Browse studies, page 824

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• Metformin: Potential analgesic? Pain medicine (Malden, Mass.), 2015
• The preventive effect of metformin on progression of benign prostate hyperplasia: A nationwide population-based cohort study in Korea PLoS ONE, 2019
• Effectiveness and safety of vildagliptin and vildagliptin add-on to metformin in real-world settings in Egypt - results from the GUARD study Current medical research and opinion, 2017
• Non-positive Airway Pressure Therapies for Obstructive Sleep Apnoea and Central Sleep Apnoea Cardiac failure review, 2026
• γδ T-cell interferon-γ production reflects metabolic improvement during SGLT2 inhibitor-based therapy in type 2 diabetes Frontiers in endocrinology, 2026
• Prognostic implications of glucose-lowering treatment in patients with acute myocardial infarction and diabetes: experiences from an extended follow-up of the Diabetes Mellitus Insulin-Glucose Infusion in Acute Myocardial Infarction (DIGAMI) 2 Study Diabetologia, 2011
• Saxagliptin efficacy and safety in patients with type 2 diabetes mellitus stratified by cardiovascular disease history and cardiovascular risk factors: analysis of 3 clinical trials Postgraduate medicine, 2014
• Impact of fetal growth restriction on pregnancy outcome in women undergoing expectant management for preterm pre-eclampsia Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2023
• Effects of Glimepiride versus Saxagliptin on β-Cell Function and Hypoglycemia: A Post Hoc Analysis in Older Patients with Type 2 Diabetes Inadequately Controlled with Metformin Clinical therapeutics, 2016
• Undiagnosed chronic kidney disease in people with type 2 diabetes in Spain: Prevalence, treatment patterns and associated factors in a multicentre cross-sectional study Primary care diabetes, 2026
• Efficacy and Safety of Finerenone in Type 2 Diabetes: A Pooled Analysis of Trials of Heart Failure and Chronic Kidney Disease Diabetes care, 2025
• Dapagliflozin-induced integrated improvements in left ventricular diastole, endothelial function, and arterial load: a randomized clinical trial Cardiovascular diabetology, 2026
• Comparison of alogliptin and glipizide for composite endpoint of glycated haemoglobin reduction, no hypoglycaemia and no weight gain in type 2 diabetes mellitus Diabetes, obesity & metabolism, 2016
• Efficacy and safety of empagliflozin in combination with other oral hypoglycemic agents in patients with type 2 diabetes mellitus Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion, 2016
• Maternal and fetal insulin levels at birth in women with polycystic ovary syndrome: data from a randomized controlled study on metformin European journal of endocrinology, 2014
• Real-world safety of dapagliflozin plus metformin in patients of type 2 diabetes mellitus in China: Post-hoc analysis of the DONATE study Diabetes research and clinical practice, 2025
• Cardiovascular and renal safety of metformin in patients with diabetes and moderate or severe chronic kidney disease: Observations from the EXSCEL and SAVOR-TIMI 53 cardiovascular outcomes trials Diabetes, obesity & metabolism, 2021
• Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity Aging, 2023
• Effect of metformin on thyroid function tests in patients with subclinical hypothyroidism: an open-label randomised controlled trial Journal of endocrinological investigation, 2019
• Initial combination therapy with metformin plus colesevelam in drug-naïve Hispanic patients with early type 2 diabetes Postgraduate medicine, 2012
• Serum lipids and their association with birth weight in metformin and insulin treated patients with gestational diabetes Diabetes research and clinical practice, 2020
• Growth differentiation factor 15 is not associated with glycemic control in patients with type 2 diabetes mellitus treated with metformin: a post-hoc analysis of AIM study BMC endocrine disorders, 2022
• Do oral antidiabetic medications alter the risk of Parkinson's disease? An updated systematic review and meta-analysis Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2023
• Circulating selenoprotein P levels predict glucose-lowering and insulinotropic effects of metformin, but not alogliptin: A post-hoc analysis Journal of diabetes investigation, 2023
