Browse studies, page 1211
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- Early-Onset Type 2 Diabetes and Tirzepatide Treatment: A Post Hoc Analysis From the SURPASS Clinical Trial Program Diabetes care, 2024
- Long-term efficacy and safety of tirzepatide in participants with type 2 diabetes with inadequate glycaemic control on metformin and/or sulfonylurea: Post-hoc analysis of SURPASS-4 Diabetes, obesity & metabolism, 2025
- Tirzepatide and muscle composition changes in people with type 2 diabetes (SURPASS-3 MRI): a post-hoc analysis of a randomised, open-label, parallel-group, phase 3 trial The lancet. Diabetes & endocrinology, 2025
- Effect of a Probiotic and Metformin on Liver Aminotransferases in Non-alcoholic Steatohepatitis: A Double Blind Randomized Clinical Trial International Journal of Preventive Medicine, 2013
- Efficacy and safety of once‐weekly semaglutide versus once‐daily sitagliptin as add‐on to metformin in patients with type 2 diabetes in SUSTAIN China: A 30‐week, double‐blind, phase 3a, randomized trial Diabetes, obesity and metabolism, 2020
- The metformin in tuberous sclerosis (MiTS) study: A randomised double-blind placebo-controlled trial EClinicalMedicine, 2021
- Randomized Trial of Metformin With Anti-Tuberculosis Drugs for Early Sputum Conversion in Adults With Pulmonary Tuberculosis Clinical Infectious Diseases, 2021
- Metformin versus chromium picolinate in clomiphene citrate-resistant patients with PCOs: A double-blind randomized clinical trial Iranian Journal of Reproductive Medicine, 2013
- Effects of once-weekly semaglutide vs once-daily canagliflozin on body composition in type 2 diabetes: a substudy of the SUSTAIN 8 randomised controlled clinical trial Diabetologia, 2020
- The Effect of Pioglitazone and Metformin on Liver Function Tests, Insulin Resistance, and Liver Fat Content in Nonalcoholic Fatty Liver Disease: A Randomized Double Blinded Clinical Trial Hepatitis Monthly, 2013
- Inhibition of mTOR signaling and clinical activity of metformin in oral premalignant lesions JCI Insight, 2021
- Primary results of the randomized trial of metformin administration in polycystic kidney disease (TAME PKD) Kidney International, 2021
- MeDiGes Study. Metformin versus insulin in gestational diabetes: Glycemic control, and obstetrical and perinatal outcomes. Randomized prospective trial American Journal of Obstetrics and Gynecology, 2021
- Antiproliferative and metabolic effects of metformin in a preoperative window clinical trial for endometrial cancer Cancer Medicine, 2014
- Diabetes, Metformin and the Clinical Course of Covid-19: Outcomes, Mechanisms and Suggestions on the Therapeutic Use of Metformin Frontiers in Pharmacology, 2022
- Effect of Vitamin E and Metformin on Fatty Liver Disease in Obese Children- Randomized Clinical Trial Iranian Journal of Public Health, 2014
- Effect of metformin on thyroid stimulating hormone and thyroid volume in patients with prediabetes: A randomized placebo-controlled clinical trial Journal of Research in Medical Sciences, 2014
- Neonatal outcomes in women with gestational diabetes mellitus treated with metformin in compare with insulin: A randomized clinical trial Journal of Research in Medical Sciences, 2014
- Complete pathological response following levonorgestrel intrauterine device in clinically stage 1 endometrial adenocarcinoma: Results of a randomized clinical trial Gynecologic Oncology, 2021
- Antiproliferative effect of metformin on the endometrium--a clinical trial Asian Pacific Journal of Cancer Prevention, 2015
- Metformin: evidence from preclinical and clinical studies for potential novel applications in cardiovascular disease Expert Opinion on Investigational Drugs, 2023
- Metformin Use and Clinical Outcomes Among Patients With Diabetes Mellitus With or Without Heart Failure or Kidney Dysfunction: Observations From the SAVOR-TIMI 53 Trial Circulation, 2019
- Lobeglitazone and pioglitazone as add‐ons to metformin for patients with type 2 diabetes: a 24‐week, multicentre, randomized, double‐blind, parallel‐group, active‐controlled, phase III clinical trial with a 28‐week extension Diabetes, obesity and metabolism, 2015
- Platelet-rich fibrin with 1% metformin for the treatment of intrabony defects in chronic periodontitis: a randomized controlled clinical trial The Journal of Periodontology, 2015
- Effect of Metformin Versus Placebo on New Primary Cancers in Canadian Cancer Trials Group MA.32: A Secondary Analysis of a Phase III Randomized Double-Blind Trial in Early Breast Cancer Journal of Clinical Oncology, 2023
