Browse studies, page 825

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• Phenotypic and Genetic Correlates of Diabetes (Non-Type 1) in Young Non-Obese Asian Indians in North India and A Study to Evaluate the Efficacy of Sitagliptin (DPP-4 Inhibitor) in a Sub-group of the Study Population ClinicalTrials.gov · COMPLETED, 2015
• The Potential for Metformin to Improve Tumor Oxygenation in Locally Advanced Cervix Cancer: A Phase II Randomized Trial ClinicalTrials.gov · COMPLETED, 2021
• Is the Co-administration of Metformine and CC as Compared to Placebo and CC Superior to Induce Ovulation in PCOS Patients With a Confirmed insulin-resistant-a Double Blind Randomized Clinical Trial ClinicalTrials.gov · TERMINATED, 2022
• A Randomized, Open-label, Parallel, Treat to Target Study Comparing the Efficacy and Safety of HR17031 With Insulin Glargine in Chines Subjects With Type 2 Diabetes Inadequately Controlled With Metformin in Combination With or Without Another Oral Antidiabetic Drug (OAD) ClinicalTrials.gov · COMPLETED, 2025
• Effect of Metformin and Combination of Olive Oil Plus Nutritional Supplements on Inflammatory Markers IL-6 and IL-8 in PCOS. ClinicalTrials.gov · COMPLETED, 2024
• Combined Letrozole-metformin-pioglitazone Versus Combined Clomiphene Citrate-metformin-pioglitazone in Clomiphene Citrate-resistant Women With Polycystic Ovary Syndrome ClinicalTrials.gov · COMPLETED, 2014
• The Effects of Treatment With Oral Contraceptive Pill Containing Ethinyl Estradiol-Cyproterone Acetate and Metformin on Clinical, Hormonal, Metabolic and Ultrasonographic Characteristics in Polycystic Ovarian Syndrome ClinicalTrials.gov · COMPLETED, 2017
• A Clinical Study for Assessing the Effect of Change of Bile Acid Pool on the Pharmacodynamics and Safety of Metformin and Intestinal Microbiome Profiles in Healthy Volunteers ClinicalTrials.gov · COMPLETED, 2020
• A Phase 1, Open-Label, 4-Part Trial to Assess the Drug-Drug Interaction Between Zasocitinib and Combined Oral Contraceptives, a MATE Substrate, a P-gp Substrate, and a Proton-Pump Inhibitor in Healthy Participants ClinicalTrials.gov · COMPLETED, 2025
• Effects of GLP-1 Analogue Combined With Metformin and Metformin on Gonadal and Metabolic Profiles in Chinese Overweight/Obese PCOS Patients With Hyperandrogenemia ClinicalTrials.gov · COMPLETED, 2022
• A Single-Dose, Open-Label, Randomized, 2-Way Crossover Pivotal Study to Assess the Bioequivalence of 2 FDC Tablets of Canagliflozin and Metformin IR (150 mg/500 mg) With Respect to the Individual Components of Canagliflozin (1x300 mg) and Metformin IR Tablets (2x500 mg) in Healthy Fed Subjects ClinicalTrials.gov · COMPLETED, 2012
• Effect of Aerobic Exercise on Inflammatory Markers in Polycystic Ovary Syndrome ClinicalTrials.gov · COMPLETED, 2021
• Improving Compliance With Metformin ClinicalTrials.gov · COMPLETED, 2005
• A 52-Week, Multi-Centre, Randomised, Parallel-Group, Double-Blind, Active Controlled, Phase IV Study to Evaluate the Safety and Efficacy of Dapagliflozin or Dapagliflozin Plus Saxagliptin Compared With Sulphonylurea All Given as Add-on Therapy to Metformin in Adult Patients With Type 2 Diabetes Who Have Inadequate Glycaemic Control on Metformin Monotherapy ClinicalTrials.gov · COMPLETED, 2017
• A Randomized Open-label, Repeat Dose, Two Sequence Cross-Over Study to Determine the Effect of GSK189075 on the Pharmacokinetic Parameters of Metformin (Glucophage) in Subjects With Type 2 Diabetes Mellitus ClinicalTrials.gov · COMPLETED, 2006
• Modulating Endoplasmic Reticulum Stress as a Prophylactic Approach Against Symptomatic Viral Infection ClinicalTrials.gov · COMPLETED, 2023