• Optimizing the Interaction of Exercise Volume and Metformin to Induce a Clinically Significant Reduction in Metabolic Syndrome Severity: A Randomised Trial International journal of environmental research and public health, 2020
• Effects of exenatide once weekly plus dapagliflozin, exenatide once weekly, or dapagliflozin, added to metformin monotherapy, on body weight, systolic blood pressure, and triglycerides in patients with type 2 diabetes in the DURATION-8 study Diabetes, obesity & metabolism, 2018
• Cardiovascular safety and efficacy of metformin-SGLT2i versus metformin-sulfonylureas in type 2 diabetes: systematic review and meta-analysis of randomized controlled trials Scientific reports, 2021
• Dihydroartemisinin for the treatment of polycystic ovary syndrome: study protocol for a multi-centre placebo-controlled randomised clinical trial BMJ open, 2026
• Comparison of live birth rates between calorie-restricted diet and metformin prior to ovulation induction therapy in women with polycystic ovary syndrome and overweight/obesity: a protocol for a multicenter, randomized comparative effectiveness trial Frontiers in public health, 2026
• A comparison of the effects of cinnamon, ginger, and metformin consumption on metabolic health, anthropometric indices, and sexual hormone levels in women with poly cystic ovary syndrome: A randomized double-blinded placebo-controlled clinical trial Frontiers in Nutrition, 2022
• Estimating the True MACE Benefits From Tirzepatide in SURPASS-CVOT Using an Imputed Placebo Analysis of REWIND Diabetes care, 2026
• More than Hormones? Metabolic Effects of Twelve-Week Probiotic Supplementation in Women with Polycystic Ovary Syndrome: A Secondary Analysis of a Randomized Double-Blind Placebo-Controlled Study Nutrients, 2026
• Effects of metformin on glucose metabolism and mitochondrial function in patients with obstructive sleep apnea: A pilot randomized trial Physiological reports, 2024
• Tolerability, safety and feasibility of metformin combined with chemoradiotherapy in patients with locally advanced cervical cancer: A phase II, randomized study Acta oncologica (Stockholm, Sweden), 2025
• Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes Cell reports, 2016
• The Pharmacokinetic Interaction Between Metformin and the Natural Product Goldenseal Is Metformin Dose-Dependent: A Three-Arm Crossover Study in Adults With Type 2 Diabetes Clinical and translational science, 2025
• Pharmacokinetic comparison using two tablets of an evogliptin/metformin XR 2.5/500 mg fixed dose combination vs. 1 tablet each of evogliptin 5 mg and metformin XR 1,000 mg . International journal of clinical pharmacology and therapeutics, 2017
• Effects of Low Dose Metformin on Metabolic Traits in Clozapine-Treated Schizophrenia Patients: An Exploratory Twelve-Week Randomized, Double-Blind, Placebo-Controlled Study PloS one, 2016
• Bioequivalence, Food Effect, and Steady-State Assessment of Dapagliflozin/Metformin Extended-release Fixed-dose Combination Tablets Relative to Single-component Dapagliflozin and Metformin Extended-release Tablets in Healthy Subjects Clinical therapeutics, 2015
• Effect of different doses of metformin on serum testosterone and insulin in non-diabetic women with breast cancer: a randomized study Clinical breast cancer, 2012
• A non-linear pharmacokinetic-pharmacodynamic relationship of metformin in healthy volunteers: An open-label, parallel group, randomized clinical study PloS one, 2018
• The influence of telmisartan on metformin pharmacokinetics and pharmacodynamics Journal of pharmacological sciences, 2019
• Pharmacogenetics of Metformin for Medication-Induced Weight Gain in Autism Spectrum Disorder Journal of child and adolescent psychopharmacology, 2019
• Circulating levels of MOTS-c in patients with breast cancer treated with metformin Aging, 2022
• Metformin as an adjunct therapy for the treatment of moderate to severe acne vulgaris: A randomized open-labeled study Dermatologic therapy, 2019
• Efficacy, tolerability, and safety of a novel once-daily extended-release metformin in patients with type 2 diabetes Diabetes care, 2006
• The addition of sitagliptin to ongoing metformin therapy significantly improves glycemic control in Chinese patients with type 2 diabetes Journal of diabetes, 2012
