Browse studies, page 1305

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Multiple drug transporters contribute to the brain transfer of levofloxacin CNS Neuroscience & Therapeutics, 2022
Exploring anti-malarial potential of FDA approved drugs: an in silico approach Malaria Journal, 2017
Isolation, characterization, anti-MRSA evaluation, and in-silico multi-target anti-microbial validations of actinomycin X2 and actinomycin D produced by novel Streptomyces smyrnaeus UKAQ_23 Scientific Reports, 2021
Synthesis and potential antitumor activity of 7-(4-substituted piperazin-1-yl)-4-oxoquinolines based on ciprofloxacin and norfloxacin scaffolds: in silico studies Journal of Enzyme Inhibition and Medicinal Chemistry, 2015
Moxifloxacin plus rifampin as an alternative for levofloxacin plus rifampin in the treatment of a prosthetic joint infection with Staphylococcus aureus International Journal of Antimicrobial Agents, 2017
Levofloxacin is phytotoxic and modifies the protein profile of lupin seedlings Environmental Science and Pollution Research, 2017
In silico identification of two peptides with antibacterial activity against multidrug-resistant Staphylococcus aureus npj Biofilms and Microbiomes, 2022
Electrochemical degradation of levofloxacin in synthetic hospital effluents: insights into operating parameters, by-products formation and toxicity Electrochimica Acta, 2025
Synthesis, characterization, and in vitro antibacterial activity of some new pyridinone and pyrazole derivatives with some in silico ADME and molecular modeling study Journal of the Iranian Chemical Society, 2022
The SOS Response Master Regulator LexA Is Associated with Sporulation, Motility and Biofilm Formation in Clostridium difficile PLoS ONE, 2015
Drug‐induced shortening of the electromechanical window is an effective biomarker for in silico prediction of clinical risk of arrhythmias British Journal of Pharmacology, 2019
Pediatric tuberculous meningitis: Model-based approach to determining optimal doses of the anti-tuberculosis drugs rifampin and levofloxacin for children Clinical Pharmacology & Therapeutics, 2015
The degradation of levofloxacin in infusions exposed to daylight with an identification of a degradation product with HPLC-MS Scientific Reports, 2019
Ciprofloxacin and moxifloxacin could interact with SARS-CoV-2 protease: preliminary in silico analysis Pharmacological Reports, 2020
Identification and Characterization of Potential Therapeutic Candidates in Emerging Human Pathogen Mycobacterium abscessus: A Novel Hierarchical In Silico Approach PLoS ONE, 2013
The Trends and Future Prospective of In Silico Models from the Viewpoint of ADME Evaluation in Drug Discovery Pharmaceutics, 2023
Development and evaluation of a generic physiologically based pharmacokinetic model for children Clinical Pharmacokinetics, 2006
Identification of Natural Compound Inhibitors for Multidrug Efflux Pumps of Escherichia coli and Pseudomonas aeruginosa Using In Silico High-Throughput Virtual Screening and In Vitro Validation PLoS ONE, 2014
Network-based in silico drug efficacy screening Nature Communications, 2016
Molecular Docking Analysis of Coumarin and Indole Derivatives Targeting the MexB and GyrB in Multidrug-resistant Pseudomonas aeruginosa Clinical Isolates Journal of Pure and Applied Microbiology, 2026
Sequence Variation and Structural Insights into Porin Genes (OmpF, OmpC) of Wastewater-Derived Escherichia coli : A Molecular and Bioinformatics Approach Journal of Computational Biophysics and Chemistry, 2025
Genomic insights into virulence, biofilm formation and antimicrobial resistance of multidrug-resistant Helicobacter pylori strains of novel sequence types isolated from Vietnamese patients with gastric diseases Journal of Global Antimicrobial Resistance, 2025
Introduction pages, Notulae Scientia Biologicae 17(1), 2025 Notulae Scientia Biologicae, 2025
Physicochemical properties of lomefloxacin, levofloxacin, and moxifloxacin relevant to the biopharmaceutics classification system Acta Chimica Slovenica, 2014
Development of novel in silico model to predict corneal permeability for congeneric drugs: a QSPR approach Journal of Biomedicine and Biotechnology, 2011
