Browse studies, page 1212

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• Efficacy and Safety of Fixed-Dose Combinations of Sitagliptin and Empagliflozin as Add-On to Metformin in Korean Patients With Type 2 Diabetes: A Randomised, Double-Blind, Multi-Centre, Placebo-Controlled, Phase III Trial Diabetes, obesity & metabolism, 2026
• Prediction of time to insulin initiation in gestational diabetes mellitus: a secondary analysis of the EMERGE trial Diabetes research and clinical practice, 2026
• Efficacy and safety of Efsubaglutide Alfa in "overrun" patients in the SUPER2 trial: A post-hoc analysis for comprehensive evaluation Diabetes, obesity & metabolism, 2025
• Insulin Sensitivity and Beta Cell Function With Macupatide Alone or With Dulaglutide in Type 2 Diabetes: A Phase 1b, Randomised Controlled Trial Diabetes, obesity & metabolism, 2026
• Safety and feasibility trial protocol of metformin in infants after perinatal brain injury BMJ paediatrics open, 2025
• Elecoglipron, an oral small molecule GLP-1 receptor agonist in adults with type 2 diabetes (SOLSTICE): a multicentre, phase 2b, randomised, placebo-controlled trial Lancet (London, England), 2026
• Hydroxychloroquine as an adjunct therapy in the management of type 2 diabetes in pregnancy: study protocol for a randomised controlled trial BMJ open, 2026
• Cagrilintide-semaglutide (CagriSema) as an add-on to basal insulin in adults with type 2 diabetes (REIMAGINE 3): a randomised, double-blind, placebo-controlled, multicentre, phase 3 study Lancet (London, England), 2026
• Effectiveness of Metformin Prolonged-Release Formulation on Achievement of Optimal Glycemic Control in Gestational Diabetes Mellitus: Protocol for a Pilot, Randomized, Double-Blind, Clinical Trial JMIR research protocols, 2025
• A phase II study of nivolumab plus metformin in pre-treated metastatic renal cell carcinoma patients: NivoMet TWINS-GU002 Study Tumori, 2025
• Cagrilintide-semaglutide (CagriSema) versus semaglutide or cagrilintide in people with type 2 diabetes (REIMAGINE 2): a double-blind, randomised, controlled, phase 3 study The lancet. Diabetes & endocrinology, 2026
• Metformin Impact on Maternal and Infant Cardiometabolic Health (MIMICH), an open-label randomised controlled trial, and Metformin Impact on Maternal and Cardiometabolic Health After Pregnancy (MIMICH II) Trials, 2025
• Metformin to Improve Walking Performance in Lower Extremity Peripheral Artery Disease: The PERMET Randomized Clinical Trial JAMA, 2026
• Randomized controlled trial of effects of metformin in NAFLD patients with newly diagnosed type 2 diabetes treated with an intensive lifestyle: a study protocol Trials, 2025
• Study protocol of a multicenter, randomized, non-inferiority, open-label study investigating the efficacy of a fixed-dose combination regimen of dapagliflozin/metformin versus co-administered dual therapy based on glycemic control, satisfaction and adherence in patients with newly diagnosed type 2 diabetes mellitus Frontiers in endocrinology, 2025
• The Cambridge Centre for Myelin Repair trial Two (CCMR Two): a trial protocol for a phase 2a, randomised, double-blind, placebo-controlled clinical trial of the ability of the combination of metformin and clemastine to promote remyelination in people with relapsing-remitting multiple sclerosis already on disease-modifying therapy Trials, 2025
• The LIFE-MET trial: effect of insulin sensitization on pubertal progression following lifestyle intervention and/or treatment with metformin in girls with early puberty and overweight: study protocol for a randomized, placebo-controlled trial Trials, 2025
• Letrozole, abemaciclib and metformin in endometrial cancer: a non-randomized phase 2 trial Nature communications, 2025
• Metformin for the treatment of unruptured vertebrobasilar dissecting aneurysm (METTLE): study protocol for a double-blinded randomised controlled trial Trials, 2025
• Is metformin therapy in conjunction with lifestyle modifications more effective than lifestyle modifications alone in lowering the risk of gestational diabetes mellitus in pregnant women with metabolic dysfunction-associated steatotic liver disease (MASLD)? A protocol for parallel-arm superiority randomised controlled trial in tertiary care centres, Puducherry, South India BMJ open, 2025
• Mazdutide versus Semaglutide for the treatment of type 2 diabetes and obesity: Rationale, design and baseline data of DREAMS-3 phase 3 trial Contemporary clinical trials, 2026
• DIVINE-pilot trial: a phase 2 multicentre, randomised pilot trial of pharmacotherapy and physical activity monitoring conducted in women with recent gestational diabetes and increased risk of type 2 diabetes recruited from tertiary referral hospitals in Australia BMJ open, 2025
