Browse studies, page 1213

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• Phase II study of metformin for reduction of obesity-associated breast cancer risk: a randomized controlled trial protocol BMC Cancer, 2016
• Dorzagliatin add-on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled phase 3 trial Nature Medicine, 2022
• The AMPK modulator metformin as adjunct to methotrexate in patients with rheumatoid arthritis: A proof-of-concept, randomized, double-blind, placebo-controlled trial International Immunopharmacology, 2021
• Metformin for sepsis-associated AKI: a protocol for the Randomized Clinical Trial of the Safety and FeasibiLity of Metformin as a Treatment for sepsis-associated AKI (LiMiT AKI) BMJ Open, 2024
• Efficacy and safety of metformin plus low-dose temozolomide in patients with recurrent or refractory glioblastoma: a randomized, prospective, multicenter, double-blind, controlled, phase 2 trial (KNOG-1501 study) Discover Oncology, 2023
• Efficacy and Safety of Voglibose Plus Metformin in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial Diabetes & Metabolism Journal, 2018
• Efficacy and safety of ipragliflozin as an add‐on therapy to sitagliptin and metformin in Korean patients with inadequately controlled type 2 diabetes mellitus: A randomized controlled trial Diabetes, obesity and metabolism, 2018
• The effects of vildagliptin compared with metformin on vascular endothelial function and metabolic parameters: a randomized, controlled trial (Sapporo Athero-Incretin Study 3) Cardiovascular Diabetology, 2017
• Efficacy and safety of adding evogliptin versus sitagliptin for metformin‐treated patients with type 2 diabetes: A 24‐week randomized, controlled trial with open label extension Diabetes, obesity and metabolism, 2017
• Increased Metformin Clearance in Overweight and Obese Adolescents: A Pharmacokinetic Substudy of a Randomized Controlled Trial Pediatric Drugs, 2018
• The Effect of Metformin and Cinnamon on Serum Anti-Mullerian Hormone in Women Having PCOS: A Double-Blind, Randomized, Controlled Trial Journal of Human Reproductive Sciences, 2017
• Empagliflozin compared with glimepiride in metformin-treated patients with type 2 diabetes: 208-week data from a masked randomized controlled trial Diabetes, obesity and metabolism, 2018
• A randomized, controlled trial comparing the metformin, oral contraceptive pills and their combination in patients with polycystic ovarian syndrome Journal of Family Medicine and Primary Care, 2018
• Effect of Metformin on Handgrip Strength, Gait Speed, Myostatin Serum Level, and Health-related Quality of Life: A Double Blind Randomized Controlled Trial among Non-diabetic Pre-frail Elderly Patients Acta Medica Indonesiana, 2017
• Repurposing metformin as adjuvant therapy in patients with ulcerative colitis treated with mesalamine: A randomized controlled double-blinded study International Immunopharmacology, 2024
• Improved mobility with metformin in patients with myotonic dystrophy type 1: a randomized controlled trial Brain : a journal of neurology, 2018
• Safety and Efficacy of Exenatide Once Weekly Plus Dapagliflozin Once Daily Versus Exenatide or Dapagliflozin Alone in Patients With Type 2 Diabetes Inadequately Controlled With Metformin Monotherapy: 52-Week Results of the DURATION-8 Randomized Controlled Trial Diabetes Care, 2018
• A 26-Week Randomized Controlled Trial of Semaglutide Once Daily Versus Liraglutide and Placebo in Patients With Type 2 Diabetes Suboptimally Controlled on Diet and Exercise With or Without Metformin Diabetes Care, 2018
• Feasibility and Acceptability of Metformin to Augment Low Milk Supply: A Pilot Randomized Controlled Trial Journal of Human Lactation, 2019
• A 52‐week randomized controlled trial of ipragliflozin or sitagliptin in type 2 diabetes combined with metformin: The N‐ISM study Diabetes, obesity and metabolism, 2020
• N-acetylcysteine and/or ursodeoxycholic acid associated with metformin in NON-alcoholic steatohepatitis: an open-label multicenter randomized controlled trial. Arquivos de Gastroenterologia, 2019
• Comparison of metformin plus myoinositol vs metformin alone in PCOS women undergoing ovulation induction cycles: randomized controlled trial Gynecological Endocrinology, 2019
• A randomized controlled trial on the efficacy, safety, and pharmacokinetics of metformin in severe traumatic brain injury Journal of Neurology, 2019
• Outcomes and safety of concomitant topiramate or metformin for antipsychotics-induced obesity: a randomized-controlled trial Annals of General Psychiatry, 2020
• Comparing the individual effects of metformin and rosiglitazone and their combination in obese women with polycystic ovary syndrome: a randomized controlled trial Fertility and Sterility, 2019