Synthesis of Novel Hydrazones of Levofloxacin related molecule and their In Vitro evaluation as antioxidant, and Molecular Docking Studies Combinatorial chemistry & high throughput screening, 2020
Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach PLoS Comput. Biol., 2017
Detection of OXA-1 β-lactamase gene of Klebsiella pneumoniae from blood stream infections (BSI) by conventional PCR and in-silico analysis to understand the mechanism of OXA mediated resistance PLoS ONE, 2014
Structure based in silico analysis of quinolone resistance in clinical isolates of Salmonella Typhi from India PLoS ONE, 2015
COX-2 Enzyme Inhibitors Study and Efficacy Pharmacokinetic by Molecular Docking for some New Heterocyclic Rings Driver from Levofloxacin Drug Russian journal of bioorganic chemistry, 2023
In Silico Drug Design and Molecular Docking Studies of Some Quinolone Compound Molecular Docking and Molecular Dynamics, 2019
In silico and In vitro Evaluation of Some Synthesized Quinoline Derivatives into MexB Protein of Pseudomonas aeruginosa International Journal of Drug Delivery Technology, 2020
The search of potential inhibitors of the AcrAB-TolC system of multidrug-resistant Escherichia coli: an in silico approach Applied Microbiology and Biotechnology, 2019
Exploring the phototransformation and assessing the in vitro and in silico toxicity of a mixture of pharmaceuticals susceptible to photolysis Science of the Total Environment, 2020
Origin of macromolecular crowding: Analysis of recognition mechanism of dual-template molecularly imprinted polymers by in silico prediction Journal of Chromatography A, 2021
Chromanone Oxime Analogs of Quinolone Drugs as Cytotoxic Agents: In Vitro Cytotoxicity Evaluation and In Silico Study Biointerface Research in Applied Chemistry, 2022
In vitro and in silico interactions of antiulcer, glucocorticoids and urological drugs on human carbonic anhydrase I and II isozymes Biopharmaceutics & drug disposition, 2022
Design, synthesis, in vitro and in silico bioactivity profiles of new urea/thiourea derivatives of 2-pyridyl piperazine as potent antioxidant and antimicrobial agents: chemo-bio-computational approach Journal of Biomolecular Structure and Dynamics, 2022
In silico and in vitro genotoxicity evaluation of levofloxacin n-oxide, an impurity in levofloxacin Toxicology Mechanisms and Methods, 2012
In Silico Docking, Resistance Modulation and Biofilm Gene Expression in Multidrug-Resistant Acinetobacter baumannii via Cinnamic and Gallic Acids Antibiotics, 2022
Studi in Silico Senyawa Fitokimia Daun Ketepeng Cina (Cassia alata) sebagai kandidat antibakteri Staphylococcus aureus Penyebab Impetigo BIOEDUSAINS Jurnal Pendidikan Biologi dan Sains, 2026
Design, synthesis, characterization, pharmacological evaluation and in silico ADMET and molecular docking and dynamics simulations of a novel series of N-substituted pyrazole from chalcone derivatives Scientific Reports, 2026
Growth inhibition of P. aeruginosa by methanol extract of Bridelia stipularis and identification of active components using in silico studies Future Journal of Pharmaceutical Sciences, 2024
Activity of Fluoroquinolones and Proton Pump Inhibitors against Resistant Oral Bacterial Biofilms, in silico and in vitro Analysis Polish Journal of Microbiology, 2024
“In Silico” prediction of antibiotics biodegradation by Ganoderma lucidum GILCC 1 laccase Discover Applied Sciences, 2024
Antiurease Activity of Antibiotics: In Vitro, In Silico, Structure Activity Relationship, and MD Simulations of Cephalosporins and Fluoroquinolones ACS Omega, 2024
Doxycycline post exposure prophylaxis could theoretically select for resistance to various antimicrobials in 19 pathobionts: an in silico analysis International Journal of Infectious Diseases, 2024
In silico Analysis to Search for an Alternative Inhibitor of Biofilm Production by Helicobacter pylori Current Drug Discovery Technologies, 2025
Exploring Novel Tetrahydropyrimidine and Fused Pyrimidine-Based Compounds as DHFR Inhibitors and Antimicrobial Agents: Synthesis, In Vitro, In Vivo, and In Silico Studies Drug development research (Print), 2025