• Repurposing Metformin for the Treatment of Oral Submucous Fibrosis: Unraveling Novel Signaling Pathways In Vitro and Advancing to Clinical Trial" ClinicalTrials.gov · COMPLETED, 2025
• A multicenter, randomized, double-blind, placebo-controlled, phase III study to assess the efficacy, safety and tolerability of aleglitazar plus metformin combination therapy compared with placebo plus metformin in patients with type 2 diabetes mellitus inadequately controlled with metformin monotherapy ClinicalTrials.gov · COMPLETED, 2013
• A Randomized, Three-Treatment, Three-Period, Six-Sequence, Single-Dose, Crossover Pharmacokinetic Study on Metformin Hydrochloride Solution 100 mg/mL of Ranbaxy Laboratories Comparing the Pharmacokinetic Profile of Metformin Under Fasting Condition, After a Low Fat Meal and After a High Fat Meal in Healthy, Adult, Human Male Subjects ClinicalTrials.gov · COMPLETED, 2002
• Effects of Pioglitazone on Endothelial Progenitor Cells in Type 2 Diabetic Patients With Vascular Complications - The SPLENDOR Study ClinicalTrials.gov · COMPLETED, 2011
• A Randomized, Open-label, Multiple Dosing, Three-way Crossover Clinical Trial to Investigate the Pharmacokinetic Drug-drug Interaction of Gemigliptin and Metformin After Oral Administration in Healthy Mexican Male Subjects ClinicalTrials.gov · COMPLETED, 2016
• A 24-week, Multi-center, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Assess the Efficacy and Safety of Vildagliptin 50mg Bid as an add-on Therapy to Insulin, With or Without Metformin, in Patients With Type 2 Diabetes Mellitus ClinicalTrials.gov · COMPLETED, 2013
• A Phase 3, Randomized, Double-blind, Active-controlled Study to Evaluate the Effects of Bexagliflozin Versus Glimepiride in Subjects With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control by Metformin ClinicalTrials.gov · COMPLETED, 2019
• Risk Reduction in Coronary Heart Disease - a Prospective Randomized Study ClinicalTrials.gov · COMPLETED, 2019
• A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter, 24-week Study Followed by an Extension Assessing the Efficacy and Safety of AVE0010 in Two Titration Regimens on Top of Metformin in Patients With Type 2 Diabetes Not Adequately Controlled With Metformin ClinicalTrials.gov · COMPLETED, 2011
• Novel Actions of Metformin to Augment Resistance Training Adaptations in Older Adults ClinicalTrials.gov · COMPLETED, 2018
• A Randomized, Open-label, Multiple-dose, Crossover Phase I Clinical Study to Evaluate DW1029M Influence the Pharmacokinetic Profiles of Metformin After Oral Administration in Healthy Male Volunteer ClinicalTrials.gov · COMPLETED, 2015
• A Randomized, Open-label, Single Dose, 2x2 Crossover Trial to Evaluate the Food Effect on the Bioavailability of a Metformin/Gliclazide Fixed Combination Tablet (1000 mg /30 mg MR) Given in Fasting and Fed Conditions to Healthy Volunteers ClinicalTrials.gov · COMPLETED, 2018
• A Clinical Trial Comparing Efficacy and Safety of Insulin Degludec/Liraglutide (IDegLira) in Subjects With Type 2 Diabetes Mellitus Using Two Different Titration Algorithms ClinicalTrials.gov · COMPLETED, 2015
• Efficacy and Safety of FIAsp Compared to Insulin Aspart in Combination With Insulin Glargine and Metformin in Adults With Type 2 Diabetes ClinicalTrials.gov · COMPLETED, 2015
• Effects of Vildagliptin, a DPP-4 Inhibitor, in Elderly Diabetic Patients With Mild Cognitive Impairment ClinicalTrials.gov · COMPLETED, 2016
• A Multicenter, Randomized, Double-Blind, Phase 3 Trial to Evaluate the Efficacy and Safety of Saxagliptin Added to Insulin Monotherapy or to Insulin in Combination With Metformin in Subjects With Type 2 Diabetes Who Have Inadequate Glycemic Control on Insulin Alone or on Insulin in Combination With Metformin ClinicalTrials.gov · COMPLETED, 2010