• Effects of combined oral contraceptives and metformin on paraoxonase 1 lactonase activity and status in patients with polycystic ovary syndrome and insulin resistance Frontiers in endocrinology, 2025
• Adding empagliflozin to ongoing metformin improves metabolic profile, tg-g and fib-4 indexes and liver function tests in type 2 diabetic patients with NAFLDS, a clinical trial Expert review of endocrinology & metabolism, 2025
• The 5:2 Diet Reduces Risk Factors for Cardiovascular Disease in Subjects with and Without Type 2 Diabetes-A Non-Randomized Controlled Trial International journal of molecular sciences, 2026
• Metformin inhibits proliferation of residing fibroadipogenic progenitor cells from failing human hearts ESC heart failure, 2026
• The role of short-term metformin in regulating zinc and adipose tissue-derived biomarkers in children with obesity and insulin resistance BMC endocrine disorders, 2026
• Study protocol: role of the blood-brain barrier in stress resilience: investigating new pathways towards Pharmacological augmentation of stress resilience (a PHASR-PP project study) BMC psychology, 2026
• Polyethylene Glycol Loxenatide Selectively Reduces Adiposity While Preserving Lean Body Mass in Type 2 Diabetes: A 12-Week Clinical Study Diabetes, metabolic syndrome and obesity : targets and therapy, 2026
• Optimising metformin use in polycystic ovary syndrome (MET-PCOS): study protocol for a double-blind randomised controlled trial BMJ open, 2026
• EMERGE Mothers and Kids: a longitudinal cohort study of mothers and children enrolled in the randomized placebo-controlled trial of metformin in women with GDM (EMERGE): study protocol Trials, 2026
• Efficacy and Safety of Topical Metformin vs Kligman Formula in the Treatment of Melasma: A Split-Face Study Journal of drugs in dermatology : JDD, 2026
• REPROGRAM: REsilience PROmotion with GeRoprotectors: AssessMent of biological effect: Rationale and protocol for a trial of biological effect PloS one, 2026
• Efficacy and safety of SarogLItazar as an add-on medication to Metformin and lifestyle intervention in women with PolyCystic Ovary Syndrome (SLIM-PCOS trial): study protocol for a randomized, open-label, parallel group clinical trial Trials, 2026
• Efsubaglutide alfa added to metformin improves glycaemia with β-cell functional responses in type 2 diabetes: a randomised, double-blind, placebo-controlled, two-stage adaptive phase 2b/3 trial (SUPER 2) Nature communications, 2026
• Association between preoperative metformin exposure and postoperative nausea and vomiting in patients undergoing general anaesthesia: a protocol for a prospective observational cohort study in a Chinese tertiary hospital BMJ open, 2026
• Geroprotective effects of diet and exercise plus metformin in frail older veterans with obesity: The DEMFOS randomized trial protocol Contemporary clinical trials, 2026
• Metformin and Weight Changes in Non-diabetic Older People With HIV (METFORAGING): A Double-Blind, Randomized, Placebo-Controlled, Pilot Trial Open forum infectious diseases, 2026
• Effect of fish oil as an adjunct therapy to metformin on vascular and cardiac health in women with polyendocrine metabolic ovarian syndrome: protocol for a randomised, placebo-controlled clinical trial BMJ open, 2026
• Continuation of metformin reduces early pregnancy loss in obese Pakistani women with polycystic ovarian syndrome Gynecologic and obstetric investigation, 2010
• The Effect of Metformin on Hypothalamic-Pituitary-Thyroid Axis Activity in Women with Interferon-Induced Hypothyroidism: A Pilot Study Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2016
• The administration of metformin during pregnancy reduces polycystic ovary syndrome related gestational complications European journal of obstetrics, gynecology, and reproductive biology, 2011
• Sensitization to insulin induces ovulation in nonobese adolescents with anovulatory hyperandrogenism The Journal of clinical endocrinology and metabolism, 2001
• Metformin in the treatment of non-alcoholic steatohepatitis: a pilot open label trial Alimentary pharmacology & therapeutics, 2004
• Rapid determination of metformin in human plasma using ion-pair HPLC. Journal of pharmaceutical and biomedical analysis, 2003
• Pharmacokinetics of metformin in patients with chronic kidney disease stage 4 and metformin-naïve type 2 diabetes Pharmacology research & perspectives, 2018
• Metformin Downregulates the STAT Pathway and Reduces Bone Marrow Fibrosis in Primary Myelofibrosis Patients: Final Results of the Phase II FIBROMET Trial Hematological oncology, 2026
• Changes in the gut microbiome influence the hypoglycemic effect of metformin through the altered metabolism of branched-chain and nonessential amino acids Diabetes research and clinical practice, 2021