In silico trials using Monte Carlo simulation to evaluate ciprofloxacin and levofloxacin dosing in critically ill patients receiving prolonged intermittent renal replacement therapy Renal Replacement Therapy, 2016
Exploring the potential role of GyrA inhibiting quinoline analog: an in silico study Scientific Reports, 2025
TiO₂-modified activated carbon for pharmaceutical contaminant removal: experimental and in-silico insights using density functional theory Journal of Environmental Health Science and Engineering, 2025
Prediction and mechanism of combined toxicity of surfactants and antibiotics in aquatic environment based on in silico method Journal of Hazardous Materials, 2025
Microwave-assisted synthesis and in vitro and in silico studies of pyrano[3,2-c]quinoline-3-carboxylates as dual acting anti-cancer and anti-microbial agents and potential topoisomerase II and DNA-gyrase inhibitors RSC Advances, 2025
The Effects of P‐glycoprotein Modulators on the Transition of Levofloxacin to Rat Brain, Testicle, and Plasma: In Vivo and In Silico Studies ChemistrySelect, 2021
The application of in silico experimental model in the assessment of ciprofloxacin and levofloxacin interaction with main SARS-CoV-2 targets: S-, E- and TMPRSS2 proteins, RNA-dependent RNA polymerase and papain-like protease (PLpro)-preliminary molecular docking analysis Pharmacological Reports, 2021
In Silico Evaluation of Doxorubicin and Levofloxacin as Multi-Isoform PI3K Inhibitors: Molecular Docking, Molecular Dynamics Simulations, and MM/PBSA Analysis Bulletin of Pharmaceutical Sciences Assiut University, 2026
Levofloxacin and sulfa drugs linked via Schiff bases: Exploring their urease inhibition, enzyme kinetics and in silico studies Journal of Molecular Structure, 2021
In Silico Activity Prediction and Docking Studies of the Binding Mechanisms of Levofloxacin Structure Derivatives to Active Receptor Sites of Bacterial Type IIA Topoisomerases Scientia Pharmaceutica, 2023
In Silico Molecular Docking, Synthesis and Preliminary Evaluation of Antibacterial Activity of Levofloxacin Carboxamides with Certain Amino Acids Al Mustansiriyah Journal of Pharmaceutical Sciences, 2023
Novel Fluoroquinolones with Possible Antibacterial Activity in Gram-Negative Resistant Pathogens: In Silico Drug Discovery Molecules (Basel, Switzerland), 2023
Montelukast treats Streptococcus pneumoniae-induced sepsis via antibacterial and anti-inflammatory activities Microbiology spectrum, 2025
Synthesis, characterization and bio-evaluation of novel series of pyrazoline derivatives as potential antifungal agents Scientific reports, 2025
Structural characterization, derivatization, and bioactivities of secondary metabolites produced by termite-associated Streptomyces lannensis BYF-106 Microbiology spectrum, 2025
Synergistic Effects of Pyrrosia lingua Caffeoylquinic Acid Compounds with Levofloxacin Against Uropathogenic Escherichia coli: Insights from Molecular Dynamics Simulations, Antibiofilm, and Antimicrobial Assessments Molecules (Basel, Switzerland), 2024
Bioinformatics Analysis of the Anti-Inflammatory Mechanism and Potential Therapeutic Efficacy of Kezimuke granules in Treating Urinary Tract Infections by Inhibiting NLRP3 Inflammasome Activation International journal of molecular sciences, 2025
Natural Inhibitors of Salmonella MDR Efflux Pumps AcrAB and AcrD: An Integrated In Silico, Molecular, and In Vitro Investigation International journal of molecular sciences, 2024
Discovery of novel uridine-based chitin synthase inhibitors: Design, synthesis and structure-activity relationships Pest management science, 2026
Multimodal computational discovery of MvfR inhibitors targeting quorum sensing in multi-drug-resistant Pseudomonas aeruginosa Scientific reports, 2026
Design, Synthesis, and Anti-Biofilm Activity of C-28 Modified Betulinic Acid Derivatives Targeting SarA in Drug-Resistant Staphylococcus aureus Microorganisms, 2026
R5 and R7 positions on fluoroquinolone scaffolds drive F-actin filament disruption Scientific reports, 2026
Exploration of pyrazole-based pyridine-4-carbohydrazide derivatives as drug-resistant Mtb agents: design, synthesis, biological evaluation, and in-silico studies Future medicinal chemistry, 2025