- METformin for the MINimization of Geographic Atrophy Progression (METforMIN): A Randomized Trial Ophthalmology Science, 2023
- The effects of prebiotics on gastrointestinal side effects of metformin in youth: A pilot randomized control trial in youth-onset type 2 diabetes Frontiers in Endocrinology, 2023
- Letter by Mordi et al Regarding Article, "Metformin Use and Clinical Outcomes Among Patients With Diabetes Mellitus With or Without Heart Failure or Kidney Dysfunction: Observations From the SAVOR-TIMI 53 Trial". Circulation, 2020
- Efficacy of locally-delivered 1% metformin gel in the treatment of intrabony defects in patients with chronic periodontitis: a randomized, controlled clinical trial Journal of Investigative and Clinical Dentistry, 2016
- Comparing the Effects of Agnugol and Metformin on Oligomenorrhea in Patients with Polycystic Ovary Syndrome: A Randomized Clinical Trial Journal of clinical and diagnostic research : JCDR, 2016
- Randomized clinical trial of the safety and efficacy of sitagliptin and metformin co‐administered to Chinese patients with type 2 diabetes mellitus Journal of Diabetes Investigation, 2016
- Metformin in Amnestic Mild Cognitive Impairment: results of a pilot randomized placebo controlled clinical trial Journal of Alzheimer's Disease, 2016
- Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes: The SURPASS-5 Randomized Clinical Trial Journal of the American Medical Association (JAMA), 2022
- A randomised clinical trial comparing myoinositol and metformin in PCOS 2017
- The efficacy of metformin compared with insulin in regulating blood glucose levels during gestational diabetes mellitus: A randomized clinical trial Journal of Cellular Physiology, 2018
- Effects of Conjugated Linoleic Acid and Metformin on Insulin Sensitivity in Obese Children: Randomized Clinical Trial Journal of Clinical Endocrinology and Metabolism, 2017
- Randomised clinical trial: a leucine‐metformin‐sildenafil combination (NS‐0200) vs placebo in patients with non‐alcoholic fatty liver disease Alimentary Pharmacology and Therapeutics, 2018
- The synergistic effects of saxagliptin and metformin on CD34+ endothelial progenitor cells in early type 2 diabetes patients: a randomized clinical trial Cardiovascular Diabetology, 2018
- A Randomized Clinical Trial of Metformin to treat Autosomal Dominant Polycystic Kidney Disease American Journal of Nephrology, 2018
- Topical metformin in the treatment of melasma: A preliminary clinical trial Journal of Cosmetic Dermatology, 2019
- A multimodal precision-prevention approach combining lifestyle intervention with metformin repurposing to prevent cognitive impairment and disability: the MET-FINGER randomised controlled trial protocol Alzheimer's Research & Therapy, 2024
- Treatment with Metformin and Combination of Metformin Plus Pioglitazone on Serum Levels of IL-6 and IL-8 in Polycystic Ovary Syndrome: A Randomized Clinical Trial Hormone and Metabolic Research, 2019
- Study protocol of a phase IB/II clinical trial of metformin and chloroquine in patients with IDH1-mutated or IDH2-mutated solid tumours BMJ Open, 2017
- Metformin treatment significantly enhances intestinal glucose uptake in patients with type 2 diabetes: Results from a randomized clinical trial Diabetes Research and Clinical Practice, 2017
- Study protocol of a phase II clinical trial of oral metformin for the intravesical treatment of non-muscle invasive bladder cancer BMC Cancer, 2019
- The combination of Linagliptin, Metformin and Lifestyle Modification to prevent Type 2 Diabetes (PRELLIM). A randomized clinical trial Metabolism: Clinical and Experimental, 2019
- Rationale and Study Design of a Randomized Clinical Trial of Metformin to Prevent Frailty in Older Adults with Pre-Diabetes The journals of gerontology. Series A, Biological sciences and medical sciences, 2019
- Metformin induces weight loss associated with gut microbiota alteration in non-diabetic obese women: a randomized double-blind clinical trial European Journal of Endocrinology, 2019
- Mechanistic Phase II Clinical Trial of Metformin in Pulmonary Arterial Hypertension Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2020
- A phase II randomized clinical trial of the effect of metformin versus placebo on progression-free survival in women with metastatic breast cancer receiving standard chemotherapy Breast, 2019
- Effect of Metformin Plus Tyrosine Kinase Inhibitors Compared With Tyrosine Kinase Inhibitors Alone in Patients With Epidermal Growth Factor Receptor-Mutated Lung Adenocarcinoma: A Phase 2 Randomized Clinical Trial JAMA Oncology, 2019