• Metformin for obese, insulin-treated diabetic patients: improvement in glycaemic control and reduction of metabolic risk factors European journal of clinical pharmacology, 1993
• Metformin for patients with advanced stage ovarian cancer: A randomized phase II placebo-controlled trial Gynecologic oncology, 2025
• Prospective, randomized trial of metformin and vitamins for the reduction of plasma homocysteine in insulin-resistant polycystic ovary syndrome Fertility and sterility, 2007
• Clinical and endocrinological effects of 6 months of metformin treatment in young hyperinsulinemic patients affected by polycystic ovary syndrome Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2002
• Comparison of pioglitazone and metformin efficacy using homeostasis model assessment Diabetic medicine : a journal of the British Diabetic Association, 2004
• Oral antidiabetic drugs: effect of food on absorption of pioglitazone and metformin from a fixed-dose combination tablet Journal of clinical pharmacology, 2007
• Relation between augmentation index and adiponectin during one-year metformin treatment for nonalcoholic steatohepatosis: effects beyond glucose lowering? Cardiovascular diabetology, 2012
• The Effect of Metformin on Short-Chain Fatty Acid Levels in Patients with Chronic Heart Failure, Prediabetes, and Sarcopenia Kardiologiia, 2025
• MARCH2: comparative assessment of therapeutic effects of acarbose and metformin in newly diagnosed type 2 diabetes patients PloS one, 2014
• Sustained Maternal Hyperandrogenism During PCOS Pregnancy Reduced by Metformin in Non-obese Women Carrying a Male Fetus The Journal of clinical endocrinology and metabolism, 2020
• Growth, body composition and metabolic profile of 8-year-old children exposed to metformin in utero Scandinavian journal of clinical and laboratory investigation, 2012
• Disuse-induced muscle fibrosis, cellular senescence, and senescence-associated secretory phenotype in older adults are alleviated during re-ambulation with metformin pre-treatment Aging cell, 2023
• Improvements in glycemic control in type 2 diabetes patients switched from sulfonylurea coadministered with metformin to glyburide-metformin tablets Journal of managed care pharmacy : JMCP, 2003
• The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes with metformin alone Diabetes care, 2009
• Saxagliptin and metformin XR combination therapy provides glycemic control over 24 hours in patients with T2DM inadequately controlled with metformin Current medical research and opinion, 2010
• Comparison of metformin and N-acetyl cysteine, as an adjuvant to clomiphene citrate, in clomiphene-resistant women with polycystic ovary syndrome Journal of gynecology obstetrics and human reproduction, 2017
• Metformin adjunctive therapy with insulin improves glycemic control in patients with type 1 diabetes mellitus: a pilot study Journal of pediatric endocrinology & metabolism : JPEM, 2002
• Metformin versus sibutramine in the treatment of hyperinsulinemia in chronically anovulating women Bratislavske lekarske listy, 2004
• Effect of metformin on methylglyoxal metabolism in patients with type 2 diabetes Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2014
• Increased insulin-like growth factor-I levels in women with polycystic ovary syndrome, and beneficial effects of metformin therapy Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2004
• Metformin decreases plasma resistin concentrations in pediatric patients with impaired glucose tolerance: a placebo-controlled randomized clinical trial Metabolism: clinical and experimental, 2012
• Long-term safety and efficacy of empagliflozin, sitagliptin, and metformin: an active-controlled, parallel-group, randomized, 78-week open-label extension study in patients with type 2 diabetes Diabetes care, 2013
• In PCOS patients the addition of low-dose spironolactone induces a more marked reduction of clinical and biochemical hyperandrogenism than metformin alone Nutrition, metabolism, and cardiovascular diseases : NMCD, 2014
• Effect of Diane-35, alone or in combination with orlistat or metformin in Chinese polycystic ovary syndrome patients Archives of gynecology and obstetrics, 2018
• Effects of pioglitazone in combination with metformin or a sulfonylurea compared to a fixed-dose combination of metformin and glibenclamide in patients with type 2 diabetes Diabetes technology & therapeutics, 2007
• Metformin maintains intrahepatic triglyceride content through increased hepatic de novo lipogenesis European journal of endocrinology, 2022
• Metformin-Associated Lactic Acidosis Undergoing Renal Replacement Therapy in Intensive Care Units: A Five-Million Population-Based Study in the North-West of Italy Blood purification, 2017
