Browse studies, page 709

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• Effect of Tadalafil on Insulin Secretion and Insulin Sensitivity in Obese Men ClinicalTrials.gov · COMPLETED, 2015
• A Phase 2 Study of the Safety, Efficacy, and Immune Response of CRS-207, Pembrolizumab, Ipilimumab, and Tadalafil in Patients With Previously Treated Metastatic Pancreatic Adenocarcinoma ClinicalTrials.gov · COMPLETED, 2025
• A Randomized, Open-label, Multiple Dosing, 2-way Crossover Study to Evaluate the Pharmacokinetic Effect of Tamsulosin on Tadalafil in Healthy Male Volunteers ClinicalTrials.gov · COMPLETED, 2014
• Tadalafil Combined With Low-Energy Pulsed Ultrasound (LIPUS) for the Treatment of Erectile Dysfunction: A Prospective, Randomized Controlled Clinical Trial ClinicalTrials.gov · COMPLETED, 2025
• A Single-center, Open-label, Single-dose, Randomized, 2-way Crossover Phase 1 Study in Healthy Adult Participants to Assess the Relative Oral Bioavailability of the Combination of Macitentan/Tadalafil (10 mg/20 mg) Administered a Fixed-dose Combination Formulation Compared to the Reference Free Combination of 10 mg Macitentan (Opsumit®) and 20 mg Tadalafil (Adcirca®) ClinicalTrials.gov · COMPLETED, 2021
• A Randomized Controlled Trial of the Effects of Tadalafil and Dexamethasone Versus Placebo on Pulmonary Edema Formation and Cerebral Blood Flow Autoregulation in High Altitude Newcomers With a Previous History of High Altitude Pulmonary Edema ClinicalTrials.gov · COMPLETED, 2003
• A Randomized, Open-Label, Crossover, Multicenter, Single Dose Comparator Study Evaluating Onset Of Penile Rigidity In Men With Erectile Dysfunction Who Are Treated With Viagra (Sildenafil Citrate) And Cialis (Tadalafil) ClinicalTrials.gov · COMPLETED, 2003
• Effect of Tadalafil on Exercise Capacity in Pediatric Fontan Patients ClinicalTrials.gov · COMPLETED, 2014
• Comparison of Mirabegron ,Tamsulosin and Solifenacinin Relieving Double -J Stent Related Symptoms : Approspective Randmized Placebo Controlledtrial ClinicalTrials.gov · COMPLETED, 2023
• Prospective, Multicenter, Open-label Study Evaluating the Effects of First-line Oral Combination Therapy of Macitentan and Tadalafil in Patients With Newly Diagnosed Pulmonary Arterial Hypertension (OPTIMA) ClinicalTrials.gov · TERMINATED, 2018
• A Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of Tadalafil Administered "On Demand" to Patients With Erectile Dysfunction ClinicalTrials.gov · COMPLETED, 2004
• A Randomized Controlled Double-Blind Trial for Prevention of Recurrent Ischemic Priapism in Men With Sickle Cell Disease: A Pilot Study ClinicalTrials.gov · COMPLETED, 2023
• A Randomized, Double-Blind, Parallel-Design, Placebo-Controlled Study to Evaluate the Effects of 5 mg Tadalafil (IC351, LY450190) and 50 mg Sildenafil Administered Once Daily for 6 Months on Visual Function in Healthy Subjects or Subjects With Mild Erectile Dysfunction ClinicalTrials.gov · COMPLETED, 2006
• Define in Preclinical Diastolic Dysfunction (PDD) With Renal Dysfunction, the Cardiorenal and Humoral Actions of Chronic Type V Phosphodiesterase (PDEV) Inhibition ClinicalTrials.gov · COMPLETED, 2019
• A Randomized, Double-Blind, Parallel Group, Placebo-Controlled Study Evaluating the Efficacy and Safety of Tadalafil (5mg and 20mg) Administered Once Daily to Subjects With Mild to Moderate Hypertension ClinicalTrials.gov · COMPLETED, 2006
• A Phase 1 Study to Demonstrate the Relative Bioavailability of Fixed Dose Combinations of Ambrisentan and Tadalafil in Healthy Subjects ClinicalTrials.gov · COMPLETED, 2017
• Non Ablative Erbium:YAG Laser Transurethral Treatment for Chronic Prostatitis/Chronic Pelvic Pain Syndrome in Younger Patients: a Prospective Comparative Study ClinicalTrials.gov · COMPLETED, 2018
• A Randomised, Double-Blind, Placebo-Controlled Study to Evaluate the Effect on Unassisted Erectile Function of the Early Use of Tadalafil 5 mg Once a Day and Tadalafil 20 mg On Demand Treatment for 9 Months in Subjects Undergoing Bilateral Nerve-Sparing Radical Prostatectomy ClinicalTrials.gov · COMPLETED, 2012
• Switching From Sildenafil Citrate to Tadalafil in Treatment of Erectile Dysfunction: Assessment of Treatment Preference ClinicalTrials.gov · COMPLETED, 2005
• A Post-Marketing Clinical Study of LY450190 (Combined With Alpha1 Blocker Treatment) ClinicalTrials.gov · COMPLETED, 2016
• Inhibitory effects of sildenafil and tadalafil on inflammation, oxidative stress and nitrosative stress in animal model of bronchial asthma Pharmacological Reports, 2019
