Browse studies, page 1214

Page 1214 of 1,286, newest first. Search them all at once, ranked by relevance, in Evidence Hub.

• Effect of Insulin Sensitizers on Glycemic and Lipid Profile in Patients with Polycystic Ovary Syndrome (PCOS) Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki), 2025
• Comparative effects of metformin and lifestyle therapy on bone metabolism markers: A 6-month pilot, open-label randomized-clinical trial Aging clinical and experimental research, 2026
• Metformin attenuates metabolic insulin sensitivity and insulin-stimulated carbohydrate oxidation after high-intensity exercise training in adults at risk for metabolic syndrome Diabetes, obesity & metabolism, 2026
• Tirzepatide Versus Intensified Conventional Care After 2 Years of Treatment in Early Type 2 Diabetes : A Randomized Clinical Trial Annals of internal medicine, 2026
• Long-term safety of oral orforglipron in Japanese participants with type 2 diabetes (ACHIEVE-J): a multicentre, randomised, open-label, parallel-group phase 3 trial The lancet. Diabetes & endocrinology, 2026
• Dulaglutide versus empagliflozin as add-on therapy to metformin and sulfonylurea in type 2 diabetes: a randomized pilot study with exploratory metabolomic and microbiome analyses Frontiers in endocrinology, 2026
• Pharmacokinetic comparison between fixed-dose combination and loose combination of enavogliflozin 0.3 mg and metformin HCl 1000 mg in healthy subjects under fasting and fed conditions Naunyn-Schmiedeberg's archives of pharmacology, 2026
• Effects of 5:2 intermittent fasting meal replacement on body composition and abdominal fat distribution in overweight and obese adults with early type 2 diabetes Clinical nutrition (Edinburgh, Scotland), 2026
• Bioequivalence assessment between two formulations of a film-coated fixed-dose combination of metformin and vildagliptin (850/50mg) in healthy Tunisian subjects under fed conditions Scientific reports, 2026
• Endogenous Glucagon-Like Peptide 1 Enhanced by Vildagliptin Reduces Triglyceride Appearance During Intraduodenal Fat Infusion in Type 2 Diabetes Diabetes, 2026
• Liver Fat Changes in Patients With Type 2 Diabetes by Presence of Genetic Hepatic Steatosis: A Post Hoc Analysis of SURPASS-3 MRI Liver international : official journal of the International Association for the Study of the Liver, 2026
• Exploration of body mass index and circulating metabolic factors as predictors of metformin benefit in the Canadian Cancer Trials Group MA.32 JNCI cancer spectrum, 2026
• Association of cancer antigen 15-3 with distant recurrence in immunohistochemically defined breast cancer subtypes in Canadian Cancer Trials Group MA.32 JNCI cancer spectrum, 2026
• Multi-strain probiotic reduces gastrointestinal side effects in women with elevated HOMA-IR index treated with metformin: a 12-week randomised controlled trial Frontiers in endocrinology, 2026
• Quality of life and patient-reported outcomes after non-surgical management of early-stage endometrial cancer and endometrial hyperplasia with atypia: a long-term follow-up of the feMMe phase II randomized clinical trial International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2026
• HTD1801 in Combination with Metformin for Type 2 Diabetes NEJM evidence, 2026
• Short-Term Combined Treatment With Tirzepatide and Metformin for Overweight/Obese Chinese Women With Polycystic Ovary Syndrome: A Prospective, Open-Label, Randomised Controlled Trial Diabetes, obesity & metabolism, 2026
• The Usefulness of Metformin and Ganwei for Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomized, Placebo-Controlled Trial International journal of molecular sciences, 2026
• Neither Metformin nor Ursodeoxycholic Acid Effectively Treats Postacute Sequelae of COVID-19 : A Randomized Clinical Trial Annals of internal medicine, 2026
• Effects of Premeal Versus Postmeal Metformin Administration on Postmeal Glycemic Control in Individuals With Type 2 Diabetes Mellitus: A Randomized, 8-Week Crossover Study Diabetes, obesity & metabolism, 2026
• Effect of high dose N-acetyl cysteine supplementation on markers of oxidative stress and insulin resistance in non-diabetic patients with metabolic dysfunction associated steatotic liver disease: a randomized controlled trial BMC gastroenterology, 2026
• The role of male foetal sex on maternal and neonatal outcomes in pregnancies complicated by gestational diabetes-secondary analysis of a randomised placebo controlled clinical trial of metformin in gestational diabetes (EMERGE) BMC medicine, 2026
• Orforglipron Added to Titrated Insulin Glargine in Type 2 Diabetes: The ACHIEVE-5 Randomized Clinical Trial JAMA, 2026