• Short-term effect of polyethylene glycol loxenatide on weight loss in overweight or obese patients with type 2 diabetes: An open-label, parallel-arm, randomized, metformin-controlled trial Frontiers in Endocrinology, 2023
• A metformin add-on clinical study in multiple sclerosis to evaluate brain remyelination and neurodegeneration (MACSiMiSE-BRAIN): study protocol for a multi-center randomized placebo controlled clinical trial Frontiers in Immunology, 2024
• Metformin and insulin treatment of gestational diabetes: effects on inflammatory markers and IGF-binding protein-1 – secondary analysis of a randomized controlled trial BMC Pregnancy and Childbirth, 2020
• Evaluation of the gut microbiota after metformin intervention in children with obesity: A metagenomic study of a randomized controlled trial Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020
• Effects of Short Term Metformin Treatment on Brown Adipose Tissue Activity and Plasma Irisin Levels in Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial Hormone and Metabolic Research, 2020
• A randomized controlled trial of metformin on left ventricular hypertrophy in patients with coronary artery disease without diabetes: the MET-REMODEL trial European Heart Journal, 2019
• Therapeutic Effect of Curcumin in Women with Polycystic Ovary Syndrome Receiving Metformin: A Randomized Controlled Trial Advances in Experimental Medicine and Biology, 2021
• Ipragliflozin Additively Ameliorates Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Controlled with Metformin and Pioglitazone: A 24-Week Randomized Controlled Trial Journal of Clinical Medicine, 2020
• Antecedent Metabolic Health and Metformin (ANTHEM) Aging study: Rationale and study design for a randomized controlled trial medRxiv, 2021
• A randomized controlled trial of metformin in women with components of metabolic syndrome: Intervention feasibility and effects on adiposity and breast density Breast Cancer Research and Treatment, 2021
• Effect of acupuncture and metformin on insulin sensitivity in women with polycystic ovary syndrome and insulin resistance: a three-armed randomized controlled trial Human Reproduction, 2021
• Metformin for Knee Osteoarthritis in Patients With Overweight or Obesity: A Randomized Clinical Trial Journal of the American Medical Association (JAMA), 2025
• Pioglitazone as Add-on Therapy in Patients with Type 2 Diabetes Mellitus Inadequately Controlled with Dapagliflozin and Metformin: Double-Blind, Randomized, Placebo-Controlled Trial Diabetes & Metabolism Journal, 2024
• A 96‐week, double‐blind, randomized controlled trial comparing bexagliflozin to glimepiride as an adjunct to metformin for the treatment of type 2 diabetes in adults Diabetes, obesity and metabolism, 2022
• Repurposing metformin as anticancer drug: Randomized controlled trial in advanced prostate cancer (MANSMED) Urologic oncology, 2021
• The impact of metformin use on the outcomes of locally advanced breast cancer patients receiving neoadjuvant chemotherapy: an open-labelled randomized controlled trial Scientific Reports, 2022
• Metformin and N-terminal pro B-type natriuretic peptide in type 2 diabetes patients, a post-hoc analysis of a randomized controlled trial PLoS ONE, 2021
• Metformin, testosterone, or both in men with obesity and low testosterone: A double-blind, parallel-group, randomized controlled trial Metabolism: Clinical and Experimental, 2022
• Canagliflozin combined with metformin versus metformin monotherapy for endocrine and metabolic profiles in overweight and obese women with polycystic ovary syndrome: A single-center, open-labeled prospective randomized controlled trial Frontiers in Endocrinology, 2022
• A randomized controlled trial comparing myoinositol with metformin versus metformin monotherapy in polycystic ovary syndrome Clinical Endocrinology, 2023
• Efficacy of metformin in prevention of paclitaxel-induced peripheral neuropathy in breast cancer patients: a randomized controlled trial Frontiers in Pharmacology, 2023
• Effect of Metformin on Oxidative Stress and Left Ventricular Geometry in Nondiabetic Heart Failure Patients: A Randomized Controlled Trial Metabolic Syndrome and Related Disorders, 2023
• Efficacy and Safety of Dulaglutide 3.0 mg and 4.5 mg Versus Dulaglutide 1.5 mg in Metformin-Treated Patients With Type 2 Diabetes in a Randomized Controlled Trial (AWARD-11) Diabetes Care, 2021
• Effects of metformin and donepezil on the prevention of doxorubicin-induced cardiotoxicity in breast cancer: a randomized controlled trial Scientific Reports, 2023