• Effect of Sodium Glucose Co-transporter 2 Inhibitor on Inflammatory Cytokine in Type 2 Diabetes ClinicalTrials.gov · COMPLETED, 2017
• A Prospective Open-label Trial of Metformin for Weight Control of Pediatric Patients on Atypical Antipsychotic Medications ClinicalTrials.gov · COMPLETED, 2007
• Phase I/II Trial of Vandetanib in Combination With Metformin in Subjects With HLRCC or SDH-Associated Kidney Cancer or Sporadic Papillary Renal Cell Carcinoma ClinicalTrials.gov · TERMINATED, 2020
• Open, Randomized, Phase I Study in Subjects With Type 2 Diabetes Mellitus Treated With Metformin to Evaluate the Effect of AZD1656 on the Pharmacokinetics of Pioglitazone and Vice Versa ClinicalTrials.gov · COMPLETED, 2010
• A Randomized, 30-week, Active-controlled, Open-label, 2 Treatment-arm, Parallel Group, Multicenter Study Comparing Efficacy and Safety of iGlarLixi to Insulin Glargine With or Without Metformin in Patients With Type 2 Diabetes Mellitus Insufficiently Controlled on Basal Insulin With or Without Oral Antidiabetic Drug(s) ClinicalTrials.gov · COMPLETED, 2020
• A 2-week, Randomised, Controlled, Open-label, Two-group Parallel, Multi-centre Trial Comparing Efficacy and Safety of Insulin Detemir Plus Insulin Aspart and NPH Insulin Plus Human Soluble Insulin Both in a Basal Bolus Regimen With or Without Metformin in Chinese Inpatients With Type 2 Diabetes Currently Treated With Insulin Qualifying for Intensified Treatment ClinicalTrials.gov · TERMINATED, 2012
• Influence of an Amino Acid and Chromium Containing Table Water on Glucose Response to a Test Meal in Type 2 Diabetes Patients in a Double Blind Cross - Over Design ClinicalTrials.gov · COMPLETED, 2015
• Biomolecular mode of action of metformin in relation to its copper binding properties Biochemistry, 2014
• Harnessing Metformin's Immunomodulatory Effects on Immune Cells to Combat Breast Cancer International journal of molecular sciences, 2024
• Metformin influences cardiomyocyte cell death by pathways that are dependent and independent of caspase-3 Diabetologia, 2006
• Protective Effects of Metformin Against Biochemical Failure Following Radical Prostatectomy or Radiation Therapy in Localized Prostate Cancer Urology, 2021
• The importance of the AMPK gamma 1 subunit in metformin suppression of liver glucose production Scientific reports, 2020
• Old drug, new trick: repurposing metformin for gynecologic cancers? Gynecologic oncology, 2014
• Repurposing metformin to treat age-related neurodegenerative disorders and ischemic stroke Life sciences, 2021
• The Antinociceptive Effects and Sex-Specific Neurotransmitter Modulation of Metformin in a Mouse Model of Fibromyalgia Cells, 2024
• Hypothesis: Metformin is a potential reproductive toxicant Frontiers in endocrinology, 2022
• Metformin and its derivatives in breast cancer: from glycaemic control to tumor-intrinsic pathways Breast cancer research : BCR, 2025
• NF-κB as the mediator of metformin's effect on ageing and ageing-related diseases Clinical and experimental pharmacology & physiology, 2019
• Novel applications of metformin in the treatment of septic myocardial injury based on metabolomics and network pharmacology European journal of pharmacology, 2025
• The population-specific Thr44Met OCT3 coding variant affects metformin pharmacokinetics with subsequent effects on insulin sensitivity in C57Bl/6J mice Diabetologia, 2025
• Is metformin beneficial for heart failure in patients with type 2 diabetes? Diabetes research and clinical practice, 2018
