Browse studies, page 694
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- Computational View toward the Inhibition of SARS-CoV-2 Spike Glycoprotein and the 3CL Protease Computation, 2020
- PDE5 inhibitor drugs for use in dementia Alzheimer s & Dementia Translational Research & Clinical Interventions, 2023
- A contemporary review on the important role of in silico approaches for managing different aspects of COVID-19 crisis Informatics in Medicine Unlocked, 2022
- A focus on riociguat in the treatment of pulmonary arterial hypertension Basic & Clinical Pharmacology & Toxicology, 2019
- Devoloppement of new in-silico screening methods in chemogenomics theses.fr (ABES), 2012
- Innovative methodologies for the purification of polluted water CINECA IRIS Institutional Research Information System (University of Basilicata), 2026
- Real world clinical perspective on PDE5i utility in dementia Alzheimer s & Dementia, 2022
- Flunarizine As a Candidate for Drug Repurposing Against Human Pathogenic Mammarenaviruses Preprints.org, 2024
- The Analysis of Primer Gene of Phosphodiesterase Type 5 (PDE5) on Erectyle Dysfungction Open Journal of Applied Sciences, 2018
- Multi-reference Computational Method for De-novo Design, Optimization, and Repositioning of Pharmaceutical Compounds Illustrated by Identifying Multi-target SARS-CoV-2 Ligands Research Square, 2021
- Male mice treated with combined anti-fibrotic therapeutics, IPW5371 and tadalafil, are predisposed to adverse cardiovascular events Frontiers in Pharmacology, 2025
- RP-HPLC-Based Stability-Indicating Analytical Method for Concurrent Determination of Finasteride and Tadalafil: Development and Validation International Journal of Drug Delivery Technology, 2025
- Industry-Patient-Friendly Tadalafil Oral Spray: Statistical Development, Functionality and In-Vivo Taste Assessment Hacettepe University Journal of the Faculty of Pharmacy, 2025
- Análises histopatológicas E imunohistoquímicas DO tadalafil sobre encefalopatia diabética experimental Editora Conhecimento Livre eBooks, 2023
- Effect of Ticagrelor, a Cytochrome P450 3A4 Inhibitor, on the Pharmacokinetics of Tadalafil in Rats Pharmaceutics, 2019
- Comparison of tadalafil pharmacokinetics after administration of a new orodispersible film versus a film-coated tablet Drug Design, Development and Therapy, 2018
- In Silico Mapping of Essential Residues in the Catalytic Domain of PDE5 Responsible for Stabilization of Its Commercial Inhibitors Scientia Pharmaceutica, 2019
- Phosphodiesterase- 5 (PDE5) Inhibitory Potential of Major Phytochemicals of Withania somnifera and Cardiospermum halicacabum: an in silico comparison with approved PDE5 inhibitors 2023
- In silico ADMET Profiling of Flavonoids as Potential Phosphodiesterase-5 Inhibitors in the Management of Erectile Dysfunction Tropical Journal of Drug Research, 2026
- COVID-19 and Phosphodiesterase Enzyme Type 5 Inhibitors Journal of microscopy and ultrastructure, 2020
- The anti-depressant effects of a novel PDE4 inhibitor derived from resveratrol Pharmaceutical biology, 2021
- A review on in silico virtual screening methods in COVID-19 using anticancer drugs and other natural/chemical inhibitors Exploration of targeted anti-tumor therapy, 2023
- Aphrodisiac Principles and other Constituents from the Roots of Panax quinguefolium and Panax ginseng ACS omega, 2024
- Computational drug repurposing reveals Alectinib as a potential lead targeting Cathepsin S for therapeutic developments against cancer and chronic pain Frontiers in bioinformatics, 2025
- Role of interaction mode of phenanthrene derivatives as selective PDE5 inhibitors using molecular dynamics simulations and quantum chemical calculations Molecular diversity, 2025
- Flunarizine as a Candidate for Drug Repurposing Against Human Pathogenic Mammarenaviruses Viruses, 2025
- A multi-modal approach to investigate Desmodium gangeticum's influence on stress-induced male infertility: In vivo, in vitro, and in silico assessments Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2024
- Logic-based modeling and drug repurposing for the prediction of novel therapeutic targets and combination regimens against E2F1-driven melanoma progression BMC chemistry, 2023
- A multi-reference poly-conformational method for in silico design, optimization, and repositioning of pharmaceutical compounds illustrated for selected SARS-CoV-2 ligands PeerJ, 2022
- Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease ACS chemical neuroscience, 2018
- Toward Natural Products-Based Drug Development for Erectile Dysfunction: A Molecular Candidate from Plant Tribulus terrestris Identified by an Integrated In Silico Study Omics : a journal of integrative biology, 2025
- A comparison study of macrocyclic hosts functionalized reduced graphene oxide for electrochemical recognition of tadalafil Biosensors & bioelectronics, 2017
- Ab Initio QM/MM Study Shows a Highly Dissociated SN2 Hydrolysis Mechanism for the cGMP-Specific Phosphodiesterase-5 Journal of chemical theory and computation, 2014
- Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives European journal of medicinal chemistry, 2012
- Key features for designing phosphodiesterase-5 inhibitors Journal of biomolecular structure & dynamics, 2010
- Q817G mutation in phosphodiesterase type 5: Conformational analysis and dissociation profile of the inhibitor Tadalafil Chemical biology & drug design, 2019
- In silico screening of anthraquinones from Prismatomeris memecyloides as novel phosphodiesterase type-5 inhibitors (PDE-5Is) Revista internacional de andrologia, 2018
- Exploring the binding mechanisms of PDE5 with chromeno[2,3-c]pyrrol-9(2H)-one by theoretical approaches RSC advances, 2018
- The molecular basis for the selectivity of tadalafil toward phosphodiesterase 5 and 6: a modeling study Journal of chemical information and modeling, 2013
- Extending the use of tadalafil scaffold: Development of novel selective phosphodiesterase 5 inhibitors and histone deacetylase inhibitors Bioorganic chemistry, 2020
- Molecular Docking Analysis of Anti-Severe Acute Respiratory Syndrome-Coronavirus 2 Ligands against Spike Glycoprotein and the 3-Chymotrypsin-Like Protease Journal of medical signals and sensors, 2021
- Fluorescent Detection of Tadalafil Based on Competitive Host-Guest Interaction Using p-Sulfonated Calix[6]arene Functionalized Graphene ACS applied materials & interfaces, 2015
- Searching for target-specific and multi-targeting organics for Covid-19 in the Drugbank database with a double scoring approach Scientific reports, 2020
- In silico design of novel hERG-neutral sildenafil-like PDE5 inhibitors Journal of biomolecular structure & dynamics, 2017
- In silico prediction of novel phosphodiesterase type-5 inhibitors derived from Sildenafil, Vardenafil and Tadalafil Bioorganic & medicinal chemistry, 2008
- Fluorometric detection of protein-ligand engagement: The case of phosphodiesterase5 Journal of pharmaceutical and biomedical analysis, 2018
- Effects of tadalafil on skeletal muscle tissue: exploring interactions and novel mechanisms of action Minerva Endocrinology, 2022
- Modification Tadalafil and Macitentan tablets to aerosol Frontiers in Bioscience-Landmark, 2022
- Nanosphere-loaded tadalafil with enhanced oral bioavailability: innovative application of electrohydrodynamic technique International Journal of Current Pharmaceutical Research, 2020
- Formulation and evaluation of solid dispersion of tadalafil International Journal of Drug Regulatory Affairs, 2018
- Differential vasoactive effects of sildenafil and tadalafil on cerebral arteries –relevant to migraine? BMC Pharmacology, 2011
- Tadalafil-loaded PLGA microspheres for pulmonary administration: preparation and evaluation Figshare, 2022
- The role of Tadalafil in treatment of infertility Asian Pacific Journal of Reproduction, 2012
- Improvement of Tadalafil Solubility through Microwave-Assisted Cyclodextrin Complexation Journal of Pharma Insights and Research., 2025
- Formulation development of immediate release pellets of tadalafil: solidification approach for nanosuspension International Journal of Applied Pharmaceutics, 2019
- Enhancement of solubility of tadalafil by cocrystal approach International Research Journal of Pharmacy, 2016
- Formulation, optimization and evaluation of oral dissolving films of tadalafil solid dispersion International Journal of Biology Pharmacy and Allied Sciences, 2023
- Tadalafil-loaded PLGA microspheres for pulmonary administration: preparation and evaluation Brazilian Journal of Pharmaceutical Sciences, 2019
- Plasma Concentrations of Tadalafil in Children With Pulmonary Arterial Hypertension Therapeutic Drug Monitoring, 2014
- Tadalafil for the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia: Pathophysiology and mechanism(s) of action Neurourology and Urodynamics, 2011
- Phosphodiesterase Type 5 Expression in Human and Rat Lower Urinary Tract Tissues and the Effect of Tadalafil on Prostate Gland Oxygenation in Spontaneously Hypertensive Rats The Journal of Sexual Medicine, 2011
- Differential effects of selective PDE5 inhibitors in rat cerebral arteries in vitro and in vivo BMC Pharmacology, 2009
- Inhaled roflumilast and tadalafil supress airway reactivity and inflammation in ovalbumin-sensitized guinea pigs 2016
- Formulation Development and Evaluation of Tadalafil Transdermal Patches Using Various Penetration Enhancers 2016
- Formulation and evaluation of mouth dissolving film of tadalafil Journal of Drug Delivery and Therapeutics, 2017
- Formulation and evaluation of nanosuspensions of tadalafil using different stabilizers European Chemical Bulletin, 2018
- Formulation of Double-layer Tadalafil and Amlodipine Complex Tablets to Treat Erectile Dysfunction and Hypertension Porrime, 2019
- Solubility enhancement, formulation development and evaluation of immediate release tablet of antihypertensive drug tadalafil Journal of Drug Delivery and Therapeutics, 2018
- Three-dimensional models of Mycobacterium tuberculosis proteins Rv1555, Rv1554 and their docking analyses with sildenafil, tadalafil, vardenafil drugs, suggest interference with quinol binding likely to affect protein's function BMC Structural Biology, 2018
- Bioenhanced advanced third generation solid dispersion of tadalafil: Repurposing with improved therapy in pyelonephritis Asian Journal of Pharmaceutical Sciences, 2017
- Design and evaluation of fast dissolving tablet containing tadalafil solid dispersion Journal of Critical Reviews, 2020
- Effect of surfactants and drug load on physico‐mechanical and dissolution properties of nanocrystalline tadalafil‐loaded oral films European Journal of Pharmaceutical Sciences, 2017
- Co-administration of sodium hydrosulfide and tadalafil modulates hypoxia and oxidative stress on bladder dysfunction in a rat model of bladder outlet obstruction International Brazilian Journal of Urology, 2022
- Tadalafil Attenuates Angiotensin II-Induced Extracellular Matrix Remodeling in Cardiac Fibroblasts Through TGF-β1/Smad3 Signaling Pathway Journal of Biomedical Nanotechnology, 2023
- In Vitro Assessment of Pharmacokinetic Drug-Drug Interactions of Direct Oral Anticoagulants: Type 5-Phosphodiesterase Inhibitors Are Inhibitors of Rivaroxaban and Apixaban Efflux by P-Glycoprotein Journal of Pharmacology and Experimental Therapeutics, 2018
- (42) treatment of acute phase of peyronie’s disease with tamoxifen and vardenafil/tadalafil OFF label Journal of Sexual Medicine, 2023
- Tadalafil Rescues the p.M325T Mutant of Best1 Chloride Channel Molecules, 2023
- Effect of phosphodiesterase type 5 inhibitors on sperm motility and acrosome reaction: An in vitro study Investigative and Clinical Urology, 2021
- Combination of alfuzosin and tadalafil exerts in vitro an additive relaxant effect on human corpus cavernosum Journal of Sexual Medicine, 2008
- Formulation and Evaluation of Tadalafil- Loaded Nano-Ointment and Cream for Raynaud’s Phenomenon Asian Journal of Pharmaceutics, 2024
- Effect of Tadalafil on Cytochrome P450 3A4–mediated Clearance: Studies in Vitro and in Vivo Clinical pharmacology and therapy, 2005
- Three Strikingly Different Crystal Habits of Tadalafil: Design, Characterization, Pharmaceutical Performance, and Computational Studies Molecular Pharmaceutics, 2024
- Tadalafil Enhances the Therapeutic Efficacy of Mesenchymal Stem Cells-Derived Exosomes in Pulmonary Hypertension by Upregulating miR-29a-3p International Journal of Nanomedicine, 2024
- Tailored transethosomal systems for tadalafil transdermal delivery: Impact of Phosal and edge activators on skin permeation and cellular uptake International Journal of Pharmaceutics: X, 2025
- Preparation and characterization of tadalafil-loaded hydrogel: An in-vivo evaluation of wound healing activity Pharmaceutical Science Advances, 2025
- Revealing the impact of tadalafil-loaded proniosomal gel against dexamethasone-delayed wound healing via modulating oxido-inflammatory response and TGF-β/Macrophage activation pathway in rabbit model PLoS ONE, 2025
- Forced degradation studies, quantification and in-vitro dissolution studies of tadalafil by spectrofluorimetry 2013
- Effects of Tadalafil and Sildenafil on HIV infection in vitro Journal of Human Virology & Retrovirology, 2015
- Effect of acute tadalafil on sperm motility and acrosome reaction: in vitro and in vivo studies Andrologia, 2014
- Mechanism investigation of highly selective inhibitors toward phosphodiesterase 5 and 6 via the in vitro calculation and simulation Frontiers in Chemistry, 2024
- #2161 Phosphodiesterase V inhibitor attenuates the fibrotic gene expression of human renal fibroblast derived from IgA nephropathy: an in-vitro study Nephrology, Dialysis and Transplantation, 2024
- Oral solid self-emulsifying system containing non oncology drug combination for repurposing in melanoma treatment: In vitro cytotoxicity, and in vivo hematotoxicity and pharmacokinetic study Journal of Research in Pharmacy, 2024
- In Vitro and In Vivo Studies of Titanium Dioxide Nanoparticles with Galactose Coating as a Prospective Drug Carrier ACS Omega, 2024
- Is the cyclic AMP specific phosphodiesterase type 4 (PDE4) a NEW pharmacological target in the human prostate? an in vitro approach Journal of Sexual Medicine, 2025
- Molecular mechanisms regulating PDE11A4 age-related liquid-liquid phase separation (LLPS) and its reversal by selective, potent and orally-available PDE11A4 small molecule inhibitors both in vitro and in vivo bioRxiv, 2025
- PO-01-012 Tadalafil modulates aromatase and androgem receptor expression in human prostatic adenocarcinoma cells in vitro Journal of Sexual Medicine, 2019
- Degradable Hydrogel Microspheres for Drug Delivery: In Vitro Performance and Influence of E-Beam Sterilization AAPS PharmSciTech, 2025
- RP-HPLC-PDA method development and validation for the analysis of Tadalafil in bulk, pharmaceutical dosage forms and in-vitro dissolution samples Journal of Applied Pharmaceutical Science, 2014
- The effect of phosphodiesterase-5 inhibitor, tadalafil, on in vitro potassium chloride-induced contractions of isolated human ureteral tissue Indian Journal of Urology, 2018
- In vitro and in vivo behavior of ground tadalafil hot-melt extrudates: How the carrier material can effectively assure rapid or controlled drug release International journal of pharmaceutics, 2017