Molecular diversity and evolutionary dynamics of phage receptor binding proteins in Staphylococcus aureus: implications for phage therapy and resistance Scientific reports, 2026
Synthesis, antibacterial evaluation, and DNA gyrase inhibition profile of some new quinoline hybrids Archiv der Pharmazie, 2019
Genomic and epidemiological characterization of a blaCTX-M-27-carrying ST34 Salmonella enterica serotype Typhimurium in China Journal of global antimicrobial resistance, 2024
Therapeutic potential activity of quercetin complexes against Streptococcus pneumoniae Scientific reports, 2024
Comparative molecular profiling of multidrug-resistant Pseudomonas aeruginosa identifies novel mutations in regional clinical isolates from South India JAC-antimicrobial resistance, 2024
Antimicrobial Resistance in Clinical Ureaplasma spp. and Mycoplasma hominis and Structural Mechanisms Underlying Quinolone Resistance Antimicrobial agents and chemotherapy, 2020
Molecular Interactions of Fluoroquinolone Antibiotics with Lipid Membranes Langmuir : the ACS journal of surfaces and colloids, 2026
In silico discovery of druggable targets in Citrobacter koseri using echinoderm metabolites and molecular dynamics simulation Scientific reports, 2024
Genomic Features, Comparative Genomics, and Antimicrobial Susceptibility Patterns of Elizabethkingia bruuniana Scientific reports, 2019
VIVO complexes with antibacterial quinolone ligands and their interaction with serum proteins Dalton transactions (Cambridge, England : 2003), 2018
Molecular determinants of the bacterial resistance to fluoroquinolones: a computational study Current computer-aided drug design, 2013
In Silico Screening and In Vitro Assessment of Natural Products with Anti-Virulence Activity against Helicobacter pylori Molecules (Basel, Switzerland), 2021
Characteristics of a Carbapenem-Resistant Acinetobacter baumannii Strain Causing Community-Acquired Pneumonia in a Young Healthy Women Infection and drug resistance, 2023
Mechanistic study of the electrochemical oxidation of fluoroquinolones: Ciprofloxacin, danofloxacin, enoxacin, levofloxacin and lomefloxacin Chemosphere, 2024
Levofloxacin alleviates blood-brain barrier disruption following cerebral ischemia and reperfusion via directly inhibiting A-FABP. European journal of pharmacology, 2024
Design, synthesis, molecular docking, anti-Proteus mirabilis and urease inhibition of new fluoroquinolone carboxylic acid derivatives Bioorganic chemistry, 2017
Phylogenic analysis of coronavirus genome and molecular studies on potential anti-COVID-19 agents from selected FDA-approved drugs Journal of biomolecular structure & dynamics, 2022
Estimation of country-specific tuberculosis resistance antibiograms using pathogen genomics and machine learning BMJ global health, 2024
In silico and in vitro genotoxicity evaluation of descarboxyl levofloxacin, an impurity in levofloxacin Drug and chemical toxicology, 2014
Homology modeling, molecular dynamics, and virtual screening of NorA efflux pump inhibitors of Staphylococcus aureus Drug design, development and therapy, 2016
Study of andrographolide bioactivity against Pseudomonas aeruginosa based on computational methodology and biochemical analysis Frontiers in chemistry, 2024
Identifying 24 h variation in the pharmacokinetics of levofloxacin: a population pharmacokinetic approach British journal of clinical pharmacology, 2016
Identification and Antibiotic Profiling of Wohlfahrtiimonas chitiniclastica, an Underestimated Human Pathogen Frontiers in microbiology, 2021
Interaction of levofloxacin with lung surfactant at the air-water interface Colloids and surfaces. B, Biointerfaces, 2017
Could Respiratory Fluoroquinolones, Levofloxacin and Moxifloxacin, Prove to be Beneficial as an Adjunct Treatment in COVID-19? Archives of medical research, 2020
Drug Repurposing Based on Protozoan Proteome: In Vitro Evaluation of In Silico Screened Compounds against Toxoplasma gondii Pharmaceutics, 2022
Ab initio molecular dynamics simulations and experimental speciation study of levofloxacin under different pH conditions Physical chemistry chemical physics : PCCP, 2021
Molecular epidemiology and antibiotic resistance profiling of Staphylococcus aureus isolates from camel mastitis Microbial pathogenesis, 2025