• Effect of metformin and rosiglitazone on lipid metabolism in HIV infected patients receiving protease inhibitor containing HAART. Acta dermatovenerologica Alpina, Pannonica, et Adriatica, 2005
• Modulation of hunger by plasma glucose and metformin The Journal of clinical endocrinology and metabolism, 2003
• Pubertal adiposity after fetal growth restraint: toward a calorie restriction mimetic approach Metabolism: clinical and experimental, 2008
• Metformin versus acarbose therapy in patients with polycystic ovary syndrome (PCOS): a prospective randomised double-blind study Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2010
• Metformin influence on hormone levels at birth, in PCOS mothers and their newborns Human reproduction (Oxford, England), 2010
• A randomized, double-blind, placebo controlled, phase 3 trial to evaluate the efficacy and safety of cetagliptin added to ongoing metformin therapy in patients with uncontrolled type 2 diabetes with metformin monotherapy Diabetes, obesity & metabolism, 2023
• Effects of pioglitazone versus metformin on circulating endothelial microparticles and progenitor cells in patients with newly diagnosed type 2 diabetes--a randomized controlled trial Diabetes, obesity & metabolism, 2011
• Metabolic and haemodynamic effects of metformin in patients with type 2 diabetes mellitus and hypertension Diabetes, obesity & metabolism, 2001
• Troglitazone or metformin in combination with sulfonylureas for patients with type 2 diabetes? The Journal of family practice, 1999
• Metformin or antiandrogen in the treatment of hirsutism in polycystic ovary syndrome The Journal of clinical endocrinology and metabolism, 2003
• Acute metformin administration increases mean power and the early Power phase during a Wingate test in healthy male subjects European journal of sport science, 2022
• Fetal and post-natal outcomes in offspring after intrauterine metformin exposure: A systematic review and meta-analysis of animal experiments Diabetic medicine : a journal of the British Diabetic Association, 2024
• Clinical outcomes with metformin use in diabetic patients with compensated cirrhosis: a systematic review and meta-analysis European journal of gastroenterology & hepatology, 2024
• Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome The Cochrane database of systematic reviews, 2019
• Metformin added to insulin therapy for type 1 diabetes mellitus in adolescents The Cochrane database of systematic reviews, 2009
• Effect of metformin on incidence, recurrence, and mortality in prostate cancer patients: integrating evidence from real-world studies Prostate cancer and prostatic diseases, 2025
• Metformin versus clomiphene citrate for infertility in non-obese women with polycystic ovary syndrome: a systematic review and meta-analysis Human reproduction update, 2013
• Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome The Cochrane database of systematic reviews, 2014
• The effect of a dual combination of noninsulin antidiabetic drugs on lipids: a systematic review and network meta-analysis Current medical research and opinion, 2014
• Screening for Prediabetes and Type 2 Diabetes in Children and Adolescents: Evidence Report and Systematic Review for the US Preventive Services Task Force JAMA, 2022
• Will metformin use lead to a decreased risk of thyroid cancer? A systematic review and meta-analyses European journal of medical research, 2023
• Editor's Choice - Association Between Metformin Prescription and Abdominal Aortic Aneurysm Growth and Clinical Events: a Systematic Review and Meta-Analysis European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2021
• Effect of the combined oral contraceptive pill and/or metformin in the management of polycystic ovary syndrome: A systematic review with meta-analyses Clinical endocrinology, 2019
• Adipokines as a therapeutic target by metformin to improve metabolic function: A systematic review of randomized controlled trials Pharmacological research, 2021
• Metformin has heterogeneous effects on model organism lifespans and is beneficial when started at an early age in Caenorhabditis elegans: A systematic review and meta-analysis Aging cell, 2022
• Anti-Müllerian Hormone levels after metformin treatment in polycystic ovary syndrome: A systematic review and meta-analysis Obesity research & clinical practice, 2023
• Clinical evidence for the prognostic impact of metformin in cancer patients treated with immune checkpoint inhibitors International immunopharmacology, 2024
• Clinical inquiries. What is the role of combination therapy (insulin plus oral medication) in type 2 diabetes? The Journal of family practice, 2006
• The cost-effectiveness of metformin in pre-diabetics: a systematic literature review of health economic evaluations Expert review of pharmacoeconomics & outcomes research, 2020
• Effect of metformin use on the risk and prognosis of ovarian cancer: an updated systematic review and meta-analysis Panminerva medica, 2023
• Metformin Use and Lung Cancer Risk in Diabetic Patients: A Systematic Review and Meta-Analysis Disease markers, 2019
• Effects of orlistat vs. metformin on weight loss-related clinical variables in women with PCOS: systematic review and meta-analysis International journal of clinical practice, 2016
• Monotherapy with Metformin versus Sulfonylureas and Risk of Cancer in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis Journal of diabetes research, 2019
• The effect of metformin on biomarkers associated with breast cancer outcomes: a systematic review, meta-analysis, and dose-response of randomized clinical trials Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2020
• Metformin Use and Risk of All-Cause Mortality and Cardiovascular Events in Patients With Chronic Kidney Disease-A Systematic Review and Meta-Analysis Frontiers in endocrinology, 2020
• Metformin versus insulin in gestational diabetes mellitus: a systematic review Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia, 2024
• Metformin Use and Kidney Cancer Survival Outcomes: A Systematic Review and Meta-Analysis American journal of clinical oncology, 2019
• Metformin versus glyburide in treatment and control of gestational diabetes mellitus: a systematic review with meta-analysis Einstein (Sao Paulo, Brazil), 2022
• Combined regimens of cisplatin and metformin in cancer therapy: A systematic review and meta-analysis Life sciences, 2022
• A systematic review of the uses of metformin in dermatology Clinical and experimental dermatology, 2023
• The Association between Metformin Therapy and Lactic Acidosis Drug safety, 2019
• Etiology and Management of Acute Metabolic Acidosis: An Update Kidney & blood pressure research, 2020
• Effect of metformin on colorectal carcinoma in type 2 diabetes mellitus patients: a Markov model analysis Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery, 2017
• Comparative efficacy and safety of OADs in management of GDM: network meta-analysis of randomized controlled trials The Journal of clinical endocrinology and metabolism, 2015
• Metformin plus a low hypoglycemic risk antidiabetic drug vs. metformin monotherapy for untreated type 2 diabetes mellitus: A meta-analysis of randomized controlled trials Diabetes research and clinical practice, 2022
• Relationships are between metformin use and survival in pancreatic cancer patients concurrent with diabetes: A systematic review and meta-analysis Medicine, 2020
• Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary syndrome The Cochrane database of systematic reviews, 2020
• Is metformin use associated with a reduced risk of oesophageal cancer? A systematic review and meta-analysis Postgraduate medical journal, 2022
• Immune-mediated antitumor effect by type 2 diabetes drug, metformin Proceedings of the National Academy of Sciences, 2015
• A Randomized, Open, Single-dose, Crossover-design, Phase I Study to Evaluate Bioequivalence After Co-administration of ALO 12.5 mg and MET XR 500 mg or Administration of CT-L01 12.5/500 mg in Healthy Volunteers ClinicalTrials.gov · COMPLETED, 2022
• A Phase 1, Open-Label, Fixed-Sequence Study to Evaluate the Effect of Vimseltinib on Organic Cation Transporter 2 (OCT2) Inhibition in Healthy Male Participants ClinicalTrials.gov · COMPLETED, 2026
• Comparative Clinical and Biochemical Study Evaluating the Effectiveness of Metformin Versus Febuxostate on Gouty Obese Non-Diabetic Patients ClinicalTrials.gov · COMPLETED, 2025
• A Phase I, First In Human, Double Blind, Placebo Controlled, Single Ascending Dose Study To Evaluate The Safety, Tolerability, Pharmacokinetics, Pharmacodynamics And Interaction Effect With Metformin Following A Single Oral Dose Of DA-1241 In Healthy Male Subjects ClinicalTrials.gov · COMPLETED, 2017