• Ex silico engineering of cystine-dense peptides yielding a potent bispecific T cell engager Science Translational Medicine, 2022
• Drug‐Like ProteinProtein Interaction Modulators: Challenges and Opportunities for Drug Discovery and Chemical Biology Molecular Informatics, 2014
• Genome-wide identification, in silico characterization and expression analysis of the RNA helicase gene family in chickpea (C. arietinum L.) Scientific Reports, 2022
• Genome-Wide Association Study Dissects the Genetic Architecture of Seed Weight and Seed Quality in Rapeseed (Brassica napus L.) DNA Research, 2014
• Asymmetric synthesis of enantiopure tetracyclic dispirooxindolopyrrolidine-piperidones via microwave-assisted multicomponent reaction: Crystallographic analysis, antimicrobial activity and in silico studies Journal of Molecular Structure, 2024
• Thin patient‐specific clavicle fracture fixation plates can mechanically outperform commercial plates: An in silico approach Journal of Orthopaedic Research®, 2021
• Toward Efficient Bactericidal and Dye Degradation Performance of Strontium- and Starch-Doped Fe 2 O 3 Nanostructures: In Silico Molecular Docking Studies ACS Omega, 2023
• Spliced HLA-bound peptides: a Black Swan event in immunology Clinical & Experimental Immunology, 2021
• The Human Gene Mutation Database: towards a comprehensive repository of inherited mutation data for medical research, genetic diagnosis and next-generation sequencing studies Human Genetics, 2017
• Identification of SARS-CoV-2 inhibitors targeting Mpro and PLpro using in-cell-protease assay Communications Biology, 2022
• John Wheeler Between Cold Matter and Frozen Stars: The Road Towards Black Holes MPG.PuRe (Max Planck Society), 2021
• A Survey on Knowledge Graphs: Representation, Acquisition, and Applications IEEE Transactions on Neural Networks and Learning Systems, 2021
• Mechanical strength of 3D-printed open hole polymer plates Procedia Structural Integrity, 2022
• Structural and functional diversities in lepidopteran serine proteases Cellular & Molecular Biology Letters, 2006
• In-silico testing of new pharmacology for restoring inhibition and human cortical function in depression Communications Biology, 2024
• In vitro and in silico methods for the biomechanical assessment of osseointegrated transfemoral prostheses: a systematic review Frontiers in Bioengineering and Biotechnology, 2023
• Unveiling Glucosinolate Diversity in Brassica Germplasm and In Silico Analysis for Determining Optimal Antioxidant Potential Antioxidants, 2024
• Construction and validation of a multi-epitope in silico vaccine model for lymphatic filariasis by targeting Brugia malayi: a reverse vaccinology approach Bulletin of the National Research Centre/Bulletin of the National Research Center, 2023
• In Silico Structure and Sequence Analysis of Bacterial Porins and Specific Diffusion Channels for Hydrophilic Molecules: Conservation, Multimericity and Multifunctionality International Journal of Molecular Sciences, 2016
• Toxicity of nanomaterials Chemical Society Reviews, 2011
• In silico study of subtilisin-like protease 1 (SUB1) from different Plasmodium species in complex with peptidyl-difluorostatones and characterization of potent pan-SUB1 inhibitors Journal of Molecular Graphics and Modelling, 2016
• Evolution of Interferon-Gamma Aptamer with Good Affinity and Analytical Utility by a Rational In Silico Base Mutagenesis Post-SELEX Strategy Molecules, 2022
• Phytochemical investigations, in-vitro antioxidant, antimicrobial potential, and in-silico computational docking analysis of Euphorbia milii Des Moul Journal of Experimental Biology and Agricultural Sciences, 2023