• Tadalafil treatment in mice for preeclampsia with fetal growth restriction has neuro-benefic effects in offspring through modulating prenatal hypoxic conditions Scientific Reports, 2019
• Efficacy and safety of low-intensity shockwave therapy plus tadalafil 5 mg once daily in men with type 2 diabetes mellitus and erectile dysfunction: a matched-pair comparison study Asian Journal of Andrology, 2019
• Protective effects of tadalafil on prostatic hyperplasia in spontaneously hypertensive rats European Journal of Pharmacology, 2020
• The phosphodiesterase 5 inhibitor tadalafil has renoprotective effects in a rat model of chronic kidney disease Physiological Reports, 2020
• Effects of macitentan and tadalafil monotherapy or their combination on the right ventricle and plasma metabolites in pulmonary hypertensive rats Pulmonary Circulation, 2020
• Development of an analytical method based on citric acid coated magnetite nanoparticles assisted dispersive magnetic solid-phase extraction for the enrichment and extraction of sildenafil, tadalafil, vardenafil and avanafil in human plasma and urine prior to determination by LC-MS/MS Microchemical journal (Print), 2019
• Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods Pharmaceutics, 2019
• Sildenafil and tadalafil reduce the risk of contrast-induced nephropathy by modulating the oxidant/antioxidant balance in a murine model Food and Chemical Toxicology, 2019
• Enhancement of the apparent solubility and bioavailability of Tadalafil nanoparticles via antisolvent precipitation European Journal of Pharmaceutical Sciences, 2019
• A novel drug–drug coamorphous system without molecular interactions: improve the physicochemical properties of tadalafil and repaglinide RSC Advances, 2019
• Smart spectrophotometric assessment of tamsulosin hydrochloride and tadalafil in their new pharmaceutical formulation for treatment of benign prostatic hyperplasia and erectile dysfunction Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy, 2019
• Tadalafil restores long-term memory and synaptic plasticity in mice with hepatic encephalopathy Toxicology and Applied Pharmacology, 2019
• Tadalafil treatment improves cardiac, renal and lower urinary tract dysfunctions in rats with heart failure Life Science, 2021
• A Novel Analytical Method for Simultaneous Quantification of Silodosin and Tadalafil by RP-HPLC Journal of Pharmaceutical Research International, 2021
• Simultaneous determination of citalopram and tadalafil by the second derivative synchronous fluorescence method in biological fluids; application of Box-Behnken optimization design Luminescence (Chichester, England Print), 2020
• Evaluation of combined therapeutic effects of hydrogen sulfide donor sodium hydrogen sulfide and phosphodiesterase type‐5 inhibitor tadalafil on erectile dysfunction in a partially bladder outlet obstructed rat model Neurourology and Urodynamics, 2020
• Effect of supersaturation on absorption of indomethacin and tadalafil in a single pass intestinal perfusion rat model, in the absence and presence of a precipitation inhibitor European journal of pharmaceutics and biopharmaceutics, 2020
• Chronic inhibition of phosphodiesterase 5 with tadalafil affords cardioprotection in a mouse model of metabolic syndrome: Role of Nitric Oxide Molecular and Cellular Biochemistry, 2020
• The Daily Therapy With L-Arginine 2,500 mg and Tadalafil 5 mg in Combination and in Monotherapy for the Treatment of Erectile Dysfunction: A Prospective, Randomized Multicentre Study Sexual Medicine, 2020
• A novel multifaceted approach for wound healing: optimization and in vivo evaluation of spray dried tadalafil loaded pro-nanoliposomal powder International journal of pharmaceutics, 2020
• Tadalafil ameliorates memory deficits, oxidative stress, endothelial dysfunction and neuropathological changes in rat model of hyperhomocysteinemia induced vascular dementia International Journal of Neuroscience, 2020
• D-optimal design as a useful tool response surface methodology for the optimization of signals from synchronous fluorescence prior to simultaneous determination of avanafil and tadalafil Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy, 2020
• Protective and therapeutic effects of sildenafil and tadalafil on aflatoxin B1-induced hepatocellular carcinoma Molecular and Cellular Biochemistry, 2020
• Tadalafil-Loaded Limonene-Based Orodispersible Tablets: Formulation, in vitro Characterization and in vivo Appraisal of Gastroprotective Activity International Journal of Nanomedicine, 2020
• Tadalafil may improve cerebral perfusion in small-vessel occlusion stroke—a pilot study Brain Communications, 2020
• Tamsulosin and placebo vs tamsulosin and tadalafil in male lower urinary tract symptoms: a double-blinded, randomised controlled trial BJU International, 2020
• Whether Adding Vitamin D to Tadalafil 5 mg Treatment Is Useful in Patients with Erectile Dysfunction and Vitamin D Deficiency? Urologia internationalis, 2021
• Surgical Suture Assembled with Tadalafil/Polycaprolactone Drug-Delivery for Vascular Stimulation Around Wound: Validated in a Preclinical Model Biointerface Research in Applied Chemistry, 2020
• Falsified tadalafil tablets distributed in Japan via the internet Forensic Science International, 2020
• Repurposing erectile dysfunction drugs tadalafil and vardenafil to increase bone mass Proceedings of the National Academy of Sciences of the United States of America, 2020
• Aliskiren, tadalafil, and cinnamaldehyde alleviate joint destruction biomarkers; MMP-3 and RANKL; in complete Freund's adjuvant arthritis model: Downregulation of IL-6/JAK2/STAT3 signaling pathway Saudi Pharmaceutical Journal, 2020
• Hemodynamics and risk assessment 2 years after the initiation of upfront ambrisentan‒tadalafil in pulmonary arterial hypertension The Journal of Heart and Lung Transplantation, 2020
• Tadalafil enhances the therapeutic efficacy of BET inhibitors in hepatocellular carcinoma through activating hippo pathway Biochimica et Biophysica Acta - Molecular Basis of Disease, 2021
• Digital Real-world Data Suggest Patient Preference for Tadalafil over Sildenafil in Patients with Erectile Dysfunction European Urology Focus, 2021
• Tadalafil ameliorates bladder overactivity by restoring insulin-activated detrusor relaxation via the bladder mucosal IRS/PI3K/AKT/eNOS pathway in fructose-fed rats Scientific Reports, 2021
• Implementing Analytical Quality by Design (AQbD) Approach for Simultaneous Estimation of Tadalafil and Macitentan by RP-HPLC Method Analytical Chemistry Letters, 2021
• Stability assessment of tamsulosin and tadalafil co-formulated in capsules by two validated chromatographic methods Journal of Separation Science, 2020
• Improved molecular softness of tadalafil hapten enhancing antibody performance in immunoassay: Evidence from computational chemistry Journal of Food Science, 2022
• Novel HPTLC densitometric methods for determination of tamsulosin HCl and tadalafil in their newly formulated dosage form; Comparative study and green profile assessment Biomedical chromotography, 2020
• Initial combination therapy of ambrisentan and tadalafil in connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH) in the modified intention-to-treat population of the AMBITION study: post hoc analysis Annals of the Rheumatic Diseases, 2020
• Initial combination therapy of macitentan and tadalafil in pulmonary arterial hypertension European Respiratory Journal, 2020
• Integration of Transcriptomics and Metabolomics Reveals the Antitumor Mechanism Underlying Tadalafil in Colorectal Cancer Frontiers in Pharmacology, 2022
• Analysis of integrated clinical safety data of tadalafil in patients receiving concomitant antihypertensive medications The Journal of Clinical Hypertension, 2022
• Is tadalafil associated with decreased risk of major adverse cardiac events or venous thromboembolism in men with lower urinary tract symptoms? World journal of urology, 2022
• Cytochrome P450 3A4-mediated pharmacokinetic interaction study between Tadalafil and Canagliflozin using High Performance Thin Layer Chromatography Journal of Separation Science, 2022
• Prospective comparison of tadalafil 5 mg alone, silodosin 8 mg alone, and the combination of both in treatment of lower urinary tract symptoms related to benign prostatic hyperplasia World journal of urology, 2022
• Role of ADMA/DDAH-1 and iNOS/eNOS signaling in the gastroprotective effect of tadalafil against indomethacin-induced gastric injury Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022
• Tadalafil Enhances Immune Signatures in Response to Neoadjuvant Nivolumab in Resectable Head and Neck Squamous Cell Carcinoma Clinical Cancer Research, 2021
• The Wound Healing Effect of Nanoclay, Collagen, and Tadalafil in Diabetic Rats: An In Vivo Study Advances in Materials Science and Engineering, 2022
• Effects of furosemide and tadalafil in both conventional and nanoforms against adenine-induced chronic renal failure in rats European Journal of Medical Research, 2022
• Supramolecular Tadalafil Nanovaccine for Cancer Immunotherapy by Alleviating Myeloid-Derived Suppressor Cells and Heightening Immunogenicity Small Methods, 2021
• Initial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial Hypertension New England Journal of Medicine, 2015
• The PASTIS trial: Testing tadalafil for possible use in vascular cognitive impairment Alzheimer's & Dementia, 2022
• Effects of tadalafil on sexual behavior of male rats induced by chronic unpredictable mild stress Sexual Medicine, 2023
• Synchronous fluorescence as a green and selective method for the simultaneous determination of finasteride and tadalafil in dosage form and spiked human plasma Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy, 2023
• Proniosomal Gel-Loaded Phosphodiesterase Inhibitors (Sildenafil, Vardenafil, and Tadalafil): Prospects for Topical Penile Therapy of Tadalafil for Treatment of Erectile Dysfunction Gels, 2023
• Application of Box-Behnken Design in the Preparation, Optimization, and In-Vivo Pharmacokinetic Evaluation of Oral Tadalafil-Loaded Niosomal Film Pharmaceutics, 2023
• Neuronal nitric oxide synthase activation by tadalafil protects neurological impairments in a zebrafish larva model of hyperammonemia Life Science, 2024
• Phosphodiesterase type 5 inhibitor tadalafil reduces prostatic fibrosis via MiR-3126-3p/FGF9 axis in benign prostatic hyperplasia Biology Direct, 2024
• Environmentally benign first derivative synchronous spectrofluorimetry for the analysis of two binary mixtures containing duloxetine with avanafil or tadalafil in spiked plasma samples Luminescence (Chichester, England Print), 2024
• High-Altitude Pulmonary Edema Management in a Special Operator Journal of special operations medicine : a peer reviewed journal for SOF medical professionals, 2026
• Integrating machine learning with lateral flow immunoassay for ultrafast and sensitive tadalafil detection Food chemistry, 2026
• Chlorpromazine-Tadalafil Interaction Leading to Refractory Ischemic Priapism and Penile Prosthesis Implantation 2025
• Cognitive outcomes after tadalafil treatment in patients with cerebral small vessel disease: ETLAS-2 sub-study Cerebral circulation - cognition and behavior, 2025
• Pulmonary Hypertension Workup Unraveling a Rare Anomaly in Turner Syndrome Cureus, 2026
• Drug-Drug Coamorphous System of Tadalafil and Finasteride for Enhanced Pharmaceutical Performance Molecular pharmaceutics, 2026
• Synthesis and Pharmacological Evaluation of 6,7-Dihydro‑3H‑Oxazolo[3,4‑a]Pyrazine-5,8-Dione Compounds as Inhibitors of Phosphodiesterases 4 and 5 ACS medicinal chemistry letters, 2026
• Vardenafil in the multidisciplinary management of erectile dysfunction: a narrative review on multidimensional outcomes and clinical integration World journal of urology, 2026
• Modulating phosphodiesterase-5 activity to suppress the immunosuppressive mechanisms of myeloid-derived suppressor cells in breast cancer Breast cancer research : BCR, 2025
• Phosphodiesterase-5 Inhibitor Use Masking a Necrotizing Syphilitic Infection: A Rare Differential Diagnosis of Priapism Case reports in urology, 2026
• Eisenmenger Syndrome Hidden by Unrepaired Patent Ductus Arteriosus: Diagnosis After Delivery JACC. Case reports, 2026
• Phytotherapies and Complementary Therapies for Erectile Dysfunction: A Focused Secondary Synthesis and Critical Clinical Interpretation of the AFU/SFMS Evidence Base The French journal of urology, 2026
• A Single-Centre Clinical Audit of Erectile Dysfunction Assessment and Management in UK General Practice Against National Guidelines Cureus, 2026
• Analytical strategies for identifying PDE5 inhibitors in damiana (Turnera diffusa) products Journal of chromatography. A, 2026
• Radiodensity as a predictor: can penile and splenic Hounsfield units forecast clinical response to daily tadalafil? Basic and clinical andrology, 2026
• An In Silico and In Vitro Approach Identified Potential Trypanothione Synthetase Inhibitors with Trypanocidal Activity Molecules (Basel, Switzerland), 2026
• Enhanced antiproliferative and anti-inflammatory effects of combined metformin, tadalafil, and tamsulosin in a rat model of testosterone-induced benign prostatic hyperplasia Life sciences, 2026
• Effect of Stereochemistry on the Antiplasmodial Activity and Metabolomic Profile of Novel Tadalafil Analogues ACS medicinal chemistry letters, 2026
• Evaluation of vardenafil's metabolic stability in human liver microsomes through ultra-fast UPLC-MS/MS for quantitative analysis, including assessments of greenness, ADME properties, DEREK alerts, and metabolic lability The Analyst, 2026