• Long-term treatment with metformin in obese, insulin-resistant adolescents: results of a randomized double-blinded placebo-controlled trial Nutrition & Diabetes, 2016
• Effect of once‐weekly semaglutide versus thrice‐daily insulin aspart, both as add‐on to metformin and optimized insulin glargine treatment in participants with type 2 diabetes (SUSTAIN 11): A randomized, open‐label, multinational, phase 3b trial Diabetes, obesity and metabolism, 2022
• The ASAMET trial: a randomized, phase II, double-blind, placebo-controlled, multicenter, 2 × 2 factorial biomarker study of tertiary prevention with low-dose aspirin and metformin in stage I-III colorectal cancer patients BMC Cancer, 2018
• Efficacy and Safety of Mazdutide in Chinese Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial Diabetes Care, 2023
• Dapagliflozin effect on endothelial dysfunction in diabetic patients with atherosclerotic disease: a randomized active-controlled trial Cardiovascular Diabetology, 2021
• Long-term treatment with metformin in type 2 diabetes and methylmalonic acid: Post hoc analysis of a randomized controlled 4.3year trial Journal of diabetes and its complications, 2018
• Efficacy and safety benefits of iGlarLixi versus insulin glargine 100 U/mL or lixisenatide in Asian Pacific people with suboptimally controlled type 2 diabetes on oral agents: The LixiLan‐O‐AP randomized controlled trial Diabetes, obesity and metabolism, 2022
• Efficacy and safety of polyethylene glycol loxenatide as add‐on to metformin in patients with type 2 diabetes: A multicentre, randomized, double‐blind, placebo‐controlled, phase 3b trial Diabetes, obesity and metabolism, 2020
• Liraglutide and sitagliptin have no effect on intestinal microbiota composition: A 12-week randomized placebo-controlled trial in adults with type 2 diabetes Diabetes & Metabolism, 2021
• Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19 New England Journal of Medicine, 2022
• Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial Nutrients, 2021
• Effect of Metformin vs Placebo on Invasive Disease-Free Survival in Patients With Breast Cancer: The MA.32 Randomized Clinical Trial Journal of the American Medical Association (JAMA), 2022
• Clomiphene citrate, metformin or a combination of both as the first line ovulation induction drug for Asian Indian women with polycystic ovarian syndrome: A randomized controlled trial Journal of Human Reproductive Sciences, 2015
• Effect of Calcium and Vitamin D Supplements as an Adjuvant Therapy to Metformin on Menstrual Cycle Abnormalities, Hormonal Profile, and IGF-1 System in Polycystic Ovary Syndrome Patients: A Randomized, Placebo-Controlled Clinical Trial Advances in Pharmacological Sciences, 2019
• The effect of metformin versus placebo in combination with insulin analogues on bone mineral density and trabecular bone score in patients with type 2 diabetes mellitus: a randomized placebo-controlled trial Osteoporosis International, 2018
• The effect of vitamin C and/or E supplementations on type 2 diabetic adult males under metformin treatment: A single-blinded randomized controlled clinical trial Diabetes & metabolic syndrome, 2018
• Impact of metformin on anti-Müllerian hormone in women with polycystic ovary syndrome: a secondary analysis of a randomized controlled trial Acta Obstetricia et Gynecologica Scandinavica, 2015
• Metformin in gestational diabetes mellitus: A double-blind placebo-controlled randomized trial International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2021
• A randomized controlled trial of clomifene citrate, metformin, and pioglitazone versus letrozole, metformin, and pioglitazone for clomifene-citrate-resistant polycystic ovary syndrome International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2016
• Early Metformin in Gestational Diabetes: A Randomized Clinical Trial Journal of the American Medical Association (JAMA), 2023
• Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double‐blind, placebo‐controlled, multicenter trial: The MASTERS trial Aging Cell, 2019
• Antioxidant effects of astaxanthin and metformin combined therapy in type 2 diabetes mellitus patients: a randomized double-blind controlled clinical trial Research in Pharmaceutical Sciences, 2022
• Effect of Metformin For Decreasing Proliferative Marker in Women with Endometrial Cancer: A Randomized Double-Blind Placebo-Controlled Trial Asian Pacific Journal of Cancer Prevention, 2020
• Treating Insulin Resistance With Metformin as a Strategy to Improve Clinical Outcomes in Treatment-Resistant Bipolar Depression (the TRIO-BD Study): A Randomized, Quadruple-Masked, Placebo-Controlled Clinical Trial Journal of Clinical Psychiatry, 2022
• Metformin in women with type 2 diabetes in pregnancy (MiTy): a multi-center randomized controlled trial BMC Pregnancy and Childbirth, 2016