- Metformin plus lrinotecan in patients with refractory colorectal cancer: a phase 2 clinical trial British Journal of Cancer, 2021
- Metformin for early comorbid glucose dysregulation and schizophrenia spectrum disorders: a pilot double-blind randomized clinical trial Translational Psychiatry, 2021
- Assessment of cognitive and neural recovery in survivors of pediatric brain tumors in a pilot clinical trial using metformin Nature Medicine, 2020
- Effect of Additional Oral Semaglutide vs Sitagliptin on Glycated Hemoglobin in Adults With Type 2 Diabetes Uncontrolled With Metformin Alone or With Sulfonylurea: The PIONEER 3 Randomized Clinical Trial Journal of the American Medical Association (JAMA), 2019
- A Phase Ib Clinical Trial of Metformin and Chloroquine in Patients with IDH1-Mutated Solid Tumors Cancers, 2021
- Low-Dose Metformin Reprograms the Tumor Immune Microenvironment in Human Esophageal Cancer: Results of a Phase II Clinical Trial Clinical Cancer Research, 2020
- Effect of early treatment with metformin on risk of emergency care and hospitalization among patients with COVID-19: The TOGETHER randomized platform clinical trial The Lancet Regional Health - Americas, 2021
- The Anti-Aging Mechanism of Metformin: From Molecular Insights to Clinical Applications Molecules, 2025
- Metformin in Combination With Chemoradiotherapy in Locally Advanced Non-Small Cell Lung Cancer: The OCOG-ALMERA Randomized Clinical Trial JAMA Oncology, 2021
- Addition of Metformin to Concurrent Chemoradiation in Patients With Locally Advanced Non-Small Cell Lung Cancer: The NRG-LU001 Phase 2 Randomized Clinical Trial JAMA Oncology, 2021
- Clinical Trial: Probiotics in Metformin Intolerant Patients with Type 2 Diabetes (ProGasMet) Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023
- Metformin Plus Insulin for Preexisting Diabetes or Gestational Diabetes in Early Pregnancy: The MOMPOD Randomized Clinical Trial Journal of the American Medical Association (JAMA), 2023
- Metformin Clinical Trial in HPV+ and HPV– Head and Neck Squamous Cell Carcinoma: Impact on Cancer Cell Apoptosis and Immune Infiltrate Frontiers in Oncology, 2018
- GLY-200, an oral pharmacologic duodenal exclusion drug, resulted in positive effects on glucose, lipids and bodyweight in patients with type 2 diabetes: Results of a randomized, double-blind placebo-controlled trial Diabetes, obesity & metabolism, 2025
- Acute metformin intake on exercise performance in healthy participants during functional fitness training The Journal of sports medicine and physical fitness, 2025
- Randomized Study of Metformin and Intensive Lifestyle Intervention on Cancer Incidence over 21 Years of Follow-up in the Diabetes Prevention Program Cancer prevention research (Philadelphia, Pa.), 2025
- Repairing Myelin After Irradiated Pediatric Brain Tumor: A Magnetization Transfer Imaging Analysis Pediatric blood & cancer, 2025
- Efficacy and safety benefits of HR17031, a fixed-ratio combination of INS068 and noiiglutide, versus its components alone in Chinese patients with type 2 diabetes uncontrolled on oral antidiabetic drug(s): A phase 2, multicentre, open-label, randomised, parallel three-arm, treat-to-target trial Diabetes, obesity & metabolism, 2025
- Safety analyses of the INAVO120 randomised phase III trial of inavolisib or placebo with palbociclib-fulvestrant in patients with PIK3CA-mutated, hormone receptor-positive, HER2-negative, endocrine-resistant advanced breast cancer ESMO open, 2026
- A Randomized Phase 3 Trial of Metformin in Patients Initiating Androgen Deprivation Therapy as Prevention and Intervention of Metabolic Syndrome: The PRIME Study The Journal of urology, 2025
- Combined GPR40 and GPR119 full agonism with K-757 and K-833 results in robust glucose lowering and modest weight loss in overweight/obese subjects with T2DM Diabetes, obesity & metabolism, 2025
- Association of race and survival in patients treated with apalutamide: Pooled analysis of two phase 3 trials Cancer, 2026
- Text Messaging Support for Patients Diagnosed With Impaired Glucose Tolerance During Pregnancy: Nonrandomized Pre-Post Implementation Study Assessing Impact on Postpartum Transitions of Care Journal of medical Internet research, 2026
- Efficacy and safety of chiglitazar add-on to metformin in type 2 diabetes mellitus (RECAM study) Diabetes, obesity & metabolism, 2025
- Effectiveness and Safety of Metformin, Teneligliptin, and Glimepiride Combination Therapy in Type 2 Diabetes: A Quasi Experimental Clinical Trial Current diabetes reviews, 2025
- Repurposing nitazoxanide in type 2 diabetes mellitus: a randomized controlled trial Endocrine, 2025
- Effect of Efsubaglutide Alfa on the Pharmacokinetics of Metformin and Digoxin in Healthy Participants Clinical pharmacokinetics, 2025
- "A better system" - managing the adverse effects of prescribed medicines: Cluster-randomised controlled trial and process evaluation of the ADRe Profile in primary care PloS one, 2026
- Phase-Ib dose-finding and pharmacokinetic trial of metformin combined with nivolumab for refractory/recurrent solid tumors International journal of clinical oncology, 2025
- Metformin Active Surveillance Trial in Low-Risk Prostate Cancer Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2025
- Pharmacokinetics, Pharmacodynamics, and Safety of Single-Dose Luseogliflozin (TS-071) in Japanese Children and Adolescents With Type 2 Diabetes: A Multicenter, Open-Label, Parallel-Group Phase 1 Study Clinical pharmacology in drug development, 2026
- Efficacy and safety of combining empagliflozin in people with type 2 diabetes mellitus uncontrolled with metformin and sitagliptin: A randomised, double-blind, multicentre, therapeutic confirmatory phase 3 clinical trial Diabetes, obesity & metabolism, 2026
- Efficacy and Safety of High-Dose Pioglitazone as Add-on Therapy in Patients with Type 2 Diabetes Mellitus Inadequately Controlled with Dapagliflozin and Metformin: Double-Blind, Randomized, Placebo-Controlled Trial Diabetes & metabolism journal, 2026
- MetAAA Trial Patients Receiving Metformin Therapy Show Limited Improvement in Quality of Life Compared to AAA Patients with Placebo Intake-A Double-Blind, Randomized, and Placebo-Controlled Trial Medical sciences (Basel, Switzerland), 2025
- REPAIR_GETUG P16 relapse in previously irradiated prostate bed: a phase I/II study of stereotactic ablative reirradiation potentiated by a metformine study protocol BMJ open, 2025
- Lobeglitazone improves glycaemic control as add-on therapy to empagliflozin plus metformin in patients with type 2 diabetes mellitus: A double-blind, randomised, placebo-controlled trial Diabetes, obesity & metabolism, 2026
- Rationale, design and baseline characteristics of the TRANSCEND-CKD trial of retatrutide in patients with chronic kidney disease Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2026
- Inpatient safety, effectiveness of SGLT2 inhibitors and GLP-1 RAs in type 2 diabetes: ENDOCARE, a pragmatic prospective cohort study Cardiovascular diabetology, 2026
- Safety and tolerability of metformin in overweight and obese patients with dengue: An open-label clinical trial (MeDO) PLoS neglected tropical diseases, 2025
- Safety and efficacy of GZR18, a long-acting GLP-1 analog, in Chinese patients with type 2 diabetes: A randomized, double-blind, phase 1b/2a trial Cell reports. Medicine, 2026
- Time-Restricted Eating and Metformin in Invasive Breast Cancer or DCIS: A Randomized, Phase IIb, Presurgical Trial. Preliminary Safety Analysis Cancer prevention research (Philadelphia, Pa.), 2026
- Dual Glucagon and GLP-1 Receptor Agonist Survodutide Improves Biomarkers of Beta-Cell Function and Insulin Sensitivity in People With Type 2 Diabetes or Living With Overweight/Obesity Diabetes, obesity & metabolism, 2026
- Anti-diabetic medications to fight Parkinson's disease and dementia with Lewy bodies: a pilot study Frontiers in neurology, 2026
- Semaglutide Injection in Indian Patients With Type 2 Diabetes Mellitus: A Randomised, Phase III, Active-Controlled Study Diabetes, obesity & metabolism, 2026
- Diabetes prevention in the Caribbean using lifestyle intervention and Metformin escalation (LIME): results from a quasi-experimental study BMC public health, 2025
- Implementation of Metformin Therapy to Ease Decline of Kidney Function in Polycystic Kidney Disease (IMPEDE-PKD): study protocol for a phase III, multi-centre, randomized, placebo-controlled trial evaluating the long-term efficacy of metformin in slowing the rate of kidney function decline in patients with autosomal dominant polycystic kidney disease Trials, 2025
- BASTA trial: protocol for a randomised, double-blind, placebo-controlled, crossover trial investigating the effects of atorvastatin on bile acid diarrhoea BMJ open, 2026
- Impact of combined hormonal contraceptives and metformin on metabolic syndrome in women with hyperandrogenic polycystic ovary syndrome and obesity: The COMET-PCOS randomized clinical trial PLoS medicine, 2025
- Metformin for overweight and obese children and adolescents with bipolar spectrum and related mood disorders treated with second-generation antipsychotics: a randomised, pragmatic trial The lancet. Psychiatry, 2025