• Metformin increases glycolysis and the stress-induced cytokine GDF15 but not FGF21 in humans Frontiers in endocrinology, 2026
• Adjunctive effects of apple cider vinegar on metabolic syndrome and insulin resistance in polycystic ovary syndrome patients receiving metformin: a randomized clinical trial Scientific reports, 2026
• The anti-obesogenic metabolite, Lac-Phe, is elevated by metformin treatment in prostate cancer patients EMBO molecular medicine, 2026
• Effects of combined metformin and cabergoline versus metformin alone on inflammatory markers in Iraqi patients with PCOS and hyperprolactinemia: a randomized clinical trial Journal of medicine and life, 2026
• Metabolic profiling of healthy vs. syndrome-associated obesity and effects of six-month metformin therapy Acta diabetologica, 2026
• Beyond glycemic control: differential effects of empagliflozin and sitagliptin on insulin sensitivity and a shared increase in adropin in type 2 diabetes BMC endocrine disorders, 2026
• Metformin Blunts Vascular Insulin Sensitivity After Exercise Training in Adults at Risk for Metabolic Syndrome The Journal of clinical endocrinology and metabolism, 2026
• Global and Partitioned Polygenic Risk Scores: Associations With Pathophysiology and Incidence of Type 2 Diabetes in People With Prediabetes Diabetes, 2026
• Metformin enhances the pathological response in nondiabetic patients with rectal cancer undergoing neoadjuvant chemoradiotherapy: A randomized controlled trial The Journal of pharmacology and experimental therapeutics, 2026
• Comparative Pharmacokinetics and Bioequivalence Assessment of Metformin/Pioglitazone Tablet in Fasting and Fed Conditions: A Randomized Study in Healthy Chinese Subjects Clinical pharmacology in drug development, 2026
• A Phase II Feasibility Study Combining Pembrolizumab and Metformin in Patients with Metastatic Head and Neck Cancer Clinical cancer research : an official journal of the American Association for Cancer Research, 2026
• The effect of metformin on the pharmacokinetics of rifampicin, isoniazid, and pyrazinamide in adults with tuberculosis Antimicrobial agents and chemotherapy, 2026
• Adjunctive melatonin and sildenafil, enhances antioxidant defense in metformin-treated polycystic ovary syndrome patients: A randomized study Journal of gynecology obstetrics and human reproduction, 2026
• Metformin repurposing in gout: enhancing febuxostat efficacy through anti-inflammatory and metabolic modulation: a randomized controlled double-blind study Inflammopharmacology, 2026
• Multi-strain probiotic enhances metformin tolerance by modulating gut microbiome and bile acid pathways: Insight from multi-omics post-hoc analysis (ProGasMet trial) Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2026
• Effects of UDCA and probiotics on metabolic outcomes in type 2 diabetes patients on metformin: A randomized trial in Bosnia and Herzegovina Technology and health care : official journal of the European Society for Engineering and Medicine, 2026
• Does Metformin Interfere with Cardiorespiratory and Substrate Oxidation Adaptations to Exercise Training in Metabolic Syndrome Patients? A Randomized Placebo-Controlled Trial Biomolecules, 2026
• First-Line Dapagliflozin, Metformin, or Combination Therapy in Type 2 Diabetes: Vascular and Molecular Outcomes of a Randomised Controlled Trial Diabetes, obesity & metabolism, 2026
• Multimodal Therapy With Metformin, Inositol and Dietary Restriction Improves Insulin Resistance and Endocrine Outcomes in Women With Polyendocrine Metabolic Ovarian Syndrome: A Randomized Controlled Trial Clinical endocrinology, 2026
• Determinants of dropout from lifestyle interventions for overweight polycystic ovary syndrome: An exploratory analysis of randomized controlled trial PloS one, 2026
• Efficacy and safety of add-on topiramate vs. metformin on cardiometabolic profile in patients of schizophrenia on atypical antipsychotics with metabolic syndrome: an active-controlled, rater-blinded, parallel-design randomized controlled trial European archives of psychiatry and clinical neuroscience, 2026
• Effects of Pharmacological GIP Infusion on Insulin, Glucagon, and Cardiovascular Responses During Hyperglycemia in Type 2 Diabetes Diabetes, 2026
• Lung function after randomization to metformin, lifestyle intervention or placebo in the Diabetes Prevention Program Outcomes Study (DPPOS) Respiratory medicine, 2026
• Metformin added to lifestyle intervention for physical function in older adults with obesity (DEMFOS trial): a randomised controlled trial The lancet. Healthy longevity, 2026