• Opioid Activation of Toll-Like Receptor 4 Contributes to Drug Reinforcement Journal of Neuroscience, 2012
• Modelling intra-muscular contraction dynamics using in silico to in vivo domain translation BioMedical Engineering OnLine, 2022
• Actomyosin meshwork mechanosensing enables tissue shape to orient cell force Nature Communications, 2017
• Detectability and accuracy of computational measurements of in-silico and physical representations of enlarged perivascular spaces from magnetic resonance images Journal of Neuroscience Methods, 2023
• Biofilm formation at the air–liquid interface by the Pseudomonas fluorescens SBW25 wrinkly spreader requires an acetylated form of cellulose Molecular Microbiology, 2003
• Isolation, Crystal Structure, and In Silico Aromatase Inhibition Activity of Ergosta-5, 22-dien-3β-ol from the Fungus Gyromitra esculenta Journal of Chemistry, 2021
• Xanthine oxidase, α-glucosidase and α-amylase inhibitory activities of the essential oil from Piper lolot: In vitro and in silico studies Heliyon, 2023
• In Silico and In Vitro Analysis of Major Cannabis-Derived Compounds as Fatty Acid Amide Hydrolase Inhibitors Molecules, 2020
• An Integrated In Vitro–In Silico Approach for Silver Nanoparticle Dosimetry in Cell Cultures Annals of Biomedical Engineering, 2020
• Soft System Based on Fiber Bragg Grating Sensor for Loss of Resistance Detection during Epidural Procedures: In Silico and In Vivo Assessment Sensors, 2021
• In Silico Prediction Analysis of Idiotope-Driven T–B Cell Collaboration in Multiple Sclerosis Frontiers in Immunology, 2017
• Neuropharmacological, Antidiarrheal, and Antimicrobial Effects of Chaetomorpha aerea Acetone Extract: GC‐MS Profiling and In Silico Analysis Scientifica, 2025
• Simultaneous detection and differentiation of Rice black streaked dwarf virus (RBSDV) and Southern rice black streaked dwarf virus (SRBSDV) by duplex real time RT-PCR Virology Journal, 2013
• Insights into the Interactions of Fasciola hepatica Cathepsin L3 with a Substrate and Potential Novel Inhibitors through In Silico Approaches PLoS neglected tropical diseases, 2015
• Is Hypoxia a Factor Influencing PSMA-Directed Radioligand Therapy?—An In Silico Study on the Role of Chronic Hypoxia in Prostate Cancer Cancers, 2021
• Molybdenum-doped iron oxide nanostructures synthesized via a chemical co-precipitation route for efficient dye degradation and antimicrobial performance: in silico molecular docking studies RSC Advances, 2022
• Model-Informed Drug Development: In Silico Assessment of Drug Bioperformance following Oral and Percutaneous Administration Pharmaceuticals, 2024
• Cardiovascular disease models: A game changing paradigm in drug discovery and screening Biomaterials, 2018
• Photocatalytic and antibacterial activity of graphene oxide/cellulose-doped TiO 2 quantum dots: in silico molecular docking studies Nanoscale Advances, 2022
• In Silico Analysis of a MRP Transporter Gene Reveals Its Possible Role in Anthocyanins or Flavonoids Transport in Oryze sativa American Journal of Plant Sciences, 2013
• Revisiting the Specificity of PCR Primers for Diagnostics of Xanthomonas citri pv. citri by Experimental and In Silico Analyses Plant Disease, 2013
• In Silico Prediction of the Chemical Block of Human Ether-a-Go-Go-Related Gene (hERG) K+ Current The Journal of Physiological Sciences, 2008
• In Silico Electrophysiology of Inner-Ear Mechanotransduction Channel TMC1 Models bioRxiv (Cold Spring Harbor Laboratory), 2021
• Poroelasticity as a Model of Soft Tissue Structure: Hydraulic Permeability Reconstruction for Magnetic Resonance Elastography in Silico Frontiers in Physics, 2021