Browse studies, page 704

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• High prevalence of erectile dysfunction in male patients with acute stroke was associated with age but not to modifiable cardiovascular risk factors BMJ neurology open, 2024
• The nitric oxide-soluble guanylate cyclase-cGMP pathway in pulmonary hypertension: from PDE5 to soluble guanylate cyclase European respiratory review : an official journal of the European Respiratory Society, 2024
• Winning With Four: Hemodynamic and Symptomatic Improvement of Pulmonary Arterial Hypertension With Contemporary Quadruple Therapy JACC. Case reports, 2025
• Safety, tolerability, and efficacy of an in-class combination therapy switch from bosentan plus sildenafil to ambrisentan plus tadalafil in children with pulmonary arterial hypertension Pulmonary circulation, 2024
• Use of soluble guanylyl cyclase stimulators in heart failure therapy-a mode of action perspective ESC heart failure, 2026
• Phenotypic Clustering of Idiopathic Pulmonary Arterial Hypertension: Insights Into Pulmonary Vascular and Cardiometabolic Co-Morbidity Trajectories Pulmonary circulation, 2026
• Does Characterization of Phenotypic Heterogeneity Provide Mechanistic Insights or Influence the Response to Treatment? Experience in Positive and Neutral Trials in Patients With Heart Failure and a Preserved Ejection Fraction Circulation, 2026
• Early Addition of Selexipag to Double Therapy for Pulmonary Arterial Hypertension JAMA network open, 2024
• Pulmonary Hypertension Associated with Interstitial Lung Disease (PH-ILD): Back to the Future Advances in therapy, 2025
• Non-Invasive Assessment of Endothelial Dysfunction and Arterial Stiffness in Fontan Circulation European journal of clinical investigation, 2026
• The NO Pathway as a Target in Patients with Stable and Advanced Heart Failure: An Additional Arrow in Our Quiver! Biomolecules, 2025
• Stable Longitudinal Quality of Life in the SERVE Trial Among Adults With Transposition of the Great Arteries and a Systemic Right Ventricle CJC pediatric and congenital heart disease, 2025
• Addressing unmet needs for patients with erectile dysfunction: a narrative review of topical therapies Sexual medicine, 2025
• Influence of Patient Characteristics on the Effectiveness of Inhaled Nitric Oxide Therapy for Pulmonary Hypertension Following Cardiac Surgery: A Post-marketing Surveillance in Japan Cureus, 2025
• Pulmonary hypertension associated with nonparenchymal restrictive lung diseases European respiratory review : an official journal of the European Respiratory Society, 2026
• Clinical research on pulmonary hypertension from a 2025 perspective: a narrative review Journal of thoracic disease, 2026
• ShenRongGuBenHuanShao Pill Ameliorates Hydrocortisone-Induced Erectile Dysfunction: Insights from Integrated Multi-Omics Analysis Pharmaceuticals (Basel, Switzerland), 2026
• Neutrophil-to-Lymphocyte Ratio as a Prognostic Factor of Survival Outcomes in Head and Neck Squamous Cell Carcinoma Receiving Neoadjuvant Immunotherapy Cancer medicine, 2026
• The Potential Therapeutic Effects of Tadalafil on the Endothelium in a Subarachnoid Hemorrhage Animal Model: Insights from Immunohistochemical Staining Current issues in molecular biology, 2024
• Updates on Pulmonary Hypertension The open respiratory medicine journal, 2025
• Comparing the efficacy of tadalafil and tamsulosin for managing erectile dysfunction and lower urinary tract symptoms in prostate brachytherapy patients: a prospective study Prostate international, 2024
• Initial Body Weight as an Important Factor for Improving the Reliability and Translational Relevance of the Preclinical Monocrotaline-Induced Rat Pulmonary Hypertension Model International journal of molecular sciences, 2025
• Pulmonary Arterial Hypertension and Left Heart Disease Phenotype: A Challenging Crossroad Cardiology research, 2025
• The impact of PDE5 inhibitors on cardiovascular outcomes Global cardiology science & practice, 2025
• Global stagnation and misaligned priorities in BPH drug development: a 25-year landscape analysis of clinical trial registries npj aging, 2026
• Interaction of sublingual glyceryl tri-nitrate administration on single muscle contraction-induced hyperemia: potential insight into the role of the skeletal muscle pump Frontiers in physiology, 2026
• Antifibrotic therapy for Lower Urinary Tract Symptoms secondary to Benign Prostatic Hyperplasia Prostate cancer and prostatic diseases, 2026
• Association between upper airway obstruction and pulmonary hypertension in children with Down syndrome Current opinion in pulmonary medicine, 2026
• Efficacy and Safety of Mirabegron in Males with Overactive Bladder and Lower Urinary Tract Symptoms: Analysis from an Integrated Database European urology open science, 2025
• Prevalence, pathogenesis, and clinical impact of pulmonary hypertension associated with chronic obstructive pulmonary disease Frontiers in cardiovascular medicine, 2026
• Arduous management in treatment of elderly patient with pulmonary arterial hypertension and cardiopulmonary comorbidities Respiratory medicine case reports, 2025
• Upfront triple combination therapy with selexipag: insights from a real world cohort in Chinese patients with pulmonary arterial hypertension Frontiers in cardiovascular medicine, 2026
• Pericardial Effusion and Prostacyclin Analog Toxicity After Initiation of Sotatercept Pulmonary circulation, 2025
• Penile Rehabilitation After Surgery for Prostate Cancer: An Umbrella Review on Traditional Approaches and Novel Perspectives Journal of clinical medicine, 2026
• Marked clinical and haemodynamic improvement with sotatercept in severe refractory pulmonary arterial hypertension associated with corrected complex congenital heart disease Respiratory medicine case reports, 2026
• The Therapeutic Efficacy of Drugs Targeting the NO-sGC-cGMP Pathway in Treatment of Patients With Chronic Thromboembolic Pulmonary Hypertension: A Systematic Review Pulmonary circulation, 2026
• Proof-of-concept study: APOE4 brain endothelial cells as a phenotypic compound screen Alzheimer's research & therapy, 2026
• Priapism as an Initial Presentation of Sickle Cell Disease: A Case Report Cureus, 2026
• Exploring Integrin α5β1 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension: Insights From Comprehensive Multicenter Preclinical Studies Circulation, 2025
• Update on pulmonary hypertension Respiratory research, 2026
• Pharmacologically increasing cGMP improves proteostasis and reduces neuropathy in mouse models of CMT1 Cellular and molecular life sciences : CMLS, 2024
• Selection of Endothelin Receptor Antagonists in the Treatment of Pulmonary Arterial Hypertension: A Comprehensive Narrative Review Advances in therapy, 2026
• Exploring the therapeutic landscape of pulmonary hypertension associated with interstitial lung disease, with a focus on idiopathic pulmonary fibrosis: a narrative review Frontiers in pharmacology, 2026
• A Comprehensive Review of the Clinical Evidence on the Efficacy, Effectiveness, and Safety of Silodosin for the Treatment of Benign Prostatic Hyperplasia Cureus, 2025
• Impact of cardiovascular risk factors and related comorbid conditions and medical therapy reported at baseline on the treatment response to tadalafil 5 mg once-daily in men with lower urinary tract symptoms associated with benign prostatic hyperplasia: an integrated analysis of four randomised, double-blind, placebo-controlled, clinical trials International journal of clinical practice, 2015
• Changes in peak urinary flow and voiding efficiency in men with signs and symptoms of benign prostatic hyperplasia during once daily tadalafil treatment BJU international, 2010
• Determining the earliest time within 30 minutes to erectogenic effect after tadalafil 10 and 20 mg: a multicenter, randomized, double-blind, placebo-controlled, at-home study The journal of sexual medicine, 2004
• Effects of tadalafil on nighttime voiding (nocturia) in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: a post hoc analysis of pooled data from four randomized, placebo-controlled clinical studies World journal of urology, 2014
• The role of initial success rates and other factors in determining reliability of outcomes of phosphodiesterase inhibitor therapy for erectile dysfunction: a pooled analysis of 17 placebo-controlled trials of tadalafil for use as needed The journal of sexual medicine, 2013
• The efficacy of tadalafil in improving sexual satisfaction and overall satisfaction in men with mild, moderate, and severe erectile dysfunction: a retrospective pooled analysis of data from randomized, placebo-controlled clinical trials Current medical research and opinion, 2005
• Macitentan and phosphodiesterase-5 inhibitor alone or in combination in newly diagnosed pulmonary arterial hypertension: a pooled analysis JHLT open, 2026
• The influence of age on treatment outcomes in men with erectile dysfunction treated with two regimens of tadalafil: results of the SURE study BJU international, 2007
• Factors associated with preference for sildenafil citrate and tadalafil for treating erectile dysfunction in men naïve to phosphodiesterase 5 inhibitor therapy: post hoc analysis of data from a multicentre, randomized, open-label, crossover study BJU international, 2007
• Early improvement of storage or voiding symptoms by tadalafil predicts treatment outcomes in patients with lower urinary tract symptoms from benign prostatic hyperplasia International journal of urology : official journal of the Japanese Urological Association, 2018
• Tolerance to the therapeutic effect of tadalafil does not occur during 6 months of treatment: A randomized, double-blind, placebo-controlled study in men with erectile dysfunction The journal of sexual medicine, 2006
• Effects of dose and age on adverse events associated with tadalafil in the treatment of pulmonary arterial hypertension Pulmonary circulation, 2014
• Onset of efficacy of tadalafil once daily in men with erectile dysfunction: a randomized, double-blind, placebo controlled trial The Journal of urology, 2011
• Tadalafil in the management of lower urinary tract symptoms: a review of the literature and current practices in Russia Central European journal of urology, 2014
• Efficacy of tadalafil in men with erectile dysfunction naïve to phosphodiesterase 5 inhibitor therapy compared with prior responders to sildenafil citrate The journal of sexual medicine, 2006
• Persistent Sexual Dysfunction with Finasteride 1 mg Taken for Hair Loss Pharmacotherapy, 2016
• Latest treatment for lower urinary tract dysfunction: therapeutic agents and mechanism of action International journal of urology : official journal of the Japanese Urological Association, 2013
• (O-30) BZ371A: a first-in-class topical peptide for erectile dysfunction post-prostatectomy – clinical research protocol implementation Journal of Sexual Medicine, 2026
• Kids Mod PAH trial: A multicenter trial comparing mono‐ versus duo‐therapy for initial treatment of pediatric pulmonary hypertension Pulmonary Circulation, 2023
• Clinical utility of tadalafil in the treatment of pulmonary arterial hypertension: an evidence-based review Core Evidence, 2015
• Initial combination therapy with ambrisentan and tadalafil in connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH): subgroup analysis from the AMBITION trial Annals of the Rheumatic Diseases, 2015
• Initial combination therapy with ambrisentan + tadalafil on pulmonary arterial hypertension‒related hospitalization in the AMBITION trial The Journal of Heart and Lung Transplantation, 2019
• Tadalafil 5 mg Alone or in Combination with Tamsulosin 0.4 mg for the Management of Men with Lower Urinary Tract Symptoms and Erectile Dysfunction: Results of a Prospective Observational Trial Journal of Clinical Medicine, 2019
• Safety Evaluation of Tadalafil Treatment for Fetuses with Early-Onset Growth Restriction (TADAFER): Results from the Phase II Trial Journal of Clinical Medicine, 2019
• Monotherapy with tadalafil or tamsulosin similarly improved lower urinary tract symptoms suggestive of benign prostatic hyperplasia in an international, randomised, parallel, placebo-controlled clinical trial European Urology, 2012
• Efficacy Comparison for a Schizophrenia and a Dysuria Drug Among East Asian Populations: A Retrospective Analysis Using Multi-regional Clinical Trial Data Therapeutic Innovation and Regulatory Science, 2021
• (260) Combination Tadalafil and Tamsulosin Therapy Versus Monotherapy for Lower Urinary Tract Symptoms and Erectile Dysfunction: A Randomized Trial Journal of Sexual Medicine, 2026
• Tadalafil for Treatment of Fetal Growth Restriction: A Review of Experimental and Clinical Studies Biomedicines, 2024
• PDE5 inhibition alleviates functional muscle ischemia in boys with Duchenne muscular dystrophy Neurology, 2014
• First in-human modified atrial septostomy combining radiofrequency ablation and balloon dilation Heart (British Cardiac Society), 2022
• Tadalafil combined with behavior therapy for semen collection from infertile males in whom masturbation fails Zhonghua nan ke xue = National journal of andrology, 2013
• Tadalafil 5 mg daily treatment for type 1 diabetic premenopausal women affected by sexual genital arousal disorder The journal of sexual medicine, 2012
• Clinical efficacy of daily low-dose tadalafil on erectile dysfunction-no sexual life Zhonghua nan ke xue = National journal of andrology, 2013
• Low-dose tadalafil for erectile dysfunction following pelvic fracture-induced urethral injury: clinical observation of 42 cases Zhonghua nan ke xue = National journal of andrology, 2013
• Sexual potency preservation and quality of life after prostate brachytherapy and low-dose tadalafil Brachytherapy, 2015
• Efficacy and safety of tetramethylpyrazine phosphate on pulmonary hypertension: study protocol for a randomized controlled study Trials, 2019
• Effect of surgical approach on erectile function recovery following bilateral nerve-sparing radical prostatectomy: an evaluation utilising data from a randomised, double-blind, double-dummy multicentre trial of tadalafil vs placebo BJU international, 2015
• Rationale and study design of RESPITE: An open-label, phase 3b study of riociguat in patients with pulmonary arterial hypertension who demonstrate an insufficient response to treatment with phosphodiesterase-5 inhibitors Respiratory medicine, 2017
• A pilot study to evaluate the safety and efficacy of treprostinil in the treatment of calcinosis in systemic sclerosis Rheumatology (Oxford, England), 2022
• Treatment with rilpivirine does not alter plasma concentrations of the CYP3A substrates tadalafil and midazolam in humans The Journal of antimicrobial chemotherapy, 2016
• Assessment of CYP-Mediated Drug Interactions for Evocalcet, a New Calcimimetic Agent, Based on In Vitro Investigations and a Cocktail Study in Humans Clinical and translational science, 2019
• Effects of phosphodiesterase-5 inhibitor on ischemic kidney injury during nephron sparing surgery: quantitative assessment by NGAL and KIM-1 World journal of urology, 2015
• Effect of rilpivirine on the pharmacokinetics of methadone in HIV-Infected Chinese patients Expert review of clinical pharmacology, 2019
• An analysis of treatment preferences and sexual quality of life outcomes in female partners of Chinese men with erectile dysfunction Asian journal of andrology, 2016
• Effects of tadalafil treatment combined with physical activity in patients with low onset hypogonadism: results from a not-randomized single arm phase 2 study The aging male : the official journal of the International Society for the Study of the Aging Male, 2016
• Chitosan membranes applied on the prostatic neurovascular bundles after nerve-sparing robot-assisted radical prostatectomy: a phase II study BJU international, 2018
• Serenoa repens + selenium + lycopene vs tadalafil 5 mg for the treatment of lower urinary tract symptoms secondary to benign prostatic obstruction: a Phase IV, non-inferiority, open-label, clinical study (SPRITE study) BJU international, 2018
• A 4-week comparison of capillaroscopy changes, healing effect, and cost-effectiveness of botulinum toxin-A vs prostaglandin analog infusion in refractory digital ulcers in systemic sclerosis Clinical rheumatology, 2022
• Effect of Tadalafil on Myocardial and Endothelial Function and Exercise Performance After Modified Fontan Operation Pediatric cardiology, 2016
• Effects of taking tadalafil 5 mg once daily on erectile function and total testosterone levels in patients with metabolic syndrome Andrologia, 2017
• Antivirals for adult patients hospitalized with SARS-CoV-2 infection: A randomized, Phase II/III, multicenter, placebo-controlled, adaptive study, with multiple arms and stages. COALITION COVID-19 BRAZIL IX - REVOLUTIOn: protocol and statistical analysis plan Revista Brasileira de terapia intensiva, 2022
• Evaluation of arterial stiffness and cardiac function in patients with vascular erectile dysfunction: acute effects of phosphodiesterase-5 inhibitor tadalafil International journal of impotence research, 2017
• Effects of tadalafil on storage and voiding function in patients with male lower urinary tract symptoms suggestive of benign prostatic hyperplasia: A urodynamic-based study International journal of urology : official journal of the Japanese Urological Association, 2018
• Evaluation of the long-term safety and effectiveness of tadalafil once daily in Chinese men with erectile dysfunction: interim results of a multicenter, randomized, open-label trial Asian journal of andrology, 2018
• Oral treprostinil improves pulmonary vascular compliance in pulmonary arterial hypertension Respiratory medicine, 2022
• TADAFER II: Tadalafil treatment for fetal growth restriction - a study protocol for a multicenter randomised controlled phase II trial BMJ open, 2018