• Impact of oral contraceptives and metformin on advanced lipid phenotyping in polycystic ovary syndrome European journal of endocrinology, 2026
• Effect of weight change and metformin on fibrinolysis and the von Willebrand factor in obese nondiabetic subjects: the BIGPRO1 Study. Biguanides and the Prevention of the Risk of Obesity Diabetes care, 1998
• Efficacy and safety of acarbose in metformin-treated patients with type 2 diabetes Diabetes care, 1998
• Metformin improves endothelial function in patients with metabolic syndrome Journal of internal medicine, 2005
• Rosiglitazone reduces microalbuminuria and blood pressure independently of glycemia in type 2 diabetes patients with microalbuminuria Journal of hypertension, 2006
• Metformin should be considered in the treatment of gestational diabetes: a prospective randomised study BJOG : an international journal of obstetrics and gynaecology, 2011
• Effect of insulin versus triple oral therapy on the progression of hepatic steatosis in type 2 diabetes Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2012
• Protective effect of metformin on myocardial injury in metabolic syndrome patients following percutaneous coronary intervention Cardiology, 2014
• Midpregnancy Doppler ultrasound of the uterine artery in metformin- versus placebo-treated PCOS women: a randomized trial The Journal of clinical endocrinology and metabolism, 2014
• Metformin therapy increases insulin-stimulated release of D-chiro-inositol-containing inositolphosphoglycan mediator in women with polycystic ovary syndrome The Journal of clinical endocrinology and metabolism, 2004
• Continuing metformin when starting insulin in patients with Type 2 diabetes: a double-blind randomized placebo-controlled trial Diabetic medicine : a journal of the British Diabetic Association, 2005
• Preparation and in vitro/in vivo evaluation of sustained-release metformin hydrochloride pellets European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2006
• Liver dysfunction in paediatric obesity: a randomized, controlled trial of metformin Acta paediatrica (Oslo, Norway : 1992), 2007
• Capabilities of hypoglycemic therapy in women with decompensated type 2 diabetes mellitus Terapevticheskii arkhiv, 2010
• Metformin improves blood lipid pattern in nondiabetic patients with coronary heart disease Journal of internal medicine, 1996
• Pioglitazone metabolic effect in metformin-intolerant obese patients treated with sibutramine Internal medicine (Tokyo, Japan), 2009
• Short-term antidiabetic treatment with insulin or metformin has a similar impact on the components of metabolic syndrome in women with gestational diabetes mellitus requiring antidiabetic agents: results of a prospective, randomised study Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2016
• PREVENT-DM Comparative Effectiveness Trial of Lifestyle Intervention and Metformin American journal of preventive medicine, 2017
• Metformin anticipates peak of lactate during high-intensity interval training but no changes performance or neuromuscular response in amateur swimmers Clinical nutrition ESPEN, 2021
• Metformin in the treatment of HIV lipodystrophy syndrome: A randomized controlled trial JAMA, 2000
• Ovarian function and metabolic factors in women with oligomenorrhea treated with metformin in a randomized double blind placebo-controlled trial The Journal of clinical endocrinology and metabolism, 2002
• Efficacy of glimepiride/metformin combination versus glibenclamide/metformin in patients with uncontrolled type 2 diabetes mellitus Journal of diabetes and its complications, 2009
• The Effect of Metformin in Treatment of Adenomas in Patients with Familial Adenomatous Polyposis Cancer prevention research (Philadelphia, Pa.), 2021
• Effects of initiating insulin and metformin on glycemic control and inflammatory biomarkers among patients with type 2 diabetes: the LANCET randomized trial JAMA, 2009
• Initial therapy with the fixed-dose combination of sitagliptin and metformin results in greater improvement in glycaemic control compared with pioglitazone monotherapy in patients with type 2 diabetes Diabetes, obesity & metabolism, 2012
• Metformin does not reduce markers of cell proliferation in esophageal tissues of patients with Barrett's esophagus Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2015
• PRE-surgical Metformin In Uterine Malignancy (PREMIUM): a Multi-Center, Randomized Double-Blind, Placebo-Controlled Phase III Trial Clinical cancer research : an official journal of the American Association for Cancer Research, 2019
• A randomized, double-blind, placebo-controlled trial of metformin treatment for weight gain associated with initiation of risperidone in children and adolescents Saudi medical journal, 2008
• Hyperreninemia characterizing women with polycystic ovary syndrome improves after metformin therapy Kidney & blood pressure research, 2009
• The effect of metformin on perinatal outcomes in pregnant women with type 2 diabetes differs by baseline insulin requirements American journal of obstetrics and gynecology, 2026
• Metformin to Augment Strength Training Effective Response in Seniors (MASTERS): study protocol for a randomized controlled trial Trials, 2017
• Long-term effects of lifestyle and metformin interventions in DPP on bone density Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2021
• Metformin does not affect postabsorptive hepatic free fatty acid uptake, oxidation or resecretion in humans: A 3-month placebo-controlled clinical trial in patients with type 2 diabetes and healthy controls Diabetes, obesity & metabolism, 2018
• Enzalutamide Plus Metformin Versus Enzalutamide Alone in Metastatic Castration-resistant Prostate Cancer: A Randomized Phase 2 Trial (SAKK 08/14) European urology oncology, 2026
• Childhood follow-up of the GRoW randomized trial: Metformin in addition to dietary and lifestyle advice for pregnant women with overweight or obesity Pediatric obesity, 2023
• Pharmacokinetic Comparison Between a Fixed-Dose Combination of Empagliflozin L-Proline/Metformin and Empagliflozin/Metformin in Healthy Korean Subjects Clinical pharmacology in drug development, 2023
• Protocol for a pilot randomised controlled trial of metformin in pre-diabetes after kidney transplantation: the Transplantation and Diabetes (Transdiab) study BMJ open, 2017
• Assessment of the Drug Interaction Potential of Ertugliflozin With Sitagliptin, Metformin, Glimepiride, or Simvastatin in Healthy Subjects Clinical pharmacology in drug development, 2019
• Metformin alters skeletal muscle transcriptome adaptations to resistance training in older adults Aging, 2020
• Randomized trial comparing the effects of gliclazide, liraglutide, and metformin on diabetes with non-alcoholic fatty liver disease Journal of diabetes, 2017
• Morning exercise and pre-breakfast metformin interact to reduce glycaemia in people with type 2 diabetes: a randomized crossover trial The Journal of physiology, 2024
• Effects of metformin, metformin plus rosiglitazone, and metformin plus lifestyle on insulin sensitivity and β-cell function in TODAY. Diabetes care, 2013
• Health-related quality of life in women with newly diagnosed polycystic ovary syndrome randomized between clomifene citrate plus metformin or clomifene citrate plus placebo Human reproduction (Oxford, England), 2012
• Effects of Metformin Therapy on Coronary Endothelial Dysfunction in Patients With Prediabetes With Stable Angina and Nonobstructive Coronary Artery Stenosis: The CODYCE Multicenter Prospective Study Diabetes care, 2019
• Effect of metformin in pediatric patients with type 2 diabetes: a randomized controlled trial Diabetes care, 2002
• Insulin counter-regulatory factors, fibrinogen and C-reactive protein during olanzapine administration: effects of the antidiabetic metformin International clinical psychopharmacology, 2007
• The effect of pioglitazone as add-on therapy to metformin or sulphonylurea compared to a fixed-dose combination of metformin and glibenclamide on diabetic dyslipidaemia Nutrition, metabolism, and cardiovascular diseases : NMCD, 2008
• Effects of metformin plus gliclazide compared with metformin alone on circulating endothelial progenitor cell in type 2 diabetic patients Endocrine, 2010
• The Primary Glucose-Lowering Effect of Metformin Resides in the Gut, Not the Circulation: Results From Short-term Pharmacokinetic and 12-Week Dose-Ranging Studies Diabetes care, 2016
• Metformin added to intensive insulin therapy improves metabolic control in patients with type 1 diabetes and excess body fat Polish archives of internal medicine, 2018
• Gender-differential effects on blood glucose levels between acarbose and metformin in Chinese patients with newly diagnosed type 2 diabetes: a sub-analysis of the MARCH trial Endocrine journal, 2021
• Physiologically based metformin pharmacokinetics model of mice and scale-up to humans for the estimation of concentrations in various tissues PloS one, 2021
• Combining a diet rich in fermentable carbohydrates with metformin improves glycaemic control and reshapes the gut microbiota in people with prediabetes Nature metabolism, 2025