Browse studies, page 1016

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Melatonin and Melatonergic Drugs on Sleep: Possible Mechanisms of Action International Journal of Neuroscience, 2009
Melatonin for the Treatment of Sleep Disturbances in Major Depressive Disorder American Journal of Psychiatry, 1998
Peak of circadian melatonin rhythm occurs later within the sleep of older subjects American Journal of Physiology-Endocrinology and Metabolism, 2002
Sleep-Promoting and Hypothermic Effects of Daytime Melatonin Administration in Humans SLEEP, 1997
Sleep dysfunction in Rett syndrome: a trial of exogenous melatonin treatment Developmental Medicine & Child Neurology, 1998
The Role of Melatonin and Circadian Phase in Age-related Sleep-maintenance Insomnia: Assessment in a Clinical Trial of Melatonin Replacement SLEEP, 1998
Melatonin: Role in Gating Nocturnal Rise in Sleep Propensity Journal of Biological Rhythms, 1997
Atopic Dermatitis, Melatonin, and Sleep Disturbance PEDIATRICS, 2014
The role of actigraphy in the study of sleep and circadian rhythms SLEEP, 2003
Melatonin therapy for REM sleep behavior disorder Psychiatry and Clinical Neurosciences, 2001
Obesity and metabolic syndrome: Association with chronodisruption, sleep deprivation, and melatonin suppression Annals of Medicine, 2011
The role of the thalamus in sleep, pineal melatonin production, and circadian rhythm sleep disorders Journal of Pineal Research, 2008
Role of the melatonin system in the control of sleep: therapeutic implications CNS Drugs, 2007
EEG and ocular correlates of circadian melatonin phase and human performance decrements during sleep loss American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1999
Use of melatonin in the treatment of paediatric sleep disorders Journal of Pineal Research, 1996
Melatonin: A Sleep-Promoting Hormone SLEEP, 1997
The Durations of Human Melatonin Secretion and Sleep Respond to Changes in Daylength (Photoperiod) The Journal of Clinical Endocrinology & Metabolism, 1991
Melatonin as a therapy in rem sleep behavior disorder patients: An open-labeled pilot study on the possible influence of melatonin on rem-sleep regulation Movement Disorders, 1999
Sleep disturbance and melatonin levels following traumatic brain injury Neurology, 2010
Melatonin, Circadian Rhythms, and Sleep New England Journal of Medicine, 2000
The use of exogenous melatonin in delayed sleep phase disorder: a meta-analysis SLEEP, 2010
Melatonin and the Circadian Regulation of Sleep Initiation, Consolidation, Structure, and the Sleep EEG Journal of Biological Rhythms, 1997
Sleep disorders and melatonin rhythms in elderly people BMJ, 1994
Sleep-inducing effects of low doses of melatonin ingested in the evening* Clinical Pharmacology & Therapeutics, 1995
Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms The Journal of Physiology, 1999
Circadian temperature and melatonin rhythms, sleep, and neurobehavioral function in humans living on a 20-h day American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1999
Effects of Sleep and Sleep Deprivation on Interleukin-6, Growth Hormone, Cortisol, and Melatonin Levels in Humans1 The Journal of Clinical Endocrinology & Metabolism, 2000
The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis Journal of General Internal Medicine, 2005
A Multicenter, Placebo-controlled Trial of Melatonin for Sleep Disturbance in Alzheimer's Disease SLEEP, 2003
The treatment of sleep disorders with melatonin Developmental Medicine & Child Neurology, 1994
Effect of melatonin on sleep, behavior, and cognition in ADHD and chronic sleep-onset insomnia Journal of the American Academy of Child & Adolescent Psychiatry, 2007
Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis BMJ, 2006
Melatonin and sleep in humans Journal of Pineal Research, 1993
Meta-analysis: melatonin for the treatment of primary sleep disorders PLoS ONE, 2013
Effects of exogenous melatonin on sleep: a meta-analysis Sleep Medicine Reviews, 2004
Role of Melatonin in the Regulation of Human Circadian Rhythms and Sleep Journal of Neuroendocrinology, 2003
Sleep hygiene and melatonin treatment for children and adolescents with ADHD and initial insomnia PubMed, 2006
Effect of Melatonin on Postoperative Pain After Simple Nephrectomy: A Randomized Double-Blinded Controlled Study ClinicalTrials.gov · COMPLETED, 2025
Sleep Length and Circadian Regulation in Humans ClinicalTrials.gov · COMPLETED, 2014
Effects of Probiotics on Sleep Quality Among Mildly Stressed Adults: A Randomized, Placebo-controlled, Double-blind, Parallel Trial ClinicalTrials.gov · COMPLETED, 2023
Improving Sleep Quality, Psychosocial Functioning, and Cancer Related Fatigue With Light Therapy ClinicalTrials.gov · COMPLETED, 2020
Effect of Subanesthetic Dose of Esketamine on Sleep Quality and Recovery of Gastrointestinal Function in Patients Undergoing General Anesthesia Laparoscopic Uterine Surgery in the Early Postoperative Period ClinicalTrials.gov · COMPLETED, 2023
The Effect of Ear Plug and Eye Mask on Sleeping Quality in Critically Ill Patients ClinicalTrials.gov · COMPLETED, 2017
Effect of Continuous Versus Cyclic Daytime Enteral Nutrition on Circadian Rhythms in Critical Illness: CIRCLES Study ClinicalTrials.gov · COMPLETED, 2025
Assessment of the Effects of a Dietary Supplement on the Sleep Health and Sleep Quality of People With Sleep Problems: A Randomized, Double-blind, Placebo-controlled, Crossover Design Study ClinicalTrials.gov · COMPLETED, 2022
This is a Study Exploring the Reasons Why People With Alcohol Dependence Have Sleep Disturbances, and Whether or Not a Study Medication, Gabapentin, vs. Placebo, Affects Those Sleep Patterns ClinicalTrials.gov · COMPLETED, 2011
Impact of the Use a Multifaceted Intervention of Environment Control in the ICU to Optimize Quantity and Quality of Sleep in Critically Ill Patients ClinicalTrials.gov · COMPLETED, 2025
Is a Combination of Melatonin and Aminoacids Useful to Sarcopenic Elderly Patients? A Randomized Trial ClinicalTrials.gov · COMPLETED, 2015
Effect of Melatonin Patches on Sleep Quality in Patients Undergoing Urological Surgery ClinicalTrials.gov · COMPLETED, 2025
Randomized Clinical Trial: Effects of Melatonin Supplementation on Sleep Quality in Patients With Advanced Glaucoma ClinicalTrials.gov · COMPLETED, 2024
Exploring the Relationship Between Heart Rate Variability (HRV), Training Load, and Exercise Performance ClinicalTrials.gov · COMPLETED, 2024
Increased Protein at Breakfast for Weight Management in Overweight Adolescents ClinicalTrials.gov · COMPLETED, 2023
Postoperative Sleep Quality Following Total Joint Arthroplasty: A Prospective, Randomized, Controlled Trial of Diphenhydramine and Melatonin Versus Sleep Skills Training ClinicalTrials.gov · COMPLETED, 2022
Pilot Randomized-controlled Phase-IIa Trial on the Prevention of Comorbid Depression and Obesity in Attention-deficit/ Hyperactivity Disorder ClinicalTrials.gov · COMPLETED, 2020
Effect of Pistachio (Pistacia Vera L.) Consumption on Locomotor Activity and Molecular Regulation of the Circadian Clock in Adipose Tissue of Overweight Adults ClinicalTrials.gov · COMPLETED, 2021
Effect of Melatonin Supplementation on Excecutive Functions, Sleep Quality and Glycemic Metrics Among Adolescents With Type 1 Diabetes Mellitus ClinicalTrials.gov · COMPLETED, 2026
Evaluation of Circadian OS Technology on Melatonin Suppression ClinicalTrials.gov · COMPLETED, 2025
Study of Eating Patterns With a Smartphone App and the Metabolic Effects of Time Restricted Feeding (TRF) in the Metabolic Syndrome - An Open-label Randomized Controlled Trial of TRF vs Regular Dietary Advices ClinicalTrials.gov · COMPLETED, 2022
Mechanism Underlying the Effects of Blue Light in Humans ClinicalTrials.gov · COMPLETED, 2007
Does Melatonin Improve Neurocognitive Function, Cardiovascular Outcomes and Control of Breathing in Untreated Obstructive Sleep Apnea? ClinicalTrials.gov · TERMINATED, 2018
Eat Walnuts and Sleep Better: Exploring the Potential Role of Walnuts as Sleep-promoting Food and Their Impact on Body Composition ClinicalTrials.gov · COMPLETED, 2023
Effect of Sleep Timing, Independent of Duration, on Food Intake and Metabolic Control of Energy Balance ClinicalTrials.gov · COMPLETED, 2013
A Circadian Medicine Light-based Intervention for Obsessive-compulsive Disorder (OCD) ClinicalTrials.gov · COMPLETED, 2024
The Effects of Acute vs. Chronic of Screen Illumination on: Sleep Efficacy and Architecture, Physiology, Emotion and Behavior: Possible Effect on Human Health ClinicalTrials.gov · COMPLETED, 2016
Melatonin for Alcohol Use Disorder Patients With Sleeping Problems ClinicalTrials.gov · COMPLETED, 2019
A Study of Two Different Light Conditions for Healthy Subjects Above 65 Years ClinicalTrials.gov · COMPLETED, 2013
Study of add-on Ramelteon Therapy on Sleep and Circadian Rhythm Disruption in Patients With Schizophrenia ClinicalTrials.gov · COMPLETED, 2018
Comparison of Efficacy of Dexmedetomidine and Melatonin for Sleep Induction for Electroencephalography in Children ClinicalTrials.gov · COMPLETED, 2022
Randomized Double-Blind Pilot Study to Examine the Effects of a Localized Body Cooling Technology on Sleep and Metabolism in African, American With Overweight and Obesity ClinicalTrials.gov · COMPLETED, 2025
A Double-blind, Parallel Group, Randomized, Placebo Controlled Sleep Laboratory Study of Efficacy and Safety of Neu-P11 in Insomnia Patients Aged 18-80 ClinicalTrials.gov · COMPLETED, 2013
Characterization of Behavioral Disorders and 24 H-melatonin Level in Adults With Smith Magenis Syndrome ClinicalTrials.gov · COMPLETED, 2019
The Placebo Controlled Randomized Double Blind Multicenter Study to Investigate Effectiveness and Safety of Combination Use of Melatonin Receptor Agonist for Dose Reduction or Interruptions of BZD and Non-BZD Hypnotics on Chronic Insomnia ClinicalTrials.gov · COMPLETED, 2020
Melatonin and Sleep in Preventing Delirium in the Hospital: A Randomized Placebo-controlled Trial ClinicalTrials.gov · COMPLETED, 2016
A Double-blind, Parallel Group, Randomised, Placebo Controlled, Multicenter, Bridging Study of Efficacy and Safety of KI1001 in the Improvement of Sleep Quality in ≥ 55 Years Old Insomnia Patients ClinicalTrials.gov · COMPLETED, 2014
Effects of Higher Consumption of Protein-rich Animal Foods With the USDA Healthy U.S.-Style Eating Pattern on Sleep Quality and Cardio-metabolic Health in Overweight/Obese Adults During Diet-induced Weight Loss ClinicalTrials.gov · COMPLETED, 2019
Efficacy and Safety of Melatonin and Rivotril Treatment for Idiopathic Rapid Eye Movement Sleep Disorder: Prospective Randomized Study ClinicalTrials.gov · COMPLETED, 2020
Effect of Sleep on the Recovery of Patients Admitted to the ICU ClinicalTrials.gov · COMPLETED, 2020
Controlled-Release Melatonin (Melatonin CR)for the Treatment of Impaired Sleep Maintenance (ISM) in 4-8 Year Old Children With Autism Spectrum Disorders (ASD) ClinicalTrials.gov · TERMINATED, 2010
Integrated Chronotherapy for Perinatal Depression ClinicalTrials.gov · COMPLETED, 2019
Postoperative Melatonin Administration and Delirium Prevention in Patients Undergoing Vascular and Cardiac Surgery ClinicalTrials.gov · COMPLETED, 2013
Identifying the Pathophysiology of Neurogenic Orthostatic Hypotension and the Effects of Melatonin on Reducing Supine Hypertension in Peripherally Intact Versus Denervated Post-ganglionic Sympathetic Nerves ClinicalTrials.gov · TERMINATED, 2019
MTNR1B SNP*Food Timing Interaction on Glucose Control in a Late Eater Mediterranean Population ClinicalTrials.gov · COMPLETED, 2020
A Randomized, Double-blind Placebo-controlled, Parallel Group Study to Study the Efficacy and Tolerability of Ramelteon (Rozerem) in the Prophylaxis of Migraine ClinicalTrials.gov · TERMINATED, 2010
Sleep and Circadian Rhythms in Mechanically Ventilated Patients: a Feasibility and Mechanistic Study ClinicalTrials.gov · COMPLETED, 2008
Melatonin Treatment for Night-Eating Syndrome ClinicalTrials.gov · TERMINATED, 2017
Multicenter, Randomized, Double-blind, Parallel-group, Placebo Controlled, Study to Evaluate the Effects of Melatonin (Somnage®- Food Supplement) in the Management on Sleep Quality and Mood Alteration in Cancer Patients ClinicalTrials.gov · TERMINATED, 2018
Tart Cherry Juice for Sleep in Older Adults With Insomnia: A Pilot Study of Feasibility and Comprehensive Mechanisms ClinicalTrials.gov · COMPLETED, 2025
The Efficacy of Melatonin in Sleep Problems of Hemodialysis and Peritoneal Dialysis Patients ClinicalTrials.gov · COMPLETED, 2007
A Randomized, Placebo-controlled Study to Investigate the Efficacy and Safety of Circadin® to Alleviate Sleep Disturbances in Children With Neurodevelopmental Disabilities ClinicalTrials.gov · COMPLETED, 2018
Effect of a Novel Melatonin Supplement on Sleep Quality ClinicalTrials.gov · COMPLETED, 2024
Morning Light Treatment at Home to Improve Glucose Metabolism in People at Increased Risk for Type 2 Diabetes ClinicalTrials.gov · COMPLETED, 2019
The Therapeutic Effect of Melatonin in Pediatric Patients With Functional Dyspepsia ClinicalTrials.gov · COMPLETED, 2015
Operational Evaluation of a Photic Countermeasure to Improve Alertness, Performance, and Mood During Nightshift Work on a 105-day Simulated Human Exploration Mission to Mars ClinicalTrials.gov · COMPLETED, 2013
A Double-Blind, Randomized, Placebo-Controlled Study of Various Cannabinoids on Sleep Quality ClinicalTrials.gov · COMPLETED, 2024
Effects of Light Therapy on Sleep, Melatonin Rhythm and Mood in Hemodialysis Patients ClinicalTrials.gov · COMPLETED, 2010
Strength Training Effects on Musculoskeletal Health, Melatonin, Rest-activity Rhythms and Quality of Life: Muscle:Time Study ClinicalTrials.gov · COMPLETED, 2023
Day-night Rhythm in Muscle Metabolism of Prediabetic Subjects ClinicalTrials.gov · COMPLETED, 2019
A Randomized Cross Over Trial About the Influence of Skin Temperature Gradient on the Variation of Metabolic Hormones in Climates With Different Ambient Air Temperatures ClinicalTrials.gov · COMPLETED, 2018
The Effects of Methylphenidate on Sleep Patterns in Adults With ADHD: An Open Label Polysomnographic Study ClinicalTrials.gov · COMPLETED, 2007
A Phase 2 Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Dose-Ranging Study to Evaluate the Phase-Shifting Effects of Repeated Daily Dosing of Ramelteon in Healthy Subjects ClinicalTrials.gov · COMPLETED, 2005