• Efficacy of WeChat-Based Digital Intervention Versus Metformin in Women With Polycystic Ovary Syndrome: Randomized Controlled Trial Journal of Medical Internet Research, 2024
• Metformin Improves Sarcopenia-Related Quality of Life in Geriatric Adults: A Randomized Controlled Trial Archives of Medical Research, 2024
• Neonatal outcomes in case of euglycemic control in gestational diabetes using insulin versus metformin. Randomized controlled trial 2021
• Metformin with neoadjuvant chemotherapy in localized triple-negative and Her2neu-positive breast cancer: A prospective phase 2 open-label randomized controlled trial (McBETH) Cancer, 2025
• Evaluation of Horizontal Ridge Augmentation Using 1% Metformin Gel and PRF in Split Crest Technique: A Randomized Controlled Clinical Trial The journal of contemporary dental practice, 2025
• Effect of a Medication Adherence Education Intervention on Clinical Outcomes in Adults with Type 2 Diabetes Mellitus: A Randomized Controlled Trial Study Endocrine, metabolic & immune disorders drug targets, 2026
• Addition of sitagliptin to ongoing metformin improved metabolic profile and pancreatic function via normalizing inflammatory cytokines' levels in patients with type 2 diabetes, a randomized double-blinded clinical trial Expert review of endocrinology & metabolism, 2025
• Orforglipron compared with dapagliflozin in adults with type 2 diabetes and inadequate glycaemic control with metformin (ACHIEVE-2): a multicentre, randomised, non-inferiority, open-label, phase 3 trial Lancet (London, England), 2026
• Medication count, including statin or metformin use, is not associated with influenza vaccine responses in older adults Vaccine, 2025
• Can maternal metformin protect the developing fetal brain? American journal of obstetrics and gynecology, 2026
• Impact of Albuminuria-Lowering Treatments on Cardiovascular Predictive Ceramides in Diabetes: Post Hoc Analysis of the ROTATE Trials Diabetes, obesity & metabolism, 2026
• Community health worker-led versus facility-based type 2 diabetes care in rural Lesotho: a cluster-randomized trial within the ComBaCaL cohort study BMC medicine, 2026
• Efficacy and tolerability of metformin as an adjuvant therapy in patients with relapse-remitting multiple sclerosis receiving interferon Beta 1a: A randomized pilot trial Journal of neuroimmunology, 2026
• The effects of chiglitazar and metformin on insulin resistance in women with a normal BMI and polycystic ovary syndrome: a randomized controlled study BMC endocrine disorders, 2025
• Effect of probiotics derivatives (postbiotics and metabiotics) on glycemic control in individuals with type 2 diabetes: a randomized clinical trial (DELI_Diab study) Frontiers in endocrinology, 2026
• Effects of insulin and exenatide therapy on glycemic control and β-cell function in patients newly diagnosed with type 2 diabetes and severe hyperglycemia Journal of the Chinese Medical Association : JCMA, 2026
• Combination metformin and liraglutide in PCOS: clinical efficacy in women and preclinical insights from gut microbiome modulation in rats Frontiers in endocrinology, 2025
• Metformin Alters Exercise Training Induced Blood Pressure and Aortic Waveform Adaptations in Adults at Risk for Metabolic Syndrome Journal of clinical hypertension (Greenwich, Conn.), 2026
• A randomized controlled trial of real-time continuous glucose monitoring (RT-CGM) for self-management of gestational diabetes American journal of obstetrics & gynecology MFM, 2026
• Sitagliptin, Metformin and Glimepiride Fixed-Dose Combination Compared to Co-Administration of Metformin and High-Dose Glimepiride in Indian Patients With Type 2 Diabetes: A Randomised, Double-Blind, Double-Dummy, Phase 3 Clinical Study Diabetes, obesity & metabolism, 2026
• Impact of iGlarLixi on Glycaemic Control Depth and Variability in Asian Pacific People With Type 2 Diabetes: A Post Hoc Analysis of LixiLan-O-AP and LixiLan-L-CN Diabetes, obesity & metabolism, 2026
• The Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID : An Adaptive Randomized Trial Annals of internal medicine, 2026
• Association between Neonatal Hypoglycemia and 30-Day Breastfeeding Outcomes among Gravidas with Type 2 Diabetes American journal of perinatology, 2026
• Comparison of the Continuous Glucose Monitoring Profiles of Four Glucose-Lowering Medications in the GRADE Randomized Trial Diabetes care, 2026
• Effect of metformin on insulin resistance in adults with type 1 diabetes: a 26-week randomized double-blind clinical trial Nature communications, 2025
• The effects of Bifidobacterium animalis subsp. lactis BLa80 on glycemic control and gut microbiota in patients with T2DM: a randomized, double-blind, placebo-controlled trial Journal of diabetes and its complications, 2025
• HRS-7535 for Type 2 Diabetes Inadequately Controlled With Metformin: A Randomized Clinical Trial JAMA network open, 2026
• Effects of short-term tofogliflozin treatment on the insulin secretory capacity of people with type 2 diabetes: A randomized controlled trial, the TOP-ELM study Journal of diabetes investigation, 2026
• An intervention study of the general practice management of older adults with cardiovascular metabolic comorbidities PloS one, 2026
• Efficacy Of Combined Nutritional And Pharmacological Interventions In PCOS: A Six Month Randomized Controlled Trial Naunyn-Schmiedeberg's archives of pharmacology, 2026
• Efficacy and safety of once-daily oral zenagamtide, a novel unimolecular GLP-1 and amylin receptor agonist, in adults with type 2 diabetes: a multicentre, randomised, parallel, double-blind, placebo-controlled, dose-finding, phase 2 trial Lancet (London, England), 2026
• Impact of a pharmacist adherence intervention on medication beliefs and drug-related problems in coronary patients - a process evaluation of the MIMeRiC trial BMC health services research, 2026
• Efficacy and safety of once-weekly subcutaneous zenagamtide, a novel unimolecular GLP-1 and amylin receptor agonist, in type 2 diabetes: a multicentre, randomised, parallel, double-blind, placebo-controlled, dose-finding, phase 2 trial Lancet (London, England), 2026
• Adjuvant potential of metformin with standard anti-seizure medications in persons with active epilepsy: a randomised controlled trial Naunyn-Schmiedeberg's archives of pharmacology, 2026
• Efficacy and safety of adding a fourth oral antidiabetic drug versus metformin dose escalation in patients with type 2 diabetes inadequately controlled on triple oral combination therapy (EFFORT): A 24-week, randomized, open-label, multicenter trial Diabetes, obesity & metabolism, 2026
• The effect of oral magnesium supplementation on glycemic control and metabolic parameters in type 2 diabetes mellitus: a double-blind randomized controlled trial Frontiers in endocrinology, 2026
• Oral polychemotherapy to induce remission in newly diagnosed type 2 diabetes: results from a randomized controlled trial Journal of endocrinological investigation, 2026
• Effects of metformin and Denosumab on bone and glucose metabolism in postmenopausal women with OP and OA. The Journal of endocrinology, 2025
• Sex differences in cardiac structure and function following ST-segment elevation myocardial infarction Scientific reports, 2026
• The Impact of Different Oral Antidiabetic Drugs on Insulin Pump Intensive Therapy in Type 2 Diabetes Patients: A Clinical Study Journal of diabetes research, 2026
• Multiparameter MRI assessment of metformin and exercise effects on skeletal muscle in prediabetes: a randomized controlled trial European radiology experimental, 2025
• Efficacy and Safety of Glimepiride, Voglibose, and Metformin ER in Type 2 Diabetes: A Randomized, Active-Controlled Study Journal of diabetes, 2026
• Circulating Profiles of the Bile Acid Metabolomics in Patients With Polycystic Ovary Syndrome Treated With Metformin or Canagliflozin Pharmacotherapy, 2026
• Ketone supplementation dose-dependently lowers postprandial blood glucose, lipid and ghrelin levels in individuals with type 2 diabetes: a randomised crossover study Diabetologia, 2026
• Empagliflozin as an Alternative to Metformin for Antipsychotic-Related Weight Gain: Double-Blind Randomized Controlled Trial Human psychopharmacology, 2026
• Effects of Ziziphus jujuba, metformin, and myoinositol on pregnancy rates and metabolic parameters in infertile women with PCOS: a randomized controlled trial Journal of ovarian research, 2026
• Lifestyle and Metformin Interventions and Risk of Multimorbidity in Adults With Prediabetes JAMA, 2026
• The effectiveness of care coordination on medication adherence among high-need, high-cost commercially insured beneficiaries: A randomized controlled trial Journal of managed care & specialty pharmacy, 2026
• Efficacy and safety of anagliptin added to metformin and empagliflozin 25 mg in patients with type 2 diabetes: a 24-week randomized, double-blind, placebo-controlled phase 3 trial with 28-week open-label extension Diabetes research and clinical practice, 2026
• Efficacy and safety of combining olorigliflozin with metformin in patients with type 2 diabetes mellitus inadequately controlled on metformin monotherapy Zhonghua yi xue za zhi, 2026
• Metformin Reduces the Incidence of Shoulder Stiffness After Arthroscopic Rotator Cuff Repair: A Randomized, Double-Blinded, Placebo-Controlled Trial The American journal of sports medicine, 2025