Good Old Drug Pharmaceuticals, 2021
• Metformin and Systemic Metabolism TIPS - Trends in Pharmacological Sciences, 2020
• Cellular and molecular mechanisms of metformin: an overview Clinical science, 2012
• Should metformin remain the first-line therapy for treatment of type 2 diabetes? Therapeutic Advances in Endocrinology and Metabolism, 2021
• Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis Nature Communications, 2019
• Role of Mitochondria in the Mechanism(s) of Action of Metformin Frontiers in Endocrinology, 2019
• The beneficial effects of metformin on cancer prevention and therapy: a comprehensive review of recent advances Cancer Management and Research, 2019
• Metformin use and prostate cancer risk: A meta-analysis of cohort studies Medicine, 2019
• Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model Protein & Cell, 2021
• The effects of metformin on autophagy Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021
• Metformin: Mechanisms in Human Obesity and Weight Loss Current Obesity Reports, 2019
• Targeting BCAA metabolism to potentiate metformin's therapeutic efficacy in the treatment of diabetes in mice Cell Metabolism, 2016
• Metformin as an emerging concern in wastewater: Occurrence, analysis and treatment methods Environmental Research, 2022
• Metformin Restores Tetracyclines Susceptibility against Multidrug Resistant Bacteria Advancement